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Page 1
Genetic risk factors for COVID-19 and influenza are largely distinct.
Kosmicki JA, Marcketta A, Sharma D, Di Gioia SA, Batista S, Yang XM, Tzoneva G, Martinez H, Sidore C, Kessler MD, Horowitz JE, Roberts GHL, Justice AE, Banerjee N, Coignet MV, Leader JB, Park DS, Lanche R, Maxwell E, Knight SC, Bai X, Guturu H, Baltzell A, Girshick AR, McCurdy SR, Partha R, Mansfield AJ, Turissini DA, Zhang M, Mbatchou J, Watanabe K, Verma A, Sirugo G; Colorado Center for Precision Medicine; Mayo Clinic Project Generation; Regeneron Genetics Center; University of California Los Angeles ATLAS Collaboration; Ritchie MD, Salerno WJ, Shuldiner AR, Rader DJ, Mirshahi T, Marchini J, Overton JD, Carey DJ, Habegger L, Reid JG, Economides A, Kyratsous C, Karalis K, Baum A, Cantor MN, Rand KA, Hong EL, Ball CA, Siminovitch K, Baras A, Abecasis GR, Ferreira MAR. Kosmicki JA, et al. Among authors: coignet mv. Nat Genet. 2024 Aug;56(8):1592-1596. doi: 10.1038/s41588-024-01844-1. Epub 2024 Aug 5. Nat Genet. 2024. PMID: 39103650 Free PMC article.
Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects.
Roberts GHL, Partha R, Rhead B, Knight SC, Park DS, Coignet MV, Zhang M, Berkowitz N, Turrisini DA, Gaddis M, McCurdy SR, Pavlovic M, Ruiz L, Sass C; AncestryDNA Science Team; Haug Baltzell AK, Guturu H, Girshick AR, Ball CA, Hong EL, Rand KA. Roberts GHL, et al. Among authors: coignet mv. Nat Genet. 2022 Apr;54(4):374-381. doi: 10.1038/s41588-022-01042-x. Epub 2022 Apr 11. Nat Genet. 2022. PMID: 35410379
COVID-19 susceptibility and severity risks in a cross-sectional survey of over 500 000 US adults.
Knight SC, McCurdy SR, Rhead B, Coignet MV, Park DS, Roberts GHL, Berkowitz ND, Zhang M, Turissini D, Delgado K, Pavlovic M; AncestryDNA Science Team; Haug Baltzell AK, Guturu H, Rand KA, Girshick AR, Hong EL, Ball CA. Knight SC, et al. Among authors: coignet mv. BMJ Open. 2022 Oct 12;12(10):e049657. doi: 10.1136/bmjopen-2021-049657. BMJ Open. 2022. PMID: 36223959 Free PMC article.
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease.
Horowitz JE, Kosmicki JA, Damask A, Sharma D, Roberts GHL, Justice AE, Banerjee N, Coignet MV, Yadav A, Leader JB, Marcketta A, Park DS, Lanche R, Maxwell E, Knight SC, Bai X, Guturu H, Sun D, Baltzell A, Kury FSP, Backman JD, Girshick AR, O'Dushlaine C, McCurdy SR, Partha R, Mansfield AJ, Turissini DA, Li AH, Zhang M, Mbatchou J, Watanabe K, Gurski L, McCarthy SE, Kang HM, Dobbyn L, Stahl E, Verma A, Sirugo G; Regeneron Genetics Center; Ritchie MD, Jones M, Balasubramanian S, Siminovitch K, Salerno WJ, Shuldiner AR, Rader DJ, Mirshahi T, Locke AE, Marchini J, Overton JD, Carey DJ, Habegger L, Cantor MN, Rand KA, Hong EL, Reid JG, Ball CA, Baras A, Abecasis GR, Ferreira MAR. Horowitz JE, et al. Among authors: coignet mv. Nat Genet. 2022 Apr;54(4):382-392. doi: 10.1038/s41588-021-01006-7. Epub 2022 Mar 3. Nat Genet. 2022. PMID: 35241825 Free PMC article.
Targeting CD38 with daratumumab is lethal to Waldenström macroglobulinaemia cells.
Paulus A, Manna A, Akhtar S, Paulus SM, Sharma M, Coignet MV, Jiang L, Roy V, Witzig TE, Ansell SM, Allan J, Furman R, Aulakh S, Manochakian R, Ailawadhi S, Chanan-Khan AA, Sher T. Paulus A, et al. Among authors: coignet mv. Br J Haematol. 2018 Oct;183(2):196-211. doi: 10.1111/bjh.15515. Epub 2018 Aug 6. Br J Haematol. 2018. PMID: 30080238 Free PMC article.
Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease.
Horowitz JE, Kosmicki JA, Damask A, Sharma D, Roberts GHL, Justice AE, Banerjee N, Coignet MV, Yadav A, Leader JB, Marcketta A, Park DS, Lanche R, Maxwell E, Knight SC, Bai X, Guturu H, Sun D, Baltzell A, Kury FSP, Backman JD, Girshick AR, O'Dushlaine C, McCurdy SR, Partha R, Mansfield AJ, Turissini DA, Li AH, Zhang M, Mbatchou J, Watanabe K, Gurski L, McCarthy SE, Kang HM, Dobbyn L, Stahl E, Verma A, Sirugo G; Regeneron Genetics Center; Ritchie MD, Jones M, Balasubramanian S, Siminovitch K, Salerno WJ, Shuldiner AR, Rader DJ, Mirshahi T, Locke AE, Marchini J, Overton JD, Carey DJ, Habegger L, Cantor MN, Rand KA, Hong EL, Reid JG, Ball CA, Baras A, Abecasis GR, Ferreira MA. Horowitz JE, et al. Among authors: coignet mv. medRxiv [Preprint]. 2021 Jun 10:2020.12.14.20248176. doi: 10.1101/2020.12.14.20248176. medRxiv. 2021. Update in: Nat Genet. 2022 Apr;54(4):382-392. doi: 10.1038/s41588-021-01006-7. PMID: 33619501 Free PMC article. Updated. Preprint.
Genetic ancestry and population differences in levels of inflammatory cytokines in women: Role for evolutionary selection and environmental factors.
Yao S, Hong CC, Ruiz-Narváez EA, Evans SS, Zhu Q, Schaefer BA, Yan L, Coignet MV, Lunetta KL, Sucheston-Campbell LE, Lee K, Bandera EV, Troester MA, Rosenberg L, Palmer JR, Olshan AF, Ambrosone CB. Yao S, et al. Among authors: coignet mv. PLoS Genet. 2018 Jun 7;14(6):e1007368. doi: 10.1371/journal.pgen.1007368. eCollection 2018 Jun. PLoS Genet. 2018. PMID: 29879116 Free PMC article.