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498 results

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Page 1
CUX1-related neurodevelopmental disorder: deep insights into phenotype-genotype spectrum and underlying pathology.
Oppermann H, Marcos-Grañeda E, Weiss LA, Gurnett CA, Jelsig AM, Vineke SH, Isidor B, Mercier S, Magnussen K, Zacher P, Hashim M, Pagnamenta AT, Race S, Srivastava S, Frazier Z, Maiwald R, Pergande M, Milani D, Rinelli M, Levy J, Krey I, Fontana P, Lonardo F, Riley S, Kretzer J, Rankin J, Reis LM, Semina EV, Reuter MS, Scherer SW, Iascone M, Weis D, Fagerberg CR, Brasch-Andersen C, Hansen LK, Kuechler A, Noble N, Gardham A, Tenney J, Rathore G, Beck-Woedl S, Haack TB, Pavlidou DC, Atallah I, Vodopiutz J, Janecke AR, Hsieh TC, Lesmann H, Klinkhammer H, Krawitz PM, Lemke JR, Jamra RA, Nieto M, Tümer Z, Platzer K. Oppermann H, et al. Eur J Hum Genet. 2023 Nov;31(11):1251-1260. doi: 10.1038/s41431-023-01445-2. Epub 2023 Aug 30. Eur J Hum Genet. 2023. PMID: 37644171 Free PMC article.
We analyze brain CUX1 expression and susceptibility to epilepsy in Cux1(+/-) mice. We describe 34 individuals, from which 30 were unrelated, with 26 different null and four missense variants. ...In Cux1(+/-) brains, the expression of Cux1 transcripts w …
We analyze brain CUX1 expression and susceptibility to epilepsy in Cux1(+/-) mice. We describe 34 individuals, from which 30 w …
CUX1, A Controversial Player in Tumor Development.
Liu N, Sun Q, Wan L, Wang X, Feng Y, Luo J, Wu H. Liu N, et al. Front Oncol. 2020 May 29;10:738. doi: 10.3389/fonc.2020.00738. eCollection 2020. Front Oncol. 2020. PMID: 32547943 Free PMC article. Review.
While loss of heterozygosity and/or mutations of CUX1 have been frequently detected in many types of cancers, genomic amplification, and overexpression of CUX1 have also been reported in cancer tissues and are correlated with higher tumor grade and poor prognosis. T …
While loss of heterozygosity and/or mutations of CUX1 have been frequently detected in many types of cancers, genomic amplification, …
The significance of CUX1 and chromosome 7 in myeloid malignancies.
Jotte MRM, McNerney ME. Jotte MRM, et al. Curr Opin Hematol. 2022 Mar 1;29(2):92-102. doi: 10.1097/MOH.0000000000000699. Curr Opin Hematol. 2022. PMID: 35084368 Free PMC article. Review.
PURPOSE OF REVIEW: Loss of chromosome 7 has long been associated with adverse-risk myeloid malignancy. In the last decade, CUX1 has been identified as a critical tumor suppressor gene (TSG) located within a commonly deleted segment of chromosome arm 7q. ...This review will …
PURPOSE OF REVIEW: Loss of chromosome 7 has long been associated with adverse-risk myeloid malignancy. In the last decade, CUX1 has b …
CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers.
Ramdzan ZM, Nepveu A. Ramdzan ZM, et al. Nat Rev Cancer. 2014 Oct;14(10):673-82. doi: 10.1038/nrc3805. Epub 2014 Sep 5. Nat Rev Cancer. 2014. PMID: 25190083 Review.
The accumulated evidence supports a model of haploinsufficiency whereby reduced CUX1 expression promotes tumour development. Paradoxically, increased CUX1 expression is associated with tumour progression, and ectopic CUX1 expression in transgenic mice increas …
The accumulated evidence supports a model of haploinsufficiency whereby reduced CUX1 expression promotes tumour development. Paradoxi …
CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases.
Hulea L, Nepveu A. Hulea L, et al. Gene. 2012 Apr 10;497(1):18-26. doi: 10.1016/j.gene.2012.01.039. Epub 2012 Jan 28. Gene. 2012. PMID: 22306263 Review.
CUX1 has also been implicated in the etiology of polycystic kidney diseases, both from a transgenic approach and the analysis of CUX1 activity in multiple mouse models of this disease. ...Overall, studies in various fields have allowed the development of several cel …
CUX1 has also been implicated in the etiology of polycystic kidney diseases, both from a transgenic approach and the analysis of C …
CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex.
Liu W, Kurkewich JL, Stoddart A, Khan S, Anandan D, Gaubil AN, Wolfgeher DJ, Jueng L, Kron SJ, McNerney ME. Liu W, et al. Cell Rep. 2024 May 28;43(5):114227. doi: 10.1016/j.celrep.2024.114227. Epub 2024 May 11. Cell Rep. 2024. PMID: 38735044 Free PMC article.
However, the mechanism by which CUX1 regulates gene expression and differentiation remains poorly understood, creating a barrier to understanding the tumor-suppressive functions of CUX1. ...CUX1 preferentially regulates lineage-specific enhancers, and CUX1 …
However, the mechanism by which CUX1 regulates gene expression and differentiation remains poorly understood, creating a barrier to u …
Consider CUX1 variants in children with a variation of sex development: a case report and review of the literature.
Tan L, Young SG, Sinclair AH, Hunter MF, Ayers KL. Tan L, et al. BMC Med Genomics. 2024 Aug 5;17(1):195. doi: 10.1186/s12920-024-01945-0. BMC Med Genomics. 2024. PMID: 39103808 Free PMC article. Review.
Individuals with variants in CUX1 have been described with a variety of co-morbidities including variations in sex development (VSD) although these features have not been closely documented. ...Further work is required to fully investigate the role and regulation of CUX …
Individuals with variants in CUX1 have been described with a variety of co-morbidities including variations in sex development (VSD) …
Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells.
An N, Khan S, Imgruet MK, Jueng L, Gurbuxani S, McNerney ME. An N, et al. Oncogene. 2023 Mar;42(12):881-893. doi: 10.1038/s41388-023-02612-x. Epub 2023 Feb 1. Oncogene. 2023. PMID: 36725889 Free PMC article.
-7/del(7q) is prevalent across subtypes of myeloid neoplasms. CUX1, located on 7q22, encodes a homeodomain-containing transcription factor, and, like -7/del(7q), CUX1 inactivating mutations independently carry a poor prognosis. As with loss of 7q, CUX1 mutati …
-7/del(7q) is prevalent across subtypes of myeloid neoplasms. CUX1, located on 7q22, encodes a homeodomain-containing transcription f …
Post-GWAS functional analysis identifies CUX1 as a regulator of p16(INK4a) and cellular senescence.
Jiang D, Sun W, Wu T, Zou M, Vasamsetti SB, Zhang X, Zhao Y, Phillippi JA, Sawalha AH, Tavakoli S, Dutta P, Florentin J, Chan SY, Tollison TS, Di Wu, Cui J, Huntress I, Peng X, Finkel T, Li G. Jiang D, et al. Nat Aging. 2022 Feb;2(2):140-154. doi: 10.1038/s43587-022-00177-0. Epub 2022 Feb 17. Nat Aging. 2022. PMID: 37117763 Free PMC article.
Endothelial CUX1 expression correlates with telomeric length and is induced by both DNA-damaging agents and oxidative stress. Moreover, induction of CUX1 expression triggers both replicative and stress-induced senescence via activation of p16(INK4a) expression. ...
Endothelial CUX1 expression correlates with telomeric length and is induced by both DNA-damaging agents and oxidative stress. Moreove …
CUX1-Transcriptional Master Regulator of Tumor Progression in Pancreatic Neuroendocrine Tumors.
Krug S, Weissbach J, Blank A, Perren A, Haybaeck J, Fendrich V, Rinke A, Gress TM, Rosendahl J, Michl P. Krug S, et al. Cancers (Basel). 2020 Jul 19;12(7):1957. doi: 10.3390/cancers12071957. Cancers (Basel). 2020. PMID: 32707646 Free PMC article.
To further assess the functional role of CUX1, expression profiling of DNA damage-, proliferation- and apoptosis-associated genes was performed in CUX1-overexpressing Bon-1 cells. ...In both groups, high CUX1 levels indicated a metastatic phenotype. Functiona …
To further assess the functional role of CUX1, expression profiling of DNA damage-, proliferation- and apoptosis-associated genes was …
498 results