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51 results

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Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration.
Merta H, Gov K, Isogai T, Paul B, Sannigrahi A, Radhakrishnan A, Danuser G, Henne WM. Merta H, et al. Cell Rep. 2025 Apr 22;44(4):115502. doi: 10.1016/j.celrep.2025.115502. Epub 2025 Apr 3. Cell Rep. 2025. PMID: 40184252 Free PMC article.
We uncover an ER-enriched actin-binding protein, calmin/CLMN, and define it as an ER-actin tether that localizes to focal adhesions adjacent to ER tubules. Mechanistically, we find that CLMN depletion perturbs adhesion disassembly, actin dynamics, and cell movement. …
We uncover an ER-enriched actin-binding protein, calmin/CLMN, and define it as an ER-actin tether that localizes to focal adhesions a …
Diagnostic Yield and Novel Candidate Genes by Exome Sequencing in 152 Consanguineous Families With Neurodevelopmental Disorders.
Reuter MS, Tawamie H, Buchert R, Hosny Gebril O, Froukh T, Thiel C, Uebe S, Ekici AB, Krumbiegel M, Zweier C, Hoyer J, Eberlein K, Bauer J, Scheller U, Strom TM, Hoffjan S, Abdelraouf ER, Meguid NA, Abboud A, Al Khateeb MA, Fakher M, Hamdan S, Ismael A, Muhammad S, Abdallah E, Sticht H, Wieczorek D, Reis A, Abou Jamra R. Reuter MS, et al. JAMA Psychiatry. 2017 Mar 1;74(3):293-299. doi: 10.1001/jamapsychiatry.2016.3798. JAMA Psychiatry. 2017. PMID: 28097321
Of these, 14 were homozygous and truncating in GRM7, STX1A, CCAR2, EEF1D, GALNT2, SLC44A1, LRRIQ3, AMZ2, CLMN, SEC23IP, INIP, NARG2, FAM234B, and TRAP1. The diagnostic yield was higher in individuals with severe ID (35 of 77 [45.5%]), in multiplex families (42 of 107 [39.3 …
Of these, 14 were homozygous and truncating in GRM7, STX1A, CCAR2, EEF1D, GALNT2, SLC44A1, LRRIQ3, AMZ2, CLMN, SEC23IP, INIP, NARG2, …
Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration.
Merta H, Isogai T, Paul B, Danuser G, Henne WM. Merta H, et al. bioRxiv [Preprint]. 2024 Jan 25:2024.01.24.577043. doi: 10.1101/2024.01.24.577043. bioRxiv. 2024. Update in: Cell Rep. 2025 Apr 22;44(4):115502. doi: 10.1016/j.celrep.2025.115502. PMID: 38328045 Free PMC article. Updated. Preprint.
CLMN depletion perturbs focal adhesion disassembly, actin dynamics, and cell movement. Mechanistically, CLMN-depleted cells also exhibit defects in calcium signaling near ER-actin interfaces, suggesting CLMN promotes calcium signaling near adhesions to facili …
CLMN depletion perturbs focal adhesion disassembly, actin dynamics, and cell movement. Mechanistically, CLMN-depleted cells al …
Potential Significance and Clinical Value Explorations of Calmin (CLMN) in Breast Invasive Carcinoma.
Wu Y, Liu CP, Xiang C, Xiang KF. Wu Y, et al. Int J Gen Med. 2021 Sep 10;14:5549-5561. doi: 10.2147/IJGM.S326960. eCollection 2021. Int J Gen Med. 2021. PMID: 34531680 Free PMC article.
OBJECTIVE: Function of calmin (CLMN) was rarely reported in human diseases, especially in tumor. Present study initially assessed the significance of CLMN in breast invasive carcinoma (BRCA). METHODS: Expressions of CLMN containing mRNA and protein in BRCA wa …
OBJECTIVE: Function of calmin (CLMN) was rarely reported in human diseases, especially in tumor. Present study initially assessed the …
Exploration of the active components and pharmacological mechanism of Compound Longmaining for the treatment of myocardial infarction.
Li J, Wang X, Bu D, Zou J, Xun S, Wang Y, Jia Y, Yu S, Wang W, Zheng J, Hou J, Zhang X, Wang C. Li J, et al. Front Biosci (Landmark Ed). 2021 Oct 30;26(10):813-827. doi: 10.52586/4990. Front Biosci (Landmark Ed). 2021. PMID: 34719208 Free article.
An immunohistochemical analysis showed that the TNF-alpha and TRAF-2 expression levels in MI of the CLMN-treated mice were decreased, while IkBalpha was increased. HE staining showed CLMN reduced inflammation in mouse cardiomyocytes and decreased fibrosis. Conclusio …
An immunohistochemical analysis showed that the TNF-alpha and TRAF-2 expression levels in MI of the CLMN-treated mice were decreased, …
The all-trans retinoic acid (atRA)-regulated gene Calmin (Clmn) regulates cell cycle exit and neurite outgrowth in murine neuroblastoma (Neuro2a) cells.
Marzinke MA, Clagett-Dame M. Marzinke MA, et al. Exp Cell Res. 2012 Jan 1;318(1):85-93. doi: 10.1016/j.yexcr.2011.10.002. Epub 2011 Oct 6. Exp Cell Res. 2012. PMID: 22001116
In contrast, ectopic overexpression of Clmn produces an increase in the cyclin dependent kinase inhibitor, p21(Cip1), a decrease in cyclin D1 protein and an increase in hypophosphorylated Rb, showing that Clmn participates in G(1)/S arrest. Clmn overexpressio …
In contrast, ectopic overexpression of Clmn produces an increase in the cyclin dependent kinase inhibitor, p21(Cip1), a decrease in c …
A novel chemical ionization reagent ion for organic analytes: the aquachloromanganese(II) cation [ClMn(H2O)+].
Gqamana PP, Duan P, Fu M, Gallardo V, Kenttämaa HI. Gqamana PP, et al. Rapid Commun Mass Spectrom. 2012 Apr 30;26(8):940-2. doi: 10.1002/rcm.6187. Rapid Commun Mass Spectrom. 2012. PMID: 22396030
The reactivity of ClMn(H(2)O)(+) towards small organic compounds (L) was examined in a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. ...Based on these observations, the IE of ClMn(H(2)O)(+) is approximated to be 8.1 0.1 eV. Thus, the utilit …
The reactivity of ClMn(H(2)O)(+) towards small organic compounds (L) was examined in a Fourier transform ion cyclotron resonance (FT- …
Calmin expression in embryos and the adult brain, and its regulation by all-trans retinoic acid.
Marzinke MA, Henderson EM, Yang KS, See AW, Knutson DC, Clagett-Dame M. Marzinke MA, et al. Dev Dyn. 2010 Feb;239(2):610-9. doi: 10.1002/dvdy.22171. Dev Dyn. 2010. PMID: 20014094 Free article.
Using a subtracted cDNA library constructed from neuroblastoma cells, the atRA-responsive gene calmin (Clmn) was identified (Merrill et al. [2004] Biol Chem 385:605-614). The Clmn transcript is detected very early in rat embryonic development and is sensitive to ret …
Using a subtracted cDNA library constructed from neuroblastoma cells, the atRA-responsive gene calmin (Clmn) was identified (Merrill …
Analysis of base oil fractions by ClMn(H2O)+ chemical ionization combined with laser-induced acoustic desorption/fourier transform ion cyclotron resonance mass spectrometry.
Duan P, Qian K, Habicht SC, Pinkston DS, Fu M, Kenttämaa HI. Duan P, et al. Anal Chem. 2008 Mar 15;80(6):1847-53. doi: 10.1021/ac702476p. Epub 2008 Feb 22. Anal Chem. 2008. PMID: 18290675
Laser-induced acoustic desorption (LIAD), combined with chemical ionization with the ClMn(H(2)O)(+) ion, is demonstrated to facilitate the analysis of base oils by Fourier transform ion cyclotron resonance mass spectrometry. The LIAD/ClMn(H(2)O)(+) method produces o …
Laser-induced acoustic desorption (LIAD), combined with chemical ionization with the ClMn(H(2)O)(+) ion, is demonstrated to facilitat …
51 results