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Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes.

Maffi P, Lundgren T, Tufveson G, Rafael E, Shaw JAM, Liew A, Saudek F, Witkowski P, Golab K, Bertuzzi F, Gustafsson B, Daffonchio L, Ruffini PA, Piemonti L; REP0211 Study Group. Maffi P, et al. Among authors: daffonchio l. Diabetes Care. 2020 Apr;43(4):710-718. doi: 10.2337/dc19-1480. Epub 2020 Feb 4. Diabetes Care. 2020. PMID: 32019854 Free PMC article. Clinical Trial.

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CXCR1/2 inhibition blocks and reverses type 1 diabetes in mice.

Citro A, Valle A, Cantarelli E, Mercalli A, Pellegrini S, Liberati D, Daffonchio L, Kastsiuchenka O, Ruffini PA, Battaglia M, Allegretti M, Piemonti L. Citro A, et al. Among authors: daffonchio l. Diabetes. 2015 Apr;64(4):1329-40. doi: 10.2337/db14-0443. Epub 2014 Oct 14. Diabetes. 2015. PMID: 25315007 Free article.

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CXCR1/2 inhibition enhances pancreatic islet survival after transplantation.

Citro A, Cantarelli E, Maffi P, Nano R, Melzi R, Mercalli A, Dugnani E, Sordi V, Magistretti P, Daffonchio L, Ruffini PA, Allegretti M, Secchi A, Bonifacio E, Piemonti L. Citro A, et al. Among authors: daffonchio l. J Clin Invest. 2012 Oct;122(10):3647-51. doi: 10.1172/JCI63089. Epub 2012 Sep 17. J Clin Invest. 2012. PMID: 22996693 Free PMC article. Clinical Trial.

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Antioxidant activity of carbocysteine lysine salt monohydrate.

Pinamonti S, Venturoli L, Leis M, Chicca M, Barbieri A, Sostero S, Ravenna F, Daffonchio L, Novellini R, Ciaccia A. Pinamonti S, et al. Among authors: daffonchio l. Panminerva Med. 2001 Sep;43(3):215-20. Panminerva Med. 2001. PMID: 11579333

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S-CMC-Lys-dependent stimulation of electrogenic glutathione secretion by human respiratory epithelium.

Guizzardi F, Rodighiero S, Binelli A, Saino S, Bononi E, Dossena S, Garavaglia ML, Bazzini C, Bottà G, Conese M, Daffonchio L, Novellini R, Paulmichl M, Meyer G. Guizzardi F, et al. Among authors: daffonchio l. J Mol Med (Berl). 2006 Jan;84(1):97-107. doi: 10.1007/s00109-005-0720-y. Epub 2005 Nov 11. J Mol Med (Berl). 2006. PMID: 16283140

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Possible involvement of eicosanoids in the pharmacological action of bromelain.

Vellini M, Desideri D, Milanese A, Omini C, Daffonchio L, Hernandez A, Brunelli G. Vellini M, et al. Among authors: daffonchio l. Arzneimittelforschung. 1986;36(1):110-2. Arzneimittelforschung. 1986. PMID: 3006709

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Effects of levodropropizine on vagal afferent C-fibres in the cat.

Shams H, Daffonchio L, Scheid P. Shams H, et al. Among authors: daffonchio l. Br J Pharmacol. 1996 Mar;117(5):853-8. doi: 10.1111/j.1476-5381.1996.tb15271.x. Br J Pharmacol. 1996. PMID: 8851501 Free PMC article.

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Effectiveness of levodropropizine against cigarette smoke-induced airway hyperreactivity: possible mechanism.

Daffonchio L, Hernandez A, Melillo G, Clavenna G, Omini C. Daffonchio L, et al. Eur J Pharmacol. 1993 Apr 1;228(5-6):257-61. doi: 10.1016/0926-6917(93)90058-x. Eur J Pharmacol. 1993. PMID: 7683266

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Levodropropizine does not affect P0.1 and breathing pattern in healthy volunteers and patients with chronic respiratory impairment.

Bruschi C, Crotti P, Dacosto E, Fanfulla F, Daffonchio L, Novellini R. Bruschi C, et al. Among authors: daffonchio l. Pulm Pharmacol Ther. 2003;16(4):231-6. doi: 10.1016/S1094-5539(03)00053-1. Pulm Pharmacol Ther. 2003. PMID: 12850126 Clinical Trial.

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Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea.

Yamawaki I, Geppetti P, Bertrand C, Huber O, Daffonchio L, Omini C, Nadel JA. Yamawaki I, et al. Among authors: daffonchio l. Eur J Pharmacol. 1993 Oct 12;243(1):1-6. doi: 10.1016/0014-2999(93)90159-f. Eur J Pharmacol. 1993. PMID: 7504629

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