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7,431 results

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Page 1
CYP1A2 expression rather than genotype is associated with olanzapine concentration in psychiatric patients.
Fekete F, Menus Á, Tóth K, Kiss ÁF, Minus A, Sirok D, Belič A, Póti Á, Csukly G, Monostory K. Fekete F, et al. Sci Rep. 2023 Oct 28;13(1):18507. doi: 10.1038/s41598-023-45752-6. Sci Rep. 2023. PMID: 37898643 Free PMC article.
The present work focused on the impact of CYP1A2 and CYP2D6 genetic polymorphisms as well as of CYP1A2 metabolizing capacity influenced by non-genetic factors (sex, age, smoking) on olanzapine blood concentration in patients with psychiatric disorders (N = 139). CYP …
The present work focused on the impact of CYP1A2 and CYP2D6 genetic polymorphisms as well as of CYP1A2 metabolizing capacity i …
CYP1A2 genotype and acute ergogenic effects of caffeine intake on exercise performance: a systematic review.
Grgic J, Pickering C, Del Coso J, Schoenfeld BJ, Mikulic P. Grgic J, et al. Eur J Nutr. 2021 Apr;60(3):1181-1195. doi: 10.1007/s00394-020-02427-6. Epub 2020 Nov 2. Eur J Nutr. 2021. PMID: 33137206 Review.
PURPOSE: To systematically review studies that examined the influence of the CYP1A2 -163C>A polymorphism on the ergogenic effects of caffeine and to discuss some of the reasons for the discrepancies in findings between the studies. ...For high-intensity exercise, two st …
PURPOSE: To systematically review studies that examined the influence of the CYP1A2 -163C>A polymorphism on the ergogenic effects …
Metabolism and Mechanism of Human Cytochrome P450 Enzyme 1A2.
Guo J, Zhu X, Badawy S, Ihsan A, Liu Z, Xie C, Wang X. Guo J, et al. Curr Drug Metab. 2021;22(1):40-49. doi: 10.2174/1389200221999210101233135. Curr Drug Metab. 2021. PMID: 33397254 Review.
Human cytochrome P450 enzyme 1A2 (CYP1A2) is one of the most important cytochrome P450 (CYP) enzymes in the liver, accounting for 13% to 15% of hepatic CYP enzymes. ...Here, we review the drugs metabolised by CYP1A2, the metabolic mechanism of CYP1A …
Human cytochrome P450 enzyme 1A2 (CYP1A2) is one of the most important cytochrome P450 (CYP) enzymes in the liver, acco …
CYP1A2 and tobacco interaction: a major pharmacokinetic challenge during smoking cessation.
Barrangou-Poueys-Darlas M, Guerlais M, Laforgue EJ, Bellouard R, Istvan M, Chauvin P, Guillet JY, Jolliet P, Gregoire M, Victorri-Vigneau C. Barrangou-Poueys-Darlas M, et al. Drug Metab Rev. 2021 Feb;53(1):30-44. doi: 10.1080/03602532.2020.1859528. Epub 2021 Jan 4. Drug Metab Rev. 2021. PMID: 33325257
Abrupt smoking cessation is common in cases of emergency hospitalization and restrictions of movement. Tobacco is a known cytochrome P450 1A2 (CYP1A2) inducer, its consumption and withdrawal can lead to major pharmacokinetic drug interactions. ...The objective of ou …
Abrupt smoking cessation is common in cases of emergency hospitalization and restrictions of movement. Tobacco is a known cytochrome …
Rapid genotyping for relevant CYP1A2 alleles by pyrosequencing.
Skarke C, Kirchhof A, Geisslinger G, Lötsch J. Skarke C, et al. Eur J Clin Pharmacol. 2005 Dec;61(12):887-92. doi: 10.1007/s00228-005-0029-3. Epub 2005 Nov 24. Eur J Clin Pharmacol. 2005. PMID: 16307269 Review.
OBJECTIVE: To develop a rapid and reliable screening method for identifying the relevant cytochrome P450 (CYP) 1A2 alleles CYP1A2*1D (-2467Tdel), *1F (-163A>C), and *1K (-739T>G, -729C>T, -163A>C) that are in linkage disequilibrium with the functionally …
OBJECTIVE: To develop a rapid and reliable screening method for identifying the relevant cytochrome P450 (CYP) 1A2 alleles CYP1A2 …
Assessment of CYP1A2 activity in clinical practice: why, how, and when?
Faber MS, Jetter A, Fuhr U. Faber MS, et al. Basic Clin Pharmacol Toxicol. 2005 Sep;97(3):125-34. doi: 10.1111/j.1742-7843.2005.pto_973160.x. Basic Clin Pharmacol Toxicol. 2005. PMID: 16128905 Free article. Review.
The cytochrome P450 enzyme CYP1A2 mediates the rate-limiting step in the metabolism of many drugs including theophylline, clozapine, and tacrine as well as in the bioactivation of procarcinogens. ...CYP1A2 is almost exclusively expressed in the liver. Since l …
The cytochrome P450 enzyme CYP1A2 mediates the rate-limiting step in the metabolism of many drugs including theophylline, cloz …
Considering CYP1A2 phenotype and genotype for optimizing the dose of olanzapine in the management of schizophrenia.
Perera V, Gross AS, Polasek TM, Qin Y, Rao G, Forrest A, Xu J, McLachlan AJ. Perera V, et al. Expert Opin Drug Metab Toxicol. 2013 Sep;9(9):1115-37. doi: 10.1517/17425255.2013.795540. Epub 2013 May 4. Expert Opin Drug Metab Toxicol. 2013. PMID: 23641727 Review.
AREAS COVERED: The current review investigates variability in response to olanzapine with a specific focus on the common intrinsic and extrinsic factors that influence both olanzapine and CYP1A2 activity. Furthermore, the authors discuss the utilization of phenotyping and …
AREAS COVERED: The current review investigates variability in response to olanzapine with a specific focus on the common intrinsic and extri …
Habitual coffee consumption and risk of dementia in older persons: modulation by CYP1A2 polymorphism.
Lefèvre-Arbogast S, Helmer C, Berr C, Debette S, Samieri C. Lefèvre-Arbogast S, et al. Eur J Epidemiol. 2024 Jan;39(1):81-86. doi: 10.1007/s10654-023-01060-x. Epub 2023 Oct 31. Eur J Epidemiol. 2024. PMID: 37906419
Results were similar when studying AD and another CYP1A2 candidate polymorphism (rs2472304), but no interaction was found with CYP1A2 rs2472297 or rs2470893. In this cohort, a linear association of coffee intake to lower dementia risk was apparent only among carrier …
Results were similar when studying AD and another CYP1A2 candidate polymorphism (rs2472304), but no interaction was found with CYP …
Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms.
Gunes A, Dahl ML. Gunes A, et al. Pharmacogenomics. 2008 May;9(5):625-37. doi: 10.2217/14622416.9.5.625. Pharmacogenomics. 2008. PMID: 18466106 Review.
The current knowledge regarding factors influencing the activity of CYP1A2 is summarized in this review. Substrates, inhibitors and inducers of CYP1A2 activity, as well as phenotyping probes, are discussed. The functional significance and clinical importance of C …
The current knowledge regarding factors influencing the activity of CYP1A2 is summarized in this review. Substrates, inhibitors and i …
7,431 results