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Year Number of Results
2006 2
2007 1
2008 1
2009 5
2010 3
2020 1
2021 2
2023 0

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Page 1
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Vargas HM, Rolf MG, Wisialowski TA, Achanzar W, Bahinski A, Bass A, Benson CT, Chaudhary KW, Couvreur N, Dota C, Engwall MJ, Michael Foley C, Gallacher D, Greiter-Wilke A, Guillon JM, Guth B, Himmel HM, Hegele-Hartung C, Ito M, Jenkinson S, Chiba K, Lagrutta A, Levesque P, Martel E, Okai Y, Peri R, Pointon A, Qu Y, Teisman A, Traebert M, Yoshinaga T, Gintant GA, Leishman DJ, Valentin JP. Vargas HM, et al. Among authors: couvreur n. Clin Pharmacol Ther. 2021 Feb;109(2):310-318. doi: 10.1002/cpt.2029. Epub 2020 Sep 24. Clin Pharmacol Ther. 2021. PMID: 32866317 Free PMC article. Review.
Pharmacological postconditioning with the phytoestrogen genistein.
Tissier R, Waintraub X, Couvreur N, Gervais M, Bruneval P, Mandet C, Zini R, Enriquez B, Berdeaux A, Ghaleh B. Tissier R, et al. Among authors: couvreur n. J Mol Cell Cardiol. 2007 Jan;42(1):79-87. doi: 10.1016/j.yjmcc.2006.10.007. Epub 2006 Dec 1. J Mol Cell Cardiol. 2007. PMID: 17141266
Rapid cooling preserves the ischaemic myocardium against mitochondrial damage and left ventricular dysfunction.
Tissier R, Couvreur N, Ghaleh B, Bruneval P, Lidouren F, Morin D, Zini R, Bize A, Chenoune M, Belair MF, Mandet C, Douheret M, Dubois-Rande JL, Parker JC, Cohen MV, Downey JM, Berdeaux A. Tissier R, et al. Among authors: couvreur n. Cardiovasc Res. 2009 Jul 15;83(2):345-53. doi: 10.1093/cvr/cvp046. Epub 2009 Feb 5. Cardiovasc Res. 2009. PMID: 19196828 Free PMC article.
The ceiling effect of pharmacological postconditioning with the phytoestrogen genistein is reversed by the GSK3beta inhibitor SB 216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] through mitochondrial ATP-dependent potassium channel opening.
Couvreur N, Tissier R, Pons S, Chenoune M, Waintraub X, Berdeaux A, Ghaleh B. Couvreur N, et al. J Pharmacol Exp Ther. 2009 Jun;329(3):1134-41. doi: 10.1124/jpet.109.152587. Epub 2009 Mar 24. J Pharmacol Exp Ther. 2009. PMID: 19318592
Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect and a long-term increase in FKBP12/12.6 expression.
Couvreur N, Tissier R, Pons S, Chetboul V, Gouni V, Bruneval P, Mandet C, Pouchelon JL, Berdeaux A, Ghaleh B. Couvreur N, et al. Eur Heart J. 2010 Jun;31(12):1529-37. doi: 10.1093/eurheartj/ehp554. Epub 2009 Dec 21. Eur Heart J. 2010. PMID: 20028694 Free PMC article.
11 results