Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2007 1
2008 2
2009 1
2010 3
2011 2
2013 4
2015 2
2016 2
2017 3
2018 1
2019 4
2020 4
2021 1
2022 1
2023 2
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

32 results

Results by year

Filters applied: . Clear all
Page 1
The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging.
Wang CL, Ohkubo R, Mu WC, Chen W, Fan JL, Song Z, Maruichi A, Sudmant PH, Pisco AO, Dubal DB, Ji N, Chen D. Wang CL, et al. Among authors: chen d. Cell Metab. 2023 Jun 6;35(6):996-1008.e7. doi: 10.1016/j.cmet.2023.04.012. Epub 2023 May 4. Cell Metab. 2023. PMID: 37146607
Aging results in a decline in neural stem cells (NSCs), neurogenesis, and cognitive function, and evidence is emerging to demonstrate disrupted adult neurogenesis in the hippocampus of patients with several neurodegenerative disorders. ...These results establish the mitoch …
Aging results in a decline in neural stem cells (NSCs), neurogenesis, and cognitive function, and evidence is emerging to demonstrate …
An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance.
He M, Chiang HH, Luo H, Zheng Z, Qiao Q, Wang L, Tan M, Ohkubo R, Mu WC, Zhao S, Wu H, Chen D. He M, et al. Among authors: chen d. Cell Metab. 2020 Mar 3;31(3):580-591.e5. doi: 10.1016/j.cmet.2020.01.009. Epub 2020 Feb 6. Cell Metab. 2020. PMID: 32032542 Free PMC article.
It is well documented that the rate of aging can be slowed, but it remains unclear to which extent aging-associated conditions can be reversed. ...These results establish the dysregulation of the acetylation switch of the NLRP3 inflammasome as an origin of aging …
It is well documented that the rate of aging can be slowed, but it remains unclear to which extent aging-associated conditions …
Mitochondrial regulation in stem cells.
Wang Y, Barthez M, Chen D. Wang Y, et al. Among authors: chen d. Trends Cell Biol. 2023 Oct 31:S0962-8924(23)00207-6. doi: 10.1016/j.tcb.2023.10.003. Online ahead of print. Trends Cell Biol. 2023. PMID: 37919163 Review.
Concomitant mitochondrial stress can lead to loss of stem cell self-renewal and requires the surveillance of various mitochondrial quality control mechanisms. During aging, a mitochondrial protective program mediated by several sirtuins becomes dysregulated and can be targ …
Concomitant mitochondrial stress can lead to loss of stem cell self-renewal and requires the surveillance of various mitochondrial quality c …
The Epigenetics of Stem Cell Aging Comes of Age.
Chen D, Kerr C. Chen D, et al. Trends Cell Biol. 2019 Jul;29(7):563-568. doi: 10.1016/j.tcb.2019.03.006. Epub 2019 Apr 25. Trends Cell Biol. 2019. PMID: 31030975 Free PMC article. Review.
Emerging evidence indicates that epigenetic regulators are critically required for the maintenance of tissue-specific stem cells and that the epigenetic marks are altered in stem cells during physiological aging. Intriguingly, aging-associated stem cell functional d …
Emerging evidence indicates that epigenetic regulators are critically required for the maintenance of tissue-specific stem cells and that th …
Reversing stem cell aging.
Shin J, Mohrin M, Chen D. Shin J, et al. Among authors: chen d. Oncotarget. 2015 Jun 20;6(17):14723-4. doi: 10.18632/oncotarget.4403. Oncotarget. 2015. PMID: 26062656 Free PMC article. No abstract available.
The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation.
Mu WC, Ohkubo R, Widjaja A, Chen D. Mu WC, et al. Among authors: chen d. Mech Ageing Dev. 2020 Jun;188:111254. doi: 10.1016/j.mad.2020.111254. Epub 2020 Apr 25. Mech Ageing Dev. 2020. PMID: 32343979 Free PMC article. Review.
Stem cell aging contributes to aging-associated tissue degeneration and dysfunction. ...Here, we present the evidence supporting the mitochondrial metabolic checkpoint regulating stem cell aging and demonstrating the feasibility to target this checkpoint to r …
Stem cell aging contributes to aging-associated tissue degeneration and dysfunction. ...Here, we present the evidence supporti …
Nutrient Sensing and the Oxidative Stress Response.
Luo H, Chiang HH, Louw M, Susanto A, Chen D. Luo H, et al. Among authors: chen d. Trends Endocrinol Metab. 2017 Jun;28(6):449-460. doi: 10.1016/j.tem.2017.02.008. Epub 2017 Mar 15. Trends Endocrinol Metab. 2017. PMID: 28314502 Free PMC article. Review.
CR reduces levels of oxidative stress and damage, which have been postulated in the free radical theory of aging as a major cause of aging and diseases of aging. This reduction has long been viewed as a result of passive slowing of metabolism. ...Physiologica …
CR reduces levels of oxidative stress and damage, which have been postulated in the free radical theory of aging as a major cause of …
Latest advances in aging research and drug discovery.
Bakula D, Ablasser A, Aguzzi A, Antebi A, Barzilai N, Bittner MI, Jensen MB, Calkhoven CF, Chen D, Grey ADNJ, Feige JN, Georgievskaya A, Gladyshev VN, Golato T, Gudkov AV, Hoppe T, Kaeberlein M, Katajisto P, Kennedy BK, Lal U, Martin-Villalba A, Moskalev AA, Ozerov I, Petr MA, Reason, Rubinsztein DC, Tyshkovskiy A, Vanhaelen Q, Zhavoronkov A, Scheibye-Knudsen M. Bakula D, et al. Among authors: chen d. Aging (Albany NY). 2019 Nov 21;11(22):9971-9981. doi: 10.18632/aging.102487. Epub 2019 Nov 21. Aging (Albany NY). 2019. PMID: 31770722 Free PMC article.
An increasing aging population poses a significant challenge to societies worldwide. ...Several major pharmaceutical, biotechnology, and consumer companies made aging research a priority and are building internal expertise, integrating aging research into tra …
An increasing aging population poses a significant challenge to societies worldwide. ...Several major pharmaceutical, biotechnology, …
Sirtuin regulation in calorie restriction.
Qiu X, Brown KV, Moran Y, Chen D. Qiu X, et al. Among authors: chen d. Biochim Biophys Acta. 2010 Aug;1804(8):1576-83. doi: 10.1016/j.bbapap.2009.09.015. Epub 2009 Sep 24. Biochim Biophys Acta. 2010. PMID: 19782772 Review.
The therapeutic promises of NAD+ boosters.
Montllor-Albalate C, Song Z, Chen D. Montllor-Albalate C, et al. Among authors: chen d. Cell Metab. 2021 Jul 6;33(7):1274-1275. doi: 10.1016/j.cmet.2021.06.008. Cell Metab. 2021. PMID: 34233170 Free article.
Numerous preclinical studies implicate the decline in NAD(+) signaling in developing aging- and obesity-associated metabolic disorders. Yoshino et al. (2021) now provide the clinical evidence that an NAD(+) booster increases muscle insulin sensitivity in postmenopausal pre …
Numerous preclinical studies implicate the decline in NAD(+) signaling in developing aging- and obesity-associated metabolic disorder …
32 results