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Dchs1-Fat4 regulation of osteogenic differentiation in mouse.
Crespo-Enriquez I, Hodgson T, Zakaria S, Cadoni E, Shah M, Allen S, Al-Khishali A, Mao Y, Yiu A, Petzold J, Villagomez-Olea G, Pitsillides AA, Irvine KD, Francis-West P. Crespo-Enriquez I, et al. Development. 2019 Jul 29;146(14):dev176776. doi: 10.1242/dev.176776. Development. 2019. PMID: 31358536 Free PMC article.
Here, we analyse the role of Dchs1-Fat4 signalling during osteoblast differentiation in mouse. We show that Fat4 and Dchs1 mutants mimic the craniofacial phenotype of the human syndrome and that Dchs1-Fat4 signalling is essential for osteoblast differentiatio …
Here, we analyse the role of Dchs1-Fat4 signalling during osteoblast differentiation in mouse. We show that Fat4 and Dchs1 mut …
DCHS1 DNA copy number loss associated with pediatric urinary tract infection risk.
Qureshi AH, Liang D, Canas J, Hooks J, Arrregui SW, Saxena V, Rooney R, Nolan V, Schwaderer AL, Hains DS. Qureshi AH, et al. Innate Immun. 2020 Aug;26(6):473-481. doi: 10.1177/1753425920917193. Epub 2020 Apr 15. Innate Immun. 2020. PMID: 32295462 Free PMC article. Clinical Trial.
We investigated a novel gene, Dachsous Cadherin-Related 1 (DCHS1), in children with UTI. We determined absolute DNA copy number (CN) of DCHS1 in children with UTI. ...Less than 1% of controls had a single copy of DCHS1, while 31% of children with UTI and no V …
We investigated a novel gene, Dachsous Cadherin-Related 1 (DCHS1), in children with UTI. We determined absolute DNA copy number (CN) …
DCHS1, Lix1L, and the Septin Cytoskeleton: Molecular and Developmental Etiology of Mitral Valve Prolapse.
Moore KS, Moore R, Fulmer DB, Guo L, Gensemer C, Stairley R, Glover J, Beck TC, Morningstar JE, Biggs R, Muhkerjee R, Awgulewitsch A, Norris RA. Moore KS, et al. J Cardiovasc Dev Dis. 2022 Feb 17;9(2):62. doi: 10.3390/jcdd9020062. J Cardiovasc Dev Dis. 2022. PMID: 35200715 Free PMC article.
This study focuses on the developmental function of DCHS1, one of the first genes to be shown as causal in multiple families with non-syndromic MVP. ...This DCHS1-LIX1L-SEPT9 axis interacts with and promotes filamentous actin organization to direct cell-ECM alignmen …
This study focuses on the developmental function of DCHS1, one of the first genes to be shown as causal in multiple families with non …
Mutations in DCHS1 cause mitral valve prolapse.
Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA. Durst R, et al. Nature. 2015 Sep 3;525(7567):109-13. doi: 10.1038/nature14670. Epub 2015 Aug 10. Nature. 2015. PMID: 26258302 Free PMC article.
Morpholino knockdown of the zebrafish homologue dachsous1b resulted in a cardiac atrioventricular canal defect that could be rescued by wild-type human DCHS1, but not by DCHS1 messenger RNA with the familial mutation. Further genetic studies identified two additiona …
Morpholino knockdown of the zebrafish homologue dachsous1b resulted in a cardiac atrioventricular canal defect that could be rescued by wild …
Dchs1-Fat4 regulation of polarized cell behaviours during skeletal morphogenesis.
Mao Y, Kuta A, Crespo-Enriquez I, Whiting D, Martin T, Mulvaney J, Irvine KD, Francis-West P. Mao Y, et al. Nat Commun. 2016 May 5;7:11469. doi: 10.1038/ncomms11469. Nat Commun. 2016. PMID: 27145737 Free PMC article.
An example of extreme diversity in the shape of a skeletal structure can be seen in the sternum, which varies considerably across species. Here we show that the Dchs1-Fat4 planar cell polarity pathway controls cell orientation in the early skeletal condensation to define t …
An example of extreme diversity in the shape of a skeletal structure can be seen in the sternum, which varies considerably across species. H …
Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae.
Kuta A, Mao Y, Martin T, Ferreira de Sousa C, Whiting D, Zakaria S, Crespo-Enriquez I, Evans P, Balczerski B, Mankoo B, Irvine KD, Francis-West PH. Kuta A, et al. Development. 2016 Jul 1;143(13):2367-75. doi: 10.1242/dev.131037. Development. 2016. PMID: 27381226 Free PMC article.
The protocadherins Fat4 and Dchs1 act as a receptor-ligand pair to regulate many developmental processes in mice and humans, including development of the vertebrae. ...Analysis of Fat4;Yap and Fat4;Taz double mutants, and expression of their transcriptional target Ctgf, in …
The protocadherins Fat4 and Dchs1 act as a receptor-ligand pair to regulate many developmental processes in mice and humans, includin …
Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching.
Mao Y, Francis-West P, Irvine KD. Mao Y, et al. Development. 2015 Aug 1;142(15):2574-85. doi: 10.1242/dev.122630. Epub 2015 Jun 26. Development. 2015. PMID: 26116666 Free PMC article.
Genetically, Dchs1 is required specifically within cap mesenchyme cells. The similarity of Dchs1 phenotypes to stromal-less kidneys and to those of Fat4 mutants implicates Dchs1 in Fat4-dependent stroma-to-cap mesenchyme signaling. ...Our observations identif …
Genetically, Dchs1 is required specifically within cap mesenchyme cells. The similarity of Dchs1 phenotypes to stromal-less ki …
Mutation in mitral valve prolapse susceptible gene DCHS1 causes familial mitral annular disjunction.
Zhou N, Zhao Q, Li R, Cheng R, Wu Q, Cheng J, Chen Y. Zhou N, et al. J Med Genet. 2024 Jan 19;61(2):125-131. doi: 10.1136/jmg-2023-109278. J Med Genet. 2024. PMID: 37399314
Exclusively, 12 ultra-rare deleterious variants distributed in nine genes occurred in LE-MAD, which were ANK1, COL3A1, DCHS1, FBN2, GNPTAB, LZTR1, PLD1, RYR1 and VPS13B. Ultra-rare deleterious variants in those nine genes were predominantly distributed in LE-MAD compared w …
Exclusively, 12 ultra-rare deleterious variants distributed in nine genes occurred in LE-MAD, which were ANK1, COL3A1, DCHS1, FBN2, G …
Dachsous cadherin related 1 (DCHS1) is a novel biomarker for immune infiltration and epithelial-mesenchymal transition in endometrial cancer via pan-cancer analysis.
Meijuan C, Fang M, Qian W. Meijuan C, et al. J Ovarian Res. 2024 Aug 9;17(1):162. doi: 10.1186/s13048-024-01478-1. J Ovarian Res. 2024. PMID: 39123216 Free PMC article.
In addition, DCHS1 was significantly associated with sensitivity to many antitumor drugs. Functional enrichment analysis revealed that DCHS1-related proteins were involved in Focal adhesion, Endometrial cancer and Wnt signaling pathway. GSEA results showed that D …
In addition, DCHS1 was significantly associated with sensitivity to many antitumor drugs. Functional enrichment analysis revealed tha …
63 results