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Page 1
Mechanism of D-Cycloserine Inhibition of D-Amino Acid Transaminase from Haliscomenobacter hydrossis.
Bakunova AK, Matyuta IO, Nikolaeva AY, Boyko KM, Popov VO, Bezsudnova EY. Bakunova AK, et al. Biochemistry (Mosc). 2023 May;88(5):687-697. doi: 10.1134/S0006297923050115. Biochemistry (Mosc). 2023. PMID: 37331714
The aim of this work was to study the mechanism of D-cycloserine inhibition of the PLP-dependent D-amino acid transaminase from Haliscomenobacter hydrossis. ...The obtained results confirm reversibility of the inhibition by D-cycloserine and interconversion o …
The aim of this work was to study the mechanism of D-cycloserine inhibition of the PLP-dependent D-amino acid transaminase fro …
Regioselective CF(2) functionalization of Sc(3)N@D(3h)(5)-C(78).
Pykhova AD, Semivrazhskaya OO, Samoylova NA, Popov AA, Ioffe IN, Goryunkov AA. Pykhova AD, et al. Dalton Trans. 2022 Jan 17;51(3):1182-1190. doi: 10.1039/d1dt04031f. Dalton Trans. 2022. PMID: 34951436
Sc(3)N@C(78) appears to be considerably more reactive toward CF(2) addition than Sc(3)N@C(80) and somewhat more reactive than C(60). Even though the less symmetric D(3h)(5)-C(78) carbon cage offers far broader opportunities for isomerism than I(h)-C(80), CF(2) addition to …
Sc(3)N@C(78) appears to be considerably more reactive toward CF(2) addition than Sc(3)N@C(80) and somewhat more reactive than C(60). Even th …
Mechanistic aspects of the transamination reactions catalyzed by D-amino acid transaminase from Haliscomenobacter hydrossis.
Bakunova AK, Kostyukov AA, Kuzmin VA, Popov VO, Bezsudnova EY. Bakunova AK, et al. Biochim Biophys Acta Proteins Proteom. 2023 Feb 1;1871(2):140886. doi: 10.1016/j.bbapap.2022.140886. Epub 2022 Dec 7. Biochim Biophys Acta Proteins Proteom. 2023. PMID: 36496204
In this work, the pre-steady-state kinetics of the half-reactions of DAAT from Haliscomenobacter hydrossis with D-glutamate, D-alanine, D-leucine, and D-phenylalanine was examined at two wavelengths, 416 and 330 nm, using a stopped-flow technique. Mono …
In this work, the pre-steady-state kinetics of the half-reactions of DAAT from Haliscomenobacter hydrossis with D-glutamate, D …
To the Understanding of Catalysis by D-Amino Acid Transaminases: A Case Study of the Enzyme from Aminobacterium colombiense.
Shilova SA, Khrenova MG, Matyuta IO, Nikolaeva AY, Rakitina TV, Klyachko NL, Minyaev ME, Boyko KM, Popov VO, Bezsudnova EY. Shilova SA, et al. Molecules. 2023 Feb 23;28(5):2109. doi: 10.3390/molecules28052109. Molecules. 2023. PMID: 36903355 Free PMC article.
Pyridoxal-5'-phosphate (PLP)-dependent transaminases are highly efficient biocatalysts for stereoselective amination. D-amino acid transaminases can catalyze stereoselective transamination producing optically pure D-amino acids. ...We study the enzyme using kinetic …
Pyridoxal-5'-phosphate (PLP)-dependent transaminases are highly efficient biocatalysts for stereoselective amination. D-amino acid tr …
Serum Levels of Vitamin D in Patients with Multiple Myeloma.
Graklanov V, Popov V, Raycheva R. Graklanov V, et al. Folia Med (Plovdiv). 2020 Dec 31;62(4):730-735. doi: 10.3897/folmed.62.e50321. Folia Med (Plovdiv). 2020. PMID: 33415920
AIM: investigate the serum levels of vitamin D in newly diagnosed patients with multiple myeloma. PATIENTS AND METHODS: In this study we measured the serum levels of vitamin D in 37 patients (19 women, 18 men) at a median age of 68 years and a diagnosis of MM accord …
AIM: investigate the serum levels of vitamin D in newly diagnosed patients with multiple myeloma. PATIENTS AND METHODS: In this study …
Expanded Substrate Specificity in D-Amino Acid Transaminases: A Case Study of Transaminase from Blastococcus saxobsidens.
Shilova SA, Matyuta IO, Petrova ES, Nikolaeva AY, Rakitina TV, Minyaev ME, Boyko KM, Popov VO, Bezsudnova EY. Shilova SA, et al. Int J Mol Sci. 2023 Nov 10;24(22):16194. doi: 10.3390/ijms242216194. Int J Mol Sci. 2023. PMID: 38003383 Free PMC article.
Here, we analyze the structure-function relationships in a non-canonical D-amino acid transaminase from Blastococcus saxobsidens, which is active towards D-amino acids and primary (R)-amines. ...
Here, we analyze the structure-function relationships in a non-canonical D-amino acid transaminase from Blastococcus saxobsidens, whi …
Vitamin D levels in patients with non-Hodgkin lymphoma/diffuse large B-cell lymphoma, chronic lymphocytic leukemia and multiple myeloma.
Graklanov V, Popov V. Graklanov V, et al. J Int Med Res. 2020 Jul;48(7):300060520943421. doi: 10.1177/0300060520943421. J Int Med Res. 2020. PMID: 32722995 Free PMC article.
RESULTS: Suboptimal serum vitamin D levels (<30 ng/mL) were observed in all 103 patients. In 14 patients, serum vitamin D levels were between 20 and 30 ng/mL, while all other patients had vitamin D deficiency (<20 ng/mL). ...CONCLUSION: We observed low …
RESULTS: Suboptimal serum vitamin D levels (<30 ng/mL) were observed in all 103 patients. In 14 patients, serum vitamin D l …
1,004 results