The prediction of Alzheimer's disease through multi-trait genetic modeling.
Clark K, Fu W, Liu CL, Ho PC, Wang H, Lee WP, Chou SY, Wang LS, Tzeng JY.
Clark K, et al.
Front Aging Neurosci. 2023 Jul 27;15:1168638. doi: 10.3389/fnagi.2023.1168638. eCollection 2023.
Front Aging Neurosci. 2023.
PMID: 37577355
Free PMC article.
One standard deviation increase in the MetaGRS is associated with about 57% increase in the AD risk [hazard ratio (HR) = 1.577, p = 7.17 E-56], showing little difference from the HR for AD GRS alone (HR = 1.579, p = 1.20E-56), suggesting similar utility of both models. We …
One standard deviation increase in the MetaGRS is associated with about 57% increase in the AD risk [hazard ratio (HR) = 1.577, p = 7.17 E-5 …