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456 results

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Page 1
Naoqing formula alleviates cerebral ischemia/reperfusion injury induced inflammatory injury by regulating Csf3 mediated JAK/STAT pathway and macrophage polarization.
Ye Y, Rao Z, Xie X, Liu Y, Qiu L, Liu Q, Weng X, Wang C, Bi Y, Zeng T. Ye Y, et al. Phytomedicine. 2025 May;140:156626. doi: 10.1016/j.phymed.2025.156626. Epub 2025 Mar 9. Phytomedicine. 2025. PMID: 40088744 Free article.
Notably, in CIRI mice treated with NQ, there was a notable downregulation of Csf3, JAK2, STAT3, and STAT6, along with a co-localization of Csf3 and CD206. These observations suggested that NQ inhibited the activation of the JAK/STAT pathway and exerted its anti-infl …
Notably, in CIRI mice treated with NQ, there was a notable downregulation of Csf3, JAK2, STAT3, and STAT6, along with a co-localizati …
CSF3 aggravates acute exacerbation of pulmonary fibrosis by disrupting alveolar epithelial barrier integrity.
Guo B, Liu W, Ji X, Xi B, Meng X, Xie W, Sun Y, Zhang M, Liu P, Zhang W, Yan X, Chen B. Guo B, et al. Int Immunopharmacol. 2024 Jun 30;135:112322. doi: 10.1016/j.intimp.2024.112322. Epub 2024 May 23. Int Immunopharmacol. 2024. PMID: 38788452
Transcriptomic profiling of pulmonary tissues identified CSF3 as one of the top 10 upregulated DEGs in AE-PF mice. Indeed, administration of exogenous CSF3 protein exacerbated AE-PF in mice. ...Pearson correlation analysis in IPF patients revealed significant positi …
Transcriptomic profiling of pulmonary tissues identified CSF3 as one of the top 10 upregulated DEGs in AE-PF mice. Indeed, administra …
Harmine alleviates LPS-induced acute lung injury by inhibiting CSF3-mediated MAPK/NF-kappaB signaling pathway.
Zhai Y, Chen K, Xu Z, Chen X, Tong J, He Y, Chen C, Ding M, Liang G, Zheng X. Zhai Y, et al. Respir Res. 2025 Mar 28;26(1):119. doi: 10.1186/s12931-025-03196-8. Respir Res. 2025. PMID: 40156005 Free PMC article.
Mechanically, the findings revealed that harmine does not disrupt the TLR4-MD2 interaction but instead attenuates inflammation by suppressing CSF3 transcription and expression, leading to the inhibition of the MAPK/NF-kappaB signaling pathway activation induced by LPS stim …
Mechanically, the findings revealed that harmine does not disrupt the TLR4-MD2 interaction but instead attenuates inflammation by suppressin …
Cancer-associated fibroblasts secrete CSF3 to promote TNBC progression via enhancing PGM2L1-dependent glycolysis reprogramming.
Qin W, Chen B, Li X, Zhao W, Wang L, Zhang N, Wang X, Luo D, Liang Y, Li Y, Chen X, Chen T, Yang Q. Qin W, et al. Cell Death Dis. 2025 Apr 4;16(1):249. doi: 10.1038/s41419-025-07580-6. Cell Death Dis. 2025. PMID: 40185722 Free PMC article.
This study employed a bead-based multiplex immunoassay to analyze a panel of cytokines/chemokines and identified colony stimulating factor 3 (CSF3) as a significantly elevated component in the secretome of hypoxic CAFs. We found that CSF3 promoted the invasive behav …
This study employed a bead-based multiplex immunoassay to analyze a panel of cytokines/chemokines and identified colony stimulating factor 3 …
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.
Cai W, Hu M, Li C, Wu R, Lu D, Xie C, Zhang W, Li T, Shen S, Huang H, Qiu W, Liu Q, Lu Y, Lu Z. Cai W, et al. Autophagy. 2023 Apr;19(4):1144-1163. doi: 10.1080/15548627.2022.2116833. Epub 2022 Sep 28. Autophagy. 2023. PMID: 36170234 Free PMC article.
Our data demonstrate a distinct set of FOXP3+ macrophages with enhanced scavenging capability, which could be a target in immunomodulatory therapy against AIS.Abbreviations: ADGRE1/F4/80: adhesion G protein-coupled receptor E1; AIF1/Iba1: allograft inflammatory factor 1; AIS: acu …
Our data demonstrate a distinct set of FOXP3+ macrophages with enhanced scavenging capability, which could be a target in immunomodulatory t …
Human 'knockouts' of CSF3 display severe congenital neutropenia.
Khouj E, Marafi D, Aljamal B, Hajiya A, Elshafie RM, Hashem MO, Abdulwahab F, Jaafar A, Alshidi T, Aboelanine AH, Awaji A, Alkuraya FS. Khouj E, et al. Br J Haematol. 2023 Nov;203(3):477-480. doi: 10.1111/bjh.19054. Epub 2023 Aug 23. Br J Haematol. 2023. PMID: 37612131
Complete deficiency of CSF3 as a result of nonsense-mediated decay (NMD) could be demonstrated on RT-PCR using skin fibroblasts-derived RNA. The phenotype observed in this cohort mirrors that documented in mouse and zebrafish models of CSF3 deficiency. Our results s …
Complete deficiency of CSF3 as a result of nonsense-mediated decay (NMD) could be demonstrated on RT-PCR using skin fibroblasts-deriv …
CSF3 enhances the innate immune responses to ALV-J infections via NF-kappaB and interferon pathways.
Xia J, Chen W, Xu C, Wang M, Mo G, Zhang X. Xia J, et al. Poult Sci. 2025 Nov;104(11):105648. doi: 10.1016/j.psj.2025.105648. Epub 2025 Aug 6. Poult Sci. 2025. PMID: 40812136 Free PMC article.
Phylogenetic analysis showed that avian and mammalian CSF3 genes clustered separately within the phylogenetic tree. Subsequently, we overexpressed and silenced CSF3 in DF-1 cells followed by ALV-J infection. ...Notably, the pro-inflammatory and antiviral effects of …
Phylogenetic analysis showed that avian and mammalian CSF3 genes clustered separately within the phylogenetic tree. Subsequently, we …
CSF3 promotes colorectal cancer progression by activating p65/NF-kappaB signaling pathway and inducing an immunosuppressive microenvironment.
Xu J, Li N, Xie H, Duan C, Liao X, Li R, Zhang H, Pan Y, Ma X, Du S, Sheng J, Wang X, Yang L, Jin P. Xu J, et al. Transl Oncol. 2025 Mar;53:102310. doi: 10.1016/j.tranon.2025.102310. Epub 2025 Feb 9. Transl Oncol. 2025. PMID: 39929064 Free PMC article.
However, the functional importance of CSF3 in colorectal cancer (CRC) remains unclear. METHODS: CSF3 expression levels in CRC cells and tissues were detected by quantitative real-time PCR (qRT-PCR), western blot and immunohistochemistry (IHC). ...Mechanistically, …
However, the functional importance of CSF3 in colorectal cancer (CRC) remains unclear. METHODS: CSF3 expression levels in CRC …
CSF3 Is a Potential Drug Target for the Treatment of COVID-19.
Fang C, Mei J, Tian H, Liou YL, Rong D, Zhang W, Liao Q, Wu N. Fang C, et al. Front Physiol. 2021 Jan 22;11:605792. doi: 10.3389/fphys.2020.605792. eCollection 2020. Front Physiol. 2021. PMID: 33551833 Free PMC article.
The results showed that in human bronchial organoids, A549, Calu3, and NHBE samples infected with SARS-CoV-2, only one upregulated gene CSF3 was identified. Interestingly, CSF3 is one of the hub genes we previously screened in GSE150819, suggesting that CSF3 …
The results showed that in human bronchial organoids, A549, Calu3, and NHBE samples infected with SARS-CoV-2, only one upregulated gene C …
Truncated CSF3 receptors induce pro-inflammatory responses in severe congenital neutropenia.
Olofsen PA, Bosch DA, de Looper HWJ, van Strien PMH, Hoogenboezem RM, Roovers O, van der Velden VHJ, Bindels EMJ, De Pater EM, Touw IP. Olofsen PA, et al. Br J Haematol. 2023 Jan;200(1):79-86. doi: 10.1111/bjh.18477. Epub 2022 Sep 28. Br J Haematol. 2023. PMID: 36168923 Free PMC article.
Introduction and activation of CSF3R truncation mutants in normal HPCs causes a clonally dominant myeloproliferative state in mice treated with CSF3. Paradoxically, in SCN patients receiving CSF3 therapy, clonal dominance of CSF3R mutant clones usually occurs only a …
Introduction and activation of CSF3R truncation mutants in normal HPCs causes a clonally dominant myeloproliferative state in mice treated w …
456 results