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Page 1
FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review).
Katoh M. Katoh M. Int J Mol Med. 2016 Jul;38(1):3-15. doi: 10.3892/ijmm.2016.2620. Epub 2016 May 31. Int J Mol Med. 2016. PMID: 27245147 Free PMC article. Review.
FGFR1 is relatively frequently amplified and overexpressed in breast and lung cancer, and FGFR2 in gastric cancer. BCR-FGFR1, CNTRL-FGFR1, CUX1-FGFR1, FGFR1OP-FGFR1, MYO18A-FGFR1 and ZMYM2-FGFR1 fusions in myeloproliferative neoplasms are non-receptor-type FGFR kinases, wh …
FGFR1 is relatively frequently amplified and overexpressed in breast and lung cancer, and FGFR2 in gastric cancer. BCR-FGFR1, CNTRL-F …
Genomic and phenotypic delineation of congenital microcephaly.
Shaheen R, Maddirevula S, Ewida N, Alsahli S, Abdel-Salam GMH, Zaki MS, Tala SA, Alhashem A, Softah A, Al-Owain M, Alazami AM, Abadel B, Patel N, Al-Sheddi T, Alomar R, Alobeid E, Ibrahim N, Hashem M, Abdulwahab F, Hamad M, Tabarki B, Alwadei AH, Alhazzani F, Bashiri FA, Kentab A, Şahintürk S, Sherr E, Fregeau B, Sogati S, Alshahwan SAM, Alkhalifi S, Alhumaidi Z, Temtamy S, Aglan M, Otaify G, Girisha KM, Tulbah M, Seidahmed MZ, Salih MA, Abouelhoda M, Momin AA, Saffar MA, Partlow JN, Arold ST, Faqeih E, Walsh C, Alkuraya FS. Shaheen R, et al. Genet Med. 2019 Mar;21(3):545-552. doi: 10.1038/s41436-018-0140-3. Epub 2018 Sep 14. Genet Med. 2019. PMID: 30214071 Free PMC article.
Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia.
Brown LM, Bartolo RC, Davidson NM, Schmidt B, Brooks I, Challis J, Petrovic V, Khuong-Quang DA, Mechinaud F, Khaw SL, Majewski IJ, Oshlack A, Ekert PG. Brown LM, et al. Pediatr Blood Cancer. 2019 Oct;66(10):e27897. doi: 10.1002/pbc.27897. Epub 2019 Jun 28. Pediatr Blood Cancer. 2019. PMID: 31250523
We report two patients with leukaemia driven by the rare CNTRL-FGFR1 fusion oncogene. This fusion arises from a t(8;9)(p12;q33) translocation, and is a rare driver of biphenotypic leukaemia in children. We used RNA sequencing to report novel features of expressed CNTRL …
We report two patients with leukaemia driven by the rare CNTRL-FGFR1 fusion oncogene. This fusion arises from a t(8;9)(p12;q33) trans …
Effects of Blood Flow Restriction Resistance Training on Autonomic and Endothelial Function in Persons with Parkinson's Disease.
Bane A, Wilson L, Jumper J, Spindler L, Wyatt P, Willoughby D. Bane A, et al. J Parkinsons Dis. 2024;14(4):761-775. doi: 10.3233/JPD-230259. J Parkinsons Dis. 2024. PMID: 38701159 Free PMC article. Clinical Trial.
METHODS: Thirty-eight PwPD were assigned LIRT-BFR, HIRT or to a control (CNTRL) group. The LIRT-BFR and HIRT groups exercised three days per week for four weeks. ...The HIRT group performed three sets of eight repetitions at 80% 1RM. The CNTRL group was asked to con …
METHODS: Thirty-eight PwPD were assigned LIRT-BFR, HIRT or to a control (CNTRL) group. The LIRT-BFR and HIRT groups exercised three d …
Aberrant expression of CNTRL was associated with poor prognosis, immune response and progression in glioma.
Mei X, Qin D, Zou M, Teng H, Zhai Y. Mei X, et al. Discov Oncol. 2025 May 9;16(1):706. doi: 10.1007/s12672-025-02531-1. Discov Oncol. 2025. PMID: 40343556 Free PMC article.
CNTRL expression levels were quantified using qRT-PCR. Functional analyses, including Gene Ontology and KEGG pathway enrichment, were conducted to elucidate the biological roles of CNTRL. ...Targeting CNTRL could represent a promising therapeutic strategy for …
CNTRL expression levels were quantified using qRT-PCR. Functional analyses, including Gene Ontology and KEGG pathway enrichment, were …
Empagliflozin mitigates ponatinib-induced cardiotoxicity by restoring the connexin 43-autophagy pathway.
Mattii L, Moscato S, Ippolito C, Polizzi E, Novo G, Zucchi R, De Caterina R, Ghelardoni S, Madonna R. Mattii L, et al. Biomed Pharmacother. 2024 Sep;178:117278. doi: 10.1016/j.biopha.2024.117278. Epub 2024 Aug 7. Biomed Pharmacother. 2024. PMID: 39116784 Free article.
METHODS AND RESULTS: Male C57BL/6 mice, randomized into four treatment groups (CNTRL, PON, EMPA, PON+EMPA) for 28 days, showed increased autophagy, decreased Cx43 expression as well as Cx43 lateralization, and attenuated systo-diastolic cardiac dysfunction after treatment …
METHODS AND RESULTS: Male C57BL/6 mice, randomized into four treatment groups (CNTRL, PON, EMPA, PON+EMPA) for 28 days, showed increa …
Co-Expression Network Analysis Identifies Molecular Determinants of Loneliness Associated with Neuropsychiatric and Neurodegenerative Diseases.
Santiago JA, Quinn JP, Potashkin JA. Santiago JA, et al. Int J Mol Sci. 2023 Mar 21;24(6):5909. doi: 10.3390/ijms24065909. Int J Mol Sci. 2023. PMID: 36982982 Free PMC article.
Nine switch genes, HLA-DRB5, ARHGAP15, COL4A1, RBM38, DMD, LGALS3BP, WSCD2, CYTH4, and CNTRL, overlapped with known genetic variants in depression. Seven switch genes, NPAS3, ARHGAP15, LGALS3BP, DPP10, SMYD3, CPXCR1, and HLA-DRB5 were associated with known risk factors for …
Nine switch genes, HLA-DRB5, ARHGAP15, COL4A1, RBM38, DMD, LGALS3BP, WSCD2, CYTH4, and CNTRL, overlapped with known genetic variants …
Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models.
Ren M, Qin H, Kitamura E, Cowell JK. Ren M, et al. Blood. 2013 Aug 8;122(6):1007-16. doi: 10.1182/blood-2013-03-489823. Epub 2013 Jun 18. Blood. 2013. PMID: 23777766 Free PMC article.
Molecular genetic analyses of these model mice, as well as primary human disease, demonstrated that CNTRL-FGFR1, through abnormal activation of several signaling pathways related to development and differentiation of both myeloid and T-lymphoid cells, contribute to overt l …
Molecular genetic analyses of these model mice, as well as primary human disease, demonstrated that CNTRL-FGFR1, through abnormal act …
Intramammary 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 treatments differentially increase serum calcium and milk cell gene expression.
Wells TL, Poindexter MB, Kweh MF, Blakely LP, Nelson CD. Wells TL, et al. JDS Commun. 2022 Dec 14;4(2):91-96. doi: 10.3168/jdsc.2022-0336. eCollection 2023 Mar. JDS Commun. 2022. PMID: 36974222 Free PMC article.
The 1,25D treatments increased serum concentrations of 1,25D and Ca in a dose-dependent manner with maximum 1,25D and Ca concentrations of 199 6 pg/mL and 2.73 0.04 mM, respectively, observed for 50 mug of 1,25D cows compared with 59 6 pg/mL and 2.54 mM, respectively, for CNTR …
The 1,25D treatments increased serum concentrations of 1,25D and Ca in a dose-dependent manner with maximum 1,25D and Ca concentrations of 1 …
84 results