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Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4.
Wolff DW, Deng Z, Bianchi-Smiraglia A, Foley CE, Han Z, Wang X, Shen S, Rosenberg MM, Moparthy S, Yun DH, Chen J, Baker BK, Roll MV, Magiera AJ, Li J, Hurley E, Feltri ML, Cox AO, Lee J, Furdui CM, Liu L, Bshara W, LaConte LEW, Kandel ES, Pasquale EB, Qu J, Hedstrom L, Nikiforov MA. Wolff DW, et al. Among authors: cox ao. Cell Chem Biol. 2022 Jun 16;29(6):970-984.e6. doi: 10.1016/j.chembiol.2022.01.007. Epub 2022 Feb 10. Cell Chem Biol. 2022. PMID: 35148834 Free PMC article.
An FDA-Approved Antifungal, Ketoconazole, and Its Novel Derivative Suppress tGLI1-Mediated Breast Cancer Brain Metastasis by Inhibiting the DNA-Binding Activity of Brain Metastasis-Promoting Transcription Factor tGLI1.
Doheny D, Manore S, Sirkisoon SR, Zhu D, Aguayo NR, Harrison A, Najjar M, Anguelov M, Cox AO, Furdui CM, Watabe K, Hollis T, Thomas A, Strowd R, Lo HW. Doheny D, et al. Among authors: cox ao. Cancers (Basel). 2022 Aug 31;14(17):4256. doi: 10.3390/cancers14174256. Cancers (Basel). 2022. PMID: 36077791 Free PMC article.