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Year Number of Results
2015 2
2016 2
2017 5
2018 2
2019 2
2020 1
2021 0
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13 results
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Pathogenic variants that alter protein code often disrupt splicing.
Soemedi R, Cygan KJ, Rhine CL, Wang J, Bulacan C, Yang J, Bayrak-Toydemir P, McDonald J, Fairbrother WG. Soemedi R, et al. Among authors: cygan kj. Nat Genet. 2017 Jun;49(6):848-855. doi: 10.1038/ng.3837. Epub 2017 Apr 17. Nat Genet. 2017. PMID: 28416821 Free PMC article.
The effects of structure on pre-mRNA processing and stability.
Soemedi R, Cygan KJ, Rhine CL, Glidden DT, Taggart AJ, Lin CL, Fredericks AM, Fairbrother WG. Soemedi R, et al. Among authors: cygan kj. Methods. 2017 Aug 1;125:36-44. doi: 10.1016/j.ymeth.2017.06.001. Epub 2017 Jun 6. Methods. 2017. PMID: 28595983 Free PMC article. Review.
RNA-Binding Proteins: Splicing Factors and Disease.
Fredericks AM, Cygan KJ, Brown BA, Fairbrother WG. Fredericks AM, et al. Among authors: cygan kj. Biomolecules. 2015 May 13;5(2):893-909. doi: 10.3390/biom5020893. Biomolecules. 2015. PMID: 25985083 Free PMC article. Review.
Hereditary cancer genes are highly susceptible to splicing mutations.
Rhine CL, Cygan KJ, Soemedi R, Maguire S, Murray MF, Monaghan SF, Fairbrother WG. Rhine CL, et al. Among authors: cygan kj. PLoS Genet. 2018 Mar 5;14(3):e1007231. doi: 10.1371/journal.pgen.1007231. eCollection 2018 Mar. PLoS Genet. 2018. PMID: 29505604 Free PMC article.
The importance of p53 pathway genetics in inherited and somatic cancer genomes.
Stracquadanio G, Wang X, Wallace MD, Grawenda AM, Zhang P, Hewitt J, Zeron-Medina J, Castro-Giner F, Tomlinson IP, Goding CR, Cygan KJ, Fairbrother WG, Thomas LF, Sætrom P, Gemignani F, Landi S, Schuster-Böckler B, Bell DA, Bond GL. Stracquadanio G, et al. Among authors: cygan kj. Nat Rev Cancer. 2016 Apr;16(4):251-65. doi: 10.1038/nrc.2016.15. Nat Rev Cancer. 2016. PMID: 27009395 Free PMC article. Review.
RNA structure replaces the need for U2AF2 in splicing.
Lin CL, Taggart AJ, Lim KH, Cygan KJ, Ferraris L, Creton R, Huang YT, Fairbrother WG. Lin CL, et al. Among authors: cygan kj. Genome Res. 2016 Jan;26(1):12-23. doi: 10.1101/gr.181008.114. Epub 2015 Nov 13. Genome Res. 2016. PMID: 26566657 Free PMC article.
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