Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2006 1
2008 1
2009 1
2010 2
2012 1
2013 2
2014 1
2015 1
2016 2
2017 2
2018 2
2019 4
2020 2
2021 1
2022 2
2024 2
2026 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

25 results

Results by year

Filters applied: . Clear all
Page 1
The expression of intestinal Cyp2c55 is regulated by the microbiota and inflammation.
Hilman A, Sato T, Wijatniko BD, Fujimura S, Nakamura K, Miura H, Iwatsuki K, Inoue R, Suzuki T. Hilman A, et al. FASEB J. 2024 Oct 31;38(20):e70117. doi: 10.1096/fj.202401807R. FASEB J. 2024. PMID: 39432326 Free PMC article.
While administration of an agonist of the pregnane X receptor (PXR) increased the Cyp2c55 expression in mouse colonoids, inflammatory cytokines decreased it. In conclusion, Cyp2c55 was highly expressed in the colonic epithelial cells of mice in a microbiota-dependen …
While administration of an agonist of the pregnane X receptor (PXR) increased the Cyp2c55 expression in mouse colonoids, inflammatory …
Dietary Squalene Induces Cytochromes Cyp2b10 and Cyp2c55 Independently of Sex, Dose, and Diet in Several Mouse Models.
Gabás-Rivera C, Jurado-Ruiz E, Sánchez-Ortiz A, Romanos E, Martínez-Beamonte R, Navarro MA, Surra JC, Arnal C, Rodríguez-Yoldi MJ, Andrés-Lacueva C, Osada J. Gabás-Rivera C, et al. Mol Nutr Food Res. 2020 Oct;64(20):e2000354. doi: 10.1002/mnfr.202000354. Epub 2020 Sep 28. Mol Nutr Food Res. 2020. PMID: 32918392
Squalene supplementation increases its hepatic content without differences among sexes and hormonal status. The Cyp2b10 and Cyp2c55 gene expressions are significantly up-regulated by the squalene intake in all models, with independence of sex, sexual hormones, dietary fat …
Squalene supplementation increases its hepatic content without differences among sexes and hormonal status. The Cyp2b10 and Cyp2c55 g …
The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver.
Konno Y, Kamino H, Moore R, Lih F, Tomer KB, Zeldin DC, Goldstein JA, Negishi M. Konno Y, et al. Drug Metab Dispos. 2010 Jul;38(7):1177-82. doi: 10.1124/dmd.110.032334. Epub 2010 Apr 6. Drug Metab Dispos. 2010. PMID: 20371638 Free PMC article.
We have now found that CYP2C55 is induced by phenobarbital (PB) and pregnenolone 16alpha-carbonitrile (PCN) in both mouse kidney and liver. ...Cell-based promoter analysis and gel shift assays identified the DNA sequence (-1679)TGAACCCAGTTGAACT(-1664) as a DR4 motif that r …
We have now found that CYP2C55 is induced by phenobarbital (PB) and pregnenolone 16alpha-carbonitrile (PCN) in both mouse kidney and …
Transcriptomic analysis reveals the mechanism of sulfasalazine-induced liver injury in mice.
Li YC, Shen JD, Lu SF, Zhu LL, Wang BY, Bai M, Xu EP. Li YC, et al. Toxicol Lett. 2020 Mar 15;321:12-20. doi: 10.1016/j.toxlet.2019.12.011. Epub 2019 Dec 9. Toxicol Lett. 2020. PMID: 31830553
Moreover, the mRNA levels of egfr and cyp2c55 exhibited a dose-dependent changes in SASP groups. Western blotting verified that the changes of protein levels of EGFR and CYP2C55 were consistent with mRNA levels. Considering that egfr has the highest score in PPI deg …
Moreover, the mRNA levels of egfr and cyp2c55 exhibited a dose-dependent changes in SASP groups. Western blotting verified that the c …
Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.
Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC. Wang H, et al. Mol Pharmacol. 2004 May;65(5):1148-58. doi: 10.1124/mol.65.5.1148. Mol Pharmacol. 2004. PMID: 15102943
Northern blotting and reverse transcription-polymerase chain reaction analysis reveal that CYP2C50 transcripts are abundant in liver and heart; CYP2C54 transcripts are present in liver, kidney, and stomach; and CYP2C55 transcripts are abundant in liver, colon, and kidney. …
Northern blotting and reverse transcription-polymerase chain reaction analysis reveal that CYP2C50 transcripts are abundant in liver and hea …
Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver.
van Waterschoot RA, Rooswinkel RW, Wagenaar E, van der Kruijssen CM, van Herwaarden AE, Schinkel AH. van Waterschoot RA, et al. FASEB J. 2009 Jan;23(1):224-31. doi: 10.1096/fj.08-114876. Epub 2008 Sep 15. FASEB J. 2009. PMID: 18794335
CYP3A4 is an important xenobiotic metabolizing enzyme. We previously found that CYP2C55 is highly up-regulated in Cyp3a(-/-) mice. Here, we have further investigated the mechanism of regulation of CYP2C55 and other detoxifying systems in Cyp3a(-/-) mice. Induction s …
CYP3A4 is an important xenobiotic metabolizing enzyme. We previously found that CYP2C55 is highly up-regulated in Cyp3a(-/-) mice. He …
Characterization of the Tissue Distribution of the Mouse Cyp2c Subfamily by Quantitative PCR Analysis.
Graves JP, Gruzdev A, Bradbury JA, DeGraff LM, Edin ML, Zeldin DC. Graves JP, et al. Drug Metab Dispos. 2017 Jul;45(7):807-816. doi: 10.1124/dmd.117.075697. Epub 2017 Apr 27. Drug Metab Dispos. 2017. PMID: 28450579 Free PMC article.
We report new methods and results for the quantitative polymerase reaction (qPCR) analysis for the 15 members of the mouse Cyp2c subfamily (Cyp2c29, Cyp2c37, Cyp2c38, Cyp2c39, Cyp2c40, Cyp2c44, Cyp2c50, Cyp2c54, Cyp2c55, Cyp2c65, Cyp2c66, Cyp2c67, Cyp2c68, Cyp2c69, and Cyp …
We report new methods and results for the quantitative polymerase reaction (qPCR) analysis for the 15 members of the mouse Cyp2c subfamily ( …
Yes-Associated Protein Is Crucial for Constitutive Androstane Receptor-Driven Hepatocyte Proliferation But Not for Induction of Drug Metabolism Genes in Mice.
Bhushan B, Molina L, Koral K, Stoops JW, Mars WM, Banerjee S, Orr A, Paranjpe S, Monga SP, Locker J, Michalopoulos GK. Bhushan B, et al. Hepatology. 2021 May;73(5):2005-2022. doi: 10.1002/hep.31521. Hepatology. 2021. PMID: 32794202 Free PMC article.
Yap deletion did not decrease protein expression of CAR or CAR-driven induction of drug metabolism genes (including cytochrome P450 [Cyp] 2b10, Cyp2c55, and UDP-glucuronosyltransferase 1a1 [Ugt1a1]). However, Yap deletion substantially reduced TCPOBOP-induced hepatocyte pr …
Yap deletion did not decrease protein expression of CAR or CAR-driven induction of drug metabolism genes (including cytochrome P450 [Cyp] 2b …
Investigating the Mechanisms of 15-PGDH Inhibitor SW033291 in Improving Type 2 Diabetes Mellitus: Insights from Metabolomics and Transcriptomics.
Huang Y, Liang M, Liao Y, Ji Z, Lin W, Pu X, Wang L, Wang W. Huang Y, et al. Metabolites. 2024 Sep 20;14(9):509. doi: 10.3390/metabo14090509. Metabolites. 2024. PMID: 39330516 Free PMC article.
Furthermore, integrated transcriptomic and metabolomic analyses suggested that key genes and metabolites such as Cyp2c55, Cyp3a11, Cyp21a1, Myc, Gstm1, Gstm3, 9,10-dihydroxyoctadecenoic acid, 11-dehydrocorticosterone, and 12,13-dihydroxy-9Z-octadecenoic acid played crucial …
Furthermore, integrated transcriptomic and metabolomic analyses suggested that key genes and metabolites such as Cyp2c55, Cyp3a11, Cy …
Lactobacillus plantarum AR113 alleviates Western Diet-Induced colitis and liver injury via bidirectional modulation of the Intestinal-Hepatic FXR signaling axis.
Shao J, Zhao D, Xia Y, Wang G, Song X, Yang Y, Xiong Z, Ai L. Shao J, et al. J Adv Res. 2026 Feb 21:S2090-1232(26)00180-3. doi: 10.1016/j.jare.2026.02.048. Online ahead of print. J Adv Res. 2026. PMID: 41730412 Free article.
RESULTS: AR113 treatment significantly reduced serum and fecal DCA levels, upregulated the expression of ZO-1 and occludin (by 19% and 124%, respectively, compared to the PBS group), enhanced the expression of key bile acid detoxification genes (Cyp3a13, Cyp2c55, and Sult1 …
RESULTS: AR113 treatment significantly reduced serum and fecal DCA levels, upregulated the expression of ZO-1 and occludin (by 19% and 124%, …
25 results