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48 results

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Page 1
CTNNBL1 restricts HIV-1 replication by suppressing viral DNA integration into the cell genome.
Liang G, He Y, Zhao L, Ouyang J, Geng W, Zhang X, Han X, Jiang Y, Ding H, Xiong Y, Dong J, Liu M, Shang H. Liang G, et al. Cell Rep. 2022 Mar 15;38(11):110533. doi: 10.1016/j.celrep.2022.110533. Cell Rep. 2022. PMID: 35294870 Free article.
CTNNBL1 overexpression blocks HIV-1 integration and inhibits viral replication, whereas CTNNBL1 depletion significantly upregulates HIV-1 integration into the genome of various target cells. Further, CTNNBL1 expression is downregulated in CD4(+) T cells by ac …
CTNNBL1 overexpression blocks HIV-1 integration and inhibits viral replication, whereas CTNNBL1 depletion significantly upregu …
Disease-associated CTNNBL1 mutation impairs somatic hypermutation by decreasing nuclear AID.
Kuhny M, Forbes LR, Çakan E, Vega-Loza A, Kostiuk V, Dinesh RK, Glauzy S, Stray-Pedersen A, Pezzi AE, Hanson IC, Vargas-Hernandez A, Xu ML, Coban-Akdemir ZH, Jhangiani SN, Muzny DM, Gibbs RA, Lupski JR, Chinn IK, Schatz DG, Orange JS, Meffre E. Kuhny M, et al. J Clin Invest. 2020 Aug 3;130(8):4411-4422. doi: 10.1172/JCI131297. J Clin Invest. 2020. PMID: 32484799 Free PMC article.
We identified a CVID+AIC patient who displays a rare homozygous missense M466V mutation in beta-catenin-like protein 1 (CTNNBL1). Because CTNNBL1 binds activation-induced cytidine deaminase (AID) that catalyzes SHM, we tested AID interactions with the CTNNBL1 …
We identified a CVID+AIC patient who displays a rare homozygous missense M466V mutation in beta-catenin-like protein 1 (CTNNBL1). Bec …
Spliceosome-associated factor CTNNBL1 promotes proliferation and invasion in ovarian cancer.
Li Y, Guo H, Jin C, Qiu C, Gao M, Zhang L, Liu Z, Kong B. Li Y, et al. Exp Cell Res. 2017 Aug 1;357(1):124-134. doi: 10.1016/j.yexcr.2017.05.008. Epub 2017 May 10. Exp Cell Res. 2017. PMID: 28501461
In this study, we demonstrated that spliceosome-associated factor CTNNBL1 was significantly upregulated in high-grade serous ovarian carcinoma, the elevated level of CTNNBL1 indicates poor prognosis in patients with high-grade serous ovarian carcinoma. ...Importantl …
In this study, we demonstrated that spliceosome-associated factor CTNNBL1 was significantly upregulated in high-grade serous ovarian …
CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex.
van Maldegem F, Maslen S, Johnson CM, Chandra A, Ganesh K, Skehel M, Rada C. van Maldegem F, et al. Nucleic Acids Res. 2015 Aug 18;43(14):7058-69. doi: 10.1093/nar/gkv643. Epub 2015 Jun 29. Nucleic Acids Res. 2015. PMID: 26130721 Free PMC article.
Using amine crosslinking and hydrogen-deuterium exchange coupled to mass spectrometry, we describe the architecture of the Prp19 sub-complex that contains CTNNBL1. Deficiency in CTNNBL1 leads to delayed initiation of cell division and embryonic lethality. Here we sh …
Using amine crosslinking and hydrogen-deuterium exchange coupled to mass spectrometry, we describe the architecture of the Prp19 sub-complex …
CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.
Ganesh K, Adam S, Taylor B, Simpson P, Rada C, Neuberger M. Ganesh K, et al. J Biol Chem. 2011 May 13;286(19):17091-102. doi: 10.1074/jbc.M110.208769. Epub 2011 Mar 8. J Biol Chem. 2011. PMID: 21385873 Free PMC article.
We find that CTNNBL1 association with the Prp19 complex is mediated by recognition of the NLS of the CDC5L component of the complex and show that CTNNBL1 also interacts with Prp31 (another U4/U6.U5 tri-snRNP-associated splicing factor) through its NLS. ...Furthermor …
We find that CTNNBL1 association with the Prp19 complex is mediated by recognition of the NLS of the CDC5L component of the complex a …
Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination.
Han L, Masani S, Yu K. Han L, et al. J Immunol. 2010 Aug 1;185(3):1379-81. doi: 10.4049/jimmunol.1001643. Epub 2010 Jun 28. J Immunol. 2010. PMID: 20585033 Free PMC article.
To directly assess the role of CTNNBL1 in CSR, we disrupted the CTNNBL1 gene on both alleles in mouse CH12F3 cells by gene targeting. We found normal levels of CSR in CTNNBL1-deficient cells, indicating that CTNNBL1 is dispensable for CSR....
To directly assess the role of CTNNBL1 in CSR, we disrupted the CTNNBL1 gene on both alleles in mouse CH12F3 cells by gene tar …
Alternative splicing in ovarian cancer.
Wei L, Li Y, Chen J, Wang Y, Wu J, Yang H, Zhang Y. Wei L, et al. Cell Commun Signal. 2024 Oct 18;22(1):507. doi: 10.1186/s12964-024-01880-8. Cell Commun Signal. 2024. PMID: 39425166 Free PMC article. Review.
We begin with an overview of altered splicing machinery, highlighting increased expression of spliceosome components and associated splicing factors like BUD31, SF3B4, and CTNNBL1, and their relationships to ovarian cancer. Next, we summarize the impact of specific variant …
We begin with an overview of altered splicing machinery, highlighting increased expression of spliceosome components and associated splicing …
Small angle X-ray scattering studies of CTNNBL1 dimerization and CTNNBL1/CDC5L complex.
Ahn JW, Jin KS, Son HF, Chang JH, Kim KJ. Ahn JW, et al. Sci Rep. 2015 Sep 18;5:14251. doi: 10.1038/srep14251. Sci Rep. 2015. PMID: 26381213 Free PMC article.
We also found that the positively-charged NLS3-containing region (residues 197-235) of CDC5L bound to the negatively-charged patch of CTNNBL1 and that the CTNNBL1/CDC5L complex formed a heterotetramer consisting of one CTNNBL1 dimer and one CDC5L dimer. Moreo …
We also found that the positively-charged NLS3-containing region (residues 197-235) of CDC5L bound to the negatively-charged patch of CTN …
Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex.
Ahn JW, Kim S, Kim EJ, Kim YJ, Kim KJ. Ahn JW, et al. Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):780-8. doi: 10.1107/S139900471303318X. Epub 2014 Feb 22. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24598747 Free article.
In order to elucidate the molecular architecture of the hPrp19-CDC5L complex, the crystal structure of CTNNBL1, one of the major components of this complex, was determined. Unlike canonical ARM-repeat proteins such as beta-catenin and importin-alpha, CTNNBL1 was fou …
In order to elucidate the molecular architecture of the hPrp19-CDC5L complex, the crystal structure of CTNNBL1, one of the major comp …
No association between CTNNBL1 and episodic memory performance.
Liu T, Li SC, Papenberg G, Schröder J, Roehr JT, Nietfeld W, Lindenberger U, Bertram L. Liu T, et al. Transl Psychiatry. 2014 Sep 30;4(9):e454. doi: 10.1038/tp.2014.93. Transl Psychiatry. 2014. PMID: 25268258 Free PMC article.
To further examine the genetic effects of CTNNBL1, we tested for association between 455 single-nucleotide polymorphisms (SNPs) in or near CTNNBL1 and 14 measures of episodic memory performance from three different tasks in 1743 individuals. ...More studies are need …
To further examine the genetic effects of CTNNBL1, we tested for association between 455 single-nucleotide polymorphisms (SNPs) in or …
48 results