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CPSF1 mediates retinal vascular dysfunction in diabetes mellitus via the MAPK/ERK pathway.
Zhang J, Zhang X, Zou Y, Han F. Zhang J, et al. Arch Physiol Biochem. 2022 Jun;128(3):708-715. doi: 10.1080/13813455.2020.1722704. Epub 2020 Feb 12. Arch Physiol Biochem. 2022. PMID: 32046510
Adeno-associated viral CPSF1 attenuated histological abnormalities of retinas. CPSF1 regulates the apoptosis, migration, and vascularisation of HRVECs under HG conditions in vitro. ...In conclusion, CPSF1 may be associated with the development of DR, and upre …
Adeno-associated viral CPSF1 attenuated histological abnormalities of retinas. CPSF1 regulates the apoptosis, migration, and v …
CPSF1 positively regulates NSDHL by alternative polyadenylation and promotes gastric cancer progression.
Kang W, Yang Y, Chen C, Yu C. Kang W, et al. Am J Cancer Res. 2022 Oct 15;12(10):4566-4583. eCollection 2022. Am J Cancer Res. 2022. PMID: 36381317 Free PMC article.
Nevertheless, the roles and underlying mechanisms of CPSF1 remain unclear in GC. In this work, we identified that CPSF1 is significantly upregulated in GC and that high CPSF1 expression indicates an unfavourable prognosis in GC patients. ...CPSF1 deple …
Nevertheless, the roles and underlying mechanisms of CPSF1 remain unclear in GC. In this work, we identified that CPSF1 is sig …
Circ-CPSF1 Worsens Radiation-Induced Oxidative Stress Injury in Caenorhabditis elegans.
Yuan J, Lin F, Wu Z, Jiang Z, Wang T, Huo S, Lai W, Li L, Zhang C. Yuan J, et al. Biomolecules. 2023 Jan 4;13(1):102. doi: 10.3390/biom13010102. Biomolecules. 2023. PMID: 36671487 Free PMC article.
Circ-CPSF1 was screened out and its up-regulated expression was verified. ...ROS levels were significantly reduced after the interference of circ-CPSF1 in C. elegans with radiation. Mitochondrial membrane potential assay showed that the suppression of circ-CPSF1
Circ-CPSF1 was screened out and its up-regulated expression was verified. ...ROS levels were significantly reduced after the interfer …
ABL kinases regulate the stabilization of HIF-1alpha and MYC through CPSF1.
Mayro B, Hoj JP, Cerda-Smith CG, Hutchinson HM, Caminear MW, Thrash HL, Winter PS, Wardell SE, McDonnell DP, Wu C, Wood KC, Pendergast AM. Mayro B, et al. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2210418120. doi: 10.1073/pnas.2210418120. Epub 2023 Apr 11. Proc Natl Acad Sci U S A. 2023. PMID: 37040401 Free PMC article.
Further, we identified the MYC proto-oncogene protein as a second CPSF1 substrate and show that active ABL kinase protects MYC from CPSF1-mediated degradation. These studies uncover a role for CPSF1 in cancer pathobiology as an E3-ligase antagonizing the expr …
Further, we identified the MYC proto-oncogene protein as a second CPSF1 substrate and show that active ABL kinase protects MYC from …
CPSF1 mutations are associated with early-onset high myopia and involved in retinal ganglion cell axon projection.
Ouyang J, Sun W, Xiao X, Li S, Jia X, Zhou L, Wang P, Zhang Q. Ouyang J, et al. Hum Mol Genet. 2019 Jun 15;28(12):1959-1970. doi: 10.1093/hmg/ddz029. Hum Mol Genet. 2019. PMID: 30689892 Free PMC article.
Clinical data demonstrated eoHM in the six probands with these mutations. Knockdown of cpsf1 by morpholino oligonucleotide (MO) injection in zebrafish eggs resulted in small eye size in 84.38% of the injected larvae, and this phenotype was rescued in 61.39% of the zebrafis …
Clinical data demonstrated eoHM in the six probands with these mutations. Knockdown of cpsf1 by morpholino oligonucleotide (MO) injec …
Aberrant expression of CPSF1 promotes head and neck squamous cell carcinoma via regulating alternative splicing.
Sakai A, Ando M, Fukusumi T, Ren S, Liu C, Qualliotine J, Haft S, Sadat S, Saito Y, Guo TW, Xu G, Sasik R, Fisch KM, Gutkind JS, Fertig EJ, Molinolo AA, Califano JA. Sakai A, et al. PLoS One. 2020 May 21;15(5):e0233380. doi: 10.1371/journal.pone.0233380. eCollection 2020. PLoS One. 2020. PMID: 32437477 Free PMC article.
We employed knockdown and overexpression assays followed by identification of ASEs regulated by CPSF1 overexpression to identify changes in ASEs, and the expression of these ASEs was validated using RNA from cell line models. Alterations in expression of spliceosome genes, …
We employed knockdown and overexpression assays followed by identification of ASEs regulated by CPSF1 overexpression to identify chan …
cpsf1 is required for definitive HSC survival in zebrafish.
Bolli N, Payne EM, Rhodes J, Gjini E, Johnston AB, Guo F, Lee JS, Stewart RA, Kanki JP, Chen AT, Zhou Y, Zon LI, Look AT. Bolli N, et al. Blood. 2011 Apr 14;117(15):3996-4007. doi: 10.1182/blood-2010-08-304030. Epub 2011 Feb 17. Blood. 2011. PMID: 21330472 Free PMC article.
However, when HSCs migrate to the caudal hematopoietic tissue at 3 days postfertilization, their numbers start decreasing as a result of apoptotic cell death. Consistent with Cpsf1 function, c-myb:EGFP(+) cells in grechetto mutants also show defective polyadenylation of sn …
However, when HSCs migrate to the caudal hematopoietic tissue at 3 days postfertilization, their numbers start decreasing as a result of apo …
m(6)A-induced repression of SIAH1 facilitates alternative splicing of androgen receptor variant 7 by regulating CPSF1.
Xia L, Han Q, Duan X, Zhu Y, Pan J, Dong B, Xia W, Xue W, Sha J. Xia L, et al. Mol Ther Nucleic Acids. 2022 Mar 15;28:219-230. doi: 10.1016/j.omtn.2022.03.008. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35402071 Free PMC article.
SIAH1 repressed PCa cell growth and invasion under castrate conditions. SIAH1 directly interacted with CPSF1 and promoted ubiquitination and degradation of CPSF1. CPSF1 expression was negatively correlated with SIAH1 expression, but positively with PCa progre …
SIAH1 repressed PCa cell growth and invasion under castrate conditions. SIAH1 directly interacted with CPSF1 and promoted ubiquitinat …
Mutational screening of AGRN, SLC39A5, SCO2, P4HA2, BSG, ZNF644, and CPSF1 in a Chinese cohort of 103 patients with nonsyndromic high myopia.
Zheng YH, Cai XB, Xia LQ, Zhou FY, Wen XR, Chen DF, Han F, Zhou KJ, Jin ZB, Zhuang WJ, Lin B. Zheng YH, et al. Mol Vis. 2021 Dec 7;27:706-717. eCollection 2021. Mol Vis. 2021. PMID: 35002215 Free PMC article.
A total of eight heterozygous variants potentially affecting the protein function were detected in eight of the remaining 99 patients, including c.1350delC, p.V451Cfs*76 and c.1023_1024insA, p.P342Tfs*41 in SLC39A5; c.244_246delAAG, p.K82del in SCO2; c.545A>G, p.Y182C in P4HA2 …
A total of eight heterozygous variants potentially affecting the protein function were detected in eight of the remaining 99 patients, inclu …
Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.
Evsyukova I, Bradrick SS, Gregory SG, Garcia-Blanco MA. Evsyukova I, et al. RNA. 2013 Jan;19(1):103-15. doi: 10.1261/rna.035410.112. Epub 2012 Nov 14. RNA. 2013. PMID: 23151878 Free PMC article.
Mutations to this site and CPSF1 knockdown both resulted in an increase in exon 6 inclusion. We found no evidence that this site is used to produce cleaved and polyadenylated mRNAs, suggesting that CPSF1 interaction with intronic IL7R pre-mRNA interferes with splice …
Mutations to this site and CPSF1 knockdown both resulted in an increase in exon 6 inclusion. We found no evidence that this site is u …
40 results