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Novel insights from a multiomics dissection of the Hayflick limit.
Chan M, Yuan H, Soifer I, Maile TM, Wang RY, Ireland A, O'Brien JJ, Goudeau J, Chan LJG, Vijay T, Freund A, Kenyon C, Bennett BD, McAllister FE, Kelley DR, Roy M, Cohen RL, Levinson AD, Botstein D, Hendrickson DG. Chan M, et al. Among authors: botstein d. Elife. 2022 Feb 4;11:e70283. doi: 10.7554/eLife.70283. Elife. 2022. PMID: 35119359 Free PMC article.
The process wherein dividing cells exhaust proliferative capacity and enter into replicative senescence has become a prominent model for cellular aging in vitro. Despite decades of study, this cellular state is not fully understood in culture and even much less so during …
The process wherein dividing cells exhaust proliferative capacity and enter into replicative senescence has become a prominent model for cel …
Loss of major nutrient sensing and signaling pathways suppresses starvation lethality in electron transport chain mutants.
Lewis AG, Caldwell R, Rogers JV, Ingaramo M, Wang RY, Soifer I, Hendrickson DG, McIsaac RS, Botstein D, Gibney PA. Lewis AG, et al. Among authors: botstein d. Mol Biol Cell. 2021 Dec 1;32(22):ar39. doi: 10.1091/mbc.E21-06-0314. Epub 2021 Oct 20. Mol Biol Cell. 2021. PMID: 34668730 Free PMC article.
ETC mutations are associated with a wide array of human disease conditions and to aging-related phenotypes in a number of different organisms. In this study, we sought to better understand the role of the ETC in aging using a yeast model. ...This work further highli …
ETC mutations are associated with a wide array of human disease conditions and to aging-related phenotypes in a number of different o …
System-level analysis of genes and functions affecting survival during nutrient starvation in Saccharomyces cerevisiae.
Gresham D, Boer VM, Caudy A, Ziv N, Brandt NJ, Storey JD, Botstein D. Gresham D, et al. Among authors: botstein d. Genetics. 2011 Jan;187(1):299-317. doi: 10.1534/genetics.110.120766. Epub 2010 Oct 13. Genetics. 2011. PMID: 20944018 Free PMC article.
Our experimental and analytical methods represent an efficient and quantitative approach to characterizing genetic functions and networks with unprecedented resolution and identified genotype-by-environment interactions that have important implications for interpretation of studi …
Our experimental and analytical methods represent an efficient and quantitative approach to characterizing genetic functions and networks wi …
Influence of genotype and nutrition on survival and metabolism of starving yeast.
Boer VM, Amini S, Botstein D. Boer VM, et al. Among authors: botstein d. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6930-5. doi: 10.1073/pnas.0802601105. Epub 2008 May 2. Proc Natl Acad Sci U S A. 2008. PMID: 18456835 Free PMC article.
Furthermore, we suggest that our results on condition-dependent chronological lifespan have important implications for the interpretation and design of studies on chronological aging....
Furthermore, we suggest that our results on condition-dependent chronological lifespan have important implications for the interpretation an …