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Investigation of regional mechanisms responsible for poor oral absorption in humans of a modified release preparation of the alpha-adrenoreceptor antagonist, 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4 tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline (UK-338,003): the rational use of ex vivo intestine to predict in vivo absorption.
Collett A, Stephens RH, Harwood MD, Humphrey M, Dallman L, Bennett J, Davis J, Carlson GL, Warhurst G. Collett A, et al. Among authors: dallman l. Drug Metab Dispos. 2008 Jan;36(1):87-94. doi: 10.1124/dmd.107.016865. Epub 2007 Oct 11. Drug Metab Dispos. 2008. PMID: 17932223 Clinical Trial.