Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial.
Gonzales MM, Garbarino VR, Kautz TF, Palavicini JP, Lopez-Cruzan M, Dehkordi SK, Mathews JJ, Zare H, Xu P, Zhang B, Franklin C, Habes M, Craft S, Petersen RC, Tchkonia T, Kirkland JL, Salardini A, Seshadri S, Musi N, Orr ME.
Gonzales MM, et al.
Nat Med. 2023 Oct;29(10):2481-2488. doi: 10.1038/s41591-023-02543-w. Epub 2023 Sep 7.
Nat Med. 2023.
PMID: 37679434
Free PMC article.
Clinical Trial.
Five participants (mean age = 76 + 5 years; 40% female) completed the 12-week pilot study. D and Q levels in blood increased in all participants (12.7-73.5 ng ml(-1) for D and 3.29-26.3 ng ml(-1) for Q). In cerebrospinal fluid (CSF), D levels were detected in …
Five participants (mean age = 76 + 5 years; 40% female) completed the 12-week pilot study. D and Q levels in blood increased in all p …