David Loakes - Search Results

Year	Number of Results
2002	4
2004	4
2005	3
2006	2
2007	8
2008	7
2009	5
2010	2
2012	1
2013	1
2025	0

1

Darwinian chemistry: towards the synthesis of a simple cell.

Loakes D, Holliger P. Loakes D, et al. Mol Biosyst. 2009 Jul;5(7):686-94. doi: 10.1039/b904024b. Epub 2009 May 6. Mol Biosyst. 2009. PMID: 19562107 Review.

2

Evolving a polymerase for hydrophobic base analogues.

Loakes D, Gallego J, Pinheiro VB, Kool ET, Holliger P. Loakes D, et al. J Am Chem Soc. 2009 Oct 21;131(41):14827-37. doi: 10.1021/ja9039696. J Am Chem Soc. 2009. PMID: 19778048 Free PMC article.

3

Molecular breeding of polymerases for amplification of ancient DNA.

d'Abbadie M, Hofreiter M, Vaisman A, Loakes D, Gasparutto D, Cadet J, Woodgate R, Pääbo S, Holliger P. d'Abbadie M, et al. Among authors: loakes d. Nat Biotechnol. 2007 Aug;25(8):939-43. doi: 10.1038/nbt1321. Epub 2007 Jul 15. Nat Biotechnol. 2007. PMID: 17632524 Free PMC article.

4

Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.

Graci JD, Too K, Smidansky ED, Edathil JP, Barr EW, Harki DA, Galarraga JE, Bollinger JM Jr, Peterson BR, Loakes D, Brown DM, Cameron CE. Graci JD, et al. Among authors: loakes d. Antimicrob Agents Chemother. 2008 Mar;52(3):971-9. doi: 10.1128/AAC.01056-07. Epub 2008 Jan 7. Antimicrob Agents Chemother. 2008. PMID: 18180344 Free PMC article.

5

Anti-malarial activity of N6-modified purine analogues.

Too K, Brown DM, Bongard E, Yardley V, Vivas L, Loakes D. Too K, et al. Among authors: loakes d. Bioorg Med Chem. 2007 Aug 15;15(16):5551-62. doi: 10.1016/j.bmc.2007.05.038. Epub 2007 May 18. Bioorg Med Chem. 2007. PMID: 17548196

6

Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).

Eustermann S, Brockmann C, Mehrotra PV, Yang JC, Loakes D, West SC, Ahel I, Neuhaus D. Eustermann S, et al. Among authors: loakes d. Nat Struct Mol Biol. 2010 Feb;17(2):241-3. doi: 10.1038/nsmb.1747. Epub 2010 Jan 24. Nat Struct Mol Biol. 2010. PMID: 20098424 Free PMC article.

7

Polymerase engineering: towards the encoded synthesis of unnatural biopolymers.

Loakes D, Holliger P. Loakes D, et al. Chem Commun (Camb). 2009 Aug 21;(31):4619-31. doi: 10.1039/b903307f. Epub 2009 Jul 6. Chem Commun (Camb). 2009. PMID: 19641798

8

Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution.

Ghadessy FJ, Ramsay N, Boudsocq F, Loakes D, Brown A, Iwai S, Vaisman A, Woodgate R, Holliger P. Ghadessy FJ, et al. Among authors: loakes d. Nat Biotechnol. 2004 Jun;22(6):755-9. doi: 10.1038/nbt974. Epub 2004 May 23. Nat Biotechnol. 2004. PMID: 15156154

9

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome.

Voorhees RM, Weixlbaumer A, Loakes D, Kelley AC, Ramakrishnan V. Voorhees RM, et al. Among authors: loakes d. Nat Struct Mol Biol. 2009 May;16(5):528-33. doi: 10.1038/nsmb.1577. Epub 2009 Apr 12. Nat Struct Mol Biol. 2009. PMID: 19363482 Free PMC article.

10

Template properties of mutagenic cytosine analogues in reverse transcription.

Suzuki T, Moriyama K, Otsuka C, Loakes D, Negishi K. Suzuki T, et al. Among authors: loakes d. Nucleic Acids Res. 2006;34(22):6438-49. doi: 10.1093/nar/gkl761. Epub 2006 Nov 27. Nucleic Acids Res. 2006. PMID: 17130163 Free PMC article.

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