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Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer.
Leidner R, Sanjuan Silva N, Huang H, Sprott D, Zheng C, Shih YP, Leung A, Payne R, Sutcliffe K, Cramer J, Rosenberg SA, Fox BA, Urba WJ, Tran E. Leidner R, et al. N Engl J Med. 2022 Jun 2;386(22):2112-2119. doi: 10.1056/NEJMoa2119662. N Engl J Med. 2022. PMID: 35648703 Free PMC article.
A patient with progressive metastatic pancreatic cancer was treated with a single infusion of 16.210(9) autologous T cells that had been genetically engineered to clonally express two allogeneic HLA-C*08:02-restricted T-cell receptors (TCRs) targeting mutant KRAS G1 …
A patient with progressive metastatic pancreatic cancer was treated with a single infusion of 16.210(9) autologous T cells that had b …
HeartBioPortal.
Khomtchouk BB, Vand KA, Koehler WC, Tran DT, Middlebrook K, Sudhakaran S, Nelson CS, Gozani O, Assimes TL. Khomtchouk BB, et al. Circ Genom Precis Med. 2019 Apr;12(4):e002426. doi: 10.1161/CIRCGEN.118.002426. Epub 2019 Apr 16. Circ Genom Precis Med. 2019. PMID: 31294639 Free PMC article. No abstract available.
APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology.
Tran TTT, Corsini S, Kellingray L, Hegarty C, Le Gall G, Narbad A, Müller M, Tejera N, O'Toole PW, Minihane AM, Vauzour D. Tran TTT, et al. FASEB J. 2019 Jul;33(7):8221-8231. doi: 10.1096/fj.201900071R. Epub 2019 Apr 8. FASEB J. 2019. PMID: 30958695 Free PMC article. Clinical Trial.
This suggests that the gut microbiome is worth further investigation as a potential target to mitigate the deleterious impact of the APOE4 allele on cognitive decline and the prevention of AD.-Tran, T. T. T., Corsini, S., Kellingray, L., Hegarty, C., L …
This suggests that the gut microbiome is worth further investigation as a potential target to mitigate the deleterious impact of the APOE4 a …
A lineage CLOUD for neoblasts.
Tran TA, Gentile L. Tran TA, et al. Semin Cell Dev Biol. 2019 Mar;87:22-29. doi: 10.1016/j.semcdb.2018.04.012. Epub 2018 May 10. Semin Cell Dev Biol. 2019. PMID: 29727726 Review.
1,938 results