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Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury.
Norman BH, Fisher MJ, Schiffler MA, Kuklish SL, Hughes NE, Czeskis BA, Cassidy KC, Abraham TL, Alberts JJ, Luffer-Atlas D. Norman BH, et al. Among authors: czeskis ba. J Med Chem. 2018 Mar 8;61(5):2041-2051. doi: 10.1021/acs.jmedchem.7b01806. Epub 2018 Feb 15. J Med Chem. 2018. PMID: 29425457
Absolute bioavailability of evacetrapib in healthy subjects determined by simultaneous administration of oral evacetrapib and intravenous [(13) C8 ]-evacetrapib as a tracer.
Cannady EA, Aburub A, Ward C, Hinds C, Czeskis B, Ruterbories K, Suico JG, Royalty J, Ortega D, Pack BW, Begum SL, Annes WF, Lin Q, Small DS. Cannady EA, et al. Among authors: czeskis b. J Labelled Comp Radiopharm. 2016 May 30;59(6):238-44. doi: 10.1002/jlcr.3358. Epub 2015 Dec 7. J Labelled Comp Radiopharm. 2016. PMID: 26639670 Free PMC article. Clinical Trial.