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Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan dihydrochloride).
Midgley I, Fitzpatrick K, Taylor LM, Houchen TL, Henderson SJ, Wright SJ, Cybulski ZR, John BA, McBurney A, Boykin DW, Trendler KL. Midgley I, et al. Among authors: cybulski zr. Drug Metab Dispos. 2007 Jun;35(6):955-67. doi: 10.1124/dmd.106.013391. Epub 2007 Mar 14. Drug Metab Dispos. 2007. PMID: 17360833