Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2000 1
2002 1
2003 1
2006 2
2007 2
2009 1
2012 1
2013 1
2015 3
2016 2
2017 3
2018 1
2020 1
2024 3
2025 1
2026 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

22 results

Results by year

Filters applied: . Clear all
Page 1
A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation.
Yang HH, Duan JX, Liu SK, Xiong JB, Guan XX, Zhong WJ, Sun CC, Zhang CY, Luo XQ, Zhang YF, Chen P, Hammock BD, Hwang SH, Jiang JX, Zhou Y, Guan CX. Yang HH, et al. Theranostics. 2020 Mar 26;10(11):4749-4761. doi: 10.7150/thno.43108. eCollection 2020. Theranostics. 2020. PMID: 32308747 Free PMC article.
Results: Dysregulation of CYPs/COX-2 metabolism of ARA occurred in the lungs and in primary macrophages under the LPS challenge. Decrease mRNA expression of Cyp2j9, Cyp2j6, and Cyp2j5 was observed, which metabolize ARA into epoxyeicosatrienoic acids (EETs). ...
Results: Dysregulation of CYPs/COX-2 metabolism of ARA occurred in the lungs and in primary macrophages under the LPS challenge. Decrease mR …
Molecular cloning and characterization of mouse CYP2J6, an unstable cytochrome P450 isoform.
Ma J, Bradbury JA, King L, Maronpot R, Davis LS, Breyer MD, Zeldin DC. Ma J, et al. Biochem Pharmacol. 2002 Nov 15;64(10):1447-60. doi: 10.1016/s0006-2952(02)01393-x. Biochem Pharmacol. 2002. PMID: 12417258
In situ hybridization revealed that CYP2J6 mRNAs are present in luminal epithelial cells of the gastrointestinal mucosa. The CYP2J6 cDNA was expressed in Sf9 cells using baculovirus. ...Sf9 cells, which express both CYP2J6 and NADPH-P450 oxidoreductase, metab …
In situ hybridization revealed that CYP2J6 mRNAs are present in luminal epithelial cells of the gastrointestinal mucosa. The CYP2J …
Identification and expression of cytochrome P450 genes in the Chinese giant salamander Andrias davidianus.
Hu Q, Xiao H, Tian H, Meng Y. Hu Q, et al. Theriogenology. 2017 Jun;95:62-68. doi: 10.1016/j.theriogenology.2017.03.001. Epub 2017 Mar 7. Theriogenology. 2017. PMID: 28460681
Cyp2k1, cyp11b1, and cyp2j6 expression were increased, while cyp26a, cyp2c20, cyp4b genes were decreased with aromatase inhibition. In ovary, cyp26a and cyp2c20 expression were significantly reduced; whereas cyp2k1, cyp2j6, and cyp2k4 expression were significantly e …
Cyp2k1, cyp11b1, and cyp2j6 expression were increased, while cyp26a, cyp2c20, cyp4b genes were decreased with aromatase inhibition. I …
Vitamin D metabolism is altered during aging alone or combined with obesity in male mice.
Bournot L, Payet T, Marcotorchino J, Awada M, Rouquet T, Breniere T, Couturier C, Astier J, Halimi C, Reboul E, Sicard F, Mounien L, Roux J, Bariohay B, Landrier JF. Bournot L, et al. Biofactors. 2024 Sep-Oct;50(5):957-966. doi: 10.1002/biof.2047. Epub 2024 Feb 24. Biofactors. 2024. PMID: 38401051
The mRNA expression of Cyp27a1, Cyp3a11, and Cyp2j6 were decreased in the liver during aging. Together, these regulations could explain the reduced 25-hydroxylation. Interestingly, the lack of cumulative reduction of 25(OH)D in aged and obese mice could be related to the s …
The mRNA expression of Cyp27a1, Cyp3a11, and Cyp2j6 were decreased in the liver during aging. Together, these regulations could expla …
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.
Sisignano M, Angioni C, Park CK, Meyer Dos Santos S, Jordan H, Kuzikov M, Liu D, Zinn S, Hohman SW, Schreiber Y, Zimmer B, Schmidt M, Lu R, Suo J, Zhang DD, Schäfer SM, Hofmann M, Yekkirala AS, de Bruin N, Parnham MJ, Woolf CJ, Ji RR, Scholich K, Geisslinger G. Sisignano M, et al. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12544-12549. doi: 10.1073/pnas.1613246113. Epub 2016 Oct 17. Proc Natl Acad Sci U S A. 2016. PMID: 27791151 Free PMC article.
Here, we report increased expression of the cytochrome-P(450)-epoxygenase CYP2J6 and increased concentrations of its linoleic acid metabolite 9,10-EpOME (9,10-epoxy-12Z-octadecenoic acid) in dorsal root ganglia (DRGs) of paclitaxel-treated mice as a model of CIPNP. ...In a …
Here, we report increased expression of the cytochrome-P(450)-epoxygenase CYP2J6 and increased concentrations of its linoleic acid me …
Coordination regulation of enhanced performance reveals the tolerance mechanism of Chlamys farreri to azaspiracid toxicity.
Wu H, Zhang Q, Dong C, Zheng G, Tan Z, Gu H. Wu H, et al. J Hazard Mater. 2024 Sep 5;476:135247. doi: 10.1016/j.jhazmat.2024.135247. Epub 2024 Jul 17. J Hazard Mater. 2024. PMID: 39029196
DEGs increased over time, with key genes CYP2J6 and GPX6 contributing to AZA metabolism. These transcriptome and metabolic results identify the regulation of energy metabolism pathways, including inhibition of the TCA cycle and activation of carbohydrates, amino acids, and …
DEGs increased over time, with key genes CYP2J6 and GPX6 contributing to AZA metabolism. These transcriptome and metabolic results id …
Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.
Graves JP, Gruzdev A, Bradbury JA, DeGraff LM, Li H, House JS, Hoopes SL, Edin ML, Zeldin DC. Graves JP, et al. Drug Metab Dispos. 2015 Aug;43(8):1169-80. doi: 10.1124/dmd.115.064139. Epub 2015 May 20. Drug Metab Dispos. 2015. PMID: 25994032 Free PMC article.
Cyp2j5 and Cyp2j13 were highly expressed in male kidneys, and Cyp2j11 was highly expressed in both male and female kidneys. Cyp2j6 was expressed in multiple tissues, with the highest expression in the small intestine and duodenum. ...Both qPCR methods detected similar supp …
Cyp2j5 and Cyp2j13 were highly expressed in male kidneys, and Cyp2j11 was highly expressed in both male and female kidneys. Cyp2j6 wa …
Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides.
Wang W, Yang J, Qi W, Yang H, Wang C, Tan B, Hammock BD, Park Y, Kim D, Zhang G. Wang W, et al. Obesity (Silver Spring). 2017 Jan;25(1):132-140. doi: 10.1002/oby.21692. Epub 2016 Nov 28. Obesity (Silver Spring). 2017. PMID: 27891824 Free PMC article.
Consistent with the reduced levels of fatty acid epoxides, the gene expression of several CYP epoxygenases, including Cyp2j5, Cyp2j6, and Cyp2c44, was significantly reduced in adipose tissues of high-fat diet-fed mice. ...
Consistent with the reduced levels of fatty acid epoxides, the gene expression of several CYP epoxygenases, including Cyp2j5, Cyp2j6, …
Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4.
Ma J, Ramachandran S, Fiedorek FT Jr, Zeldin DC. Ma J, et al. Genomics. 1998 Apr 1;49(1):152-5. doi: 10.1006/geno.1998.5235. Genomics. 1998. PMID: 9570962
We have identified sequence variants in the 3' untranslated regions of two mouse Cyp2j genes (Cyp2j5 and Cyp2j6) and used a PCR-based oligonucleotide hybridization assay to map both genes to the central region of chromosome 4 distal to the Jun oncogene. ...
We have identified sequence variants in the 3' untranslated regions of two mouse Cyp2j genes (Cyp2j5 and Cyp2j6) and used a PCR-based …
Cytochrome P450 (CYP) epoxygenases as potential targets in the management of impaired diabetic wound healing.
Zhao H, Chen J, Chai J, Zhang Y, Yu C, Pan Z, Gao P, Zong C, Guan Q, Fu Y, Liu Y. Zhao H, et al. Lab Invest. 2017 Jul;97(7):782-791. doi: 10.1038/labinvest.2017.21. Epub 2017 Mar 20. Lab Invest. 2017. PMID: 28319086 Free article.
Compared with C57BL/6 mice, the mRNA and protein expression of CYP2C65 and CYP2J6 in the granulation tissues in ob/ob mice were significantly reduced. 11,12-EET treatment significantly improved wound healing in ob/ob mice, whereas 14,15-EEZE, an EET antagonist, showed the …
Compared with C57BL/6 mice, the mRNA and protein expression of CYP2C65 and CYP2J6 in the granulation tissues in ob/ob mice were signi …
22 results