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Page 1
DCX-Related Disorders.
Geis T, Uyanik G, Aigner L, Couillard-Despres S, Winkler J, Hehr U. Geis T, et al. 2007 Oct 19 [updated 2025 Jun 5]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. 2007 Oct 19 [updated 2025 Jun 5]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. PMID: 20301364 Free Books & Documents. Review.
DIAGNOSIS/TESTING: The diagnosis of a DCX-related disorder is established in a proband with a DCX pathogenic variant identified by molecular genetic testing. ...Males who inherit the pathogenic variant will usually be affected with DCX-related classic lissenc …
DIAGNOSIS/TESTING: The diagnosis of a DCX-related disorder is established in a proband with a DCX pathogenic variant identifie …
Connecting DCX, COMT and FMR1 in social behavior and cognitive impairment.
Delprato A, Xiao E, Manoj D. Delprato A, et al. Behav Brain Funct. 2022 May 19;18(1):7. doi: 10.1186/s12993-022-00191-7. Behav Brain Funct. 2022. PMID: 35590332 Free PMC article.
Genetic variants of DCX, COMT and FMR1 have been linked to neurodevelopmental disorders related to intellectual disability and social behavior. ...Taken together our findings indicate that factors connecting DCX, COMT, and FMR1 in intellectual disability and social …
Genetic variants of DCX, COMT and FMR1 have been linked to neurodevelopmental disorders related to intellectual disability and social …
DCX-EMAP is a core organizer for the ultrastructure of Drosophila mechanosensory organelles.
Song X, Cui L, Wu M, Wang S, Song Y, Liu Z, Xue Z, Chen W, Zhang Y, Li H, Sun L, Liang X. Song X, et al. J Cell Biol. 2023 Oct 2;222(10):e202209116. doi: 10.1083/jcb.202209116. Epub 2023 Aug 31. J Cell Biol. 2023. PMID: 37651176 Free PMC article.
We show that the main structure of the MOs is a compound cytoskeleton formed of short microtubules and electron-dense materials (EDMs). In a knock-out mutant of DCX-EMAP, this cytoskeleton is nearly absent, suggesting that DCX-EMAP is required for the formation of t …
We show that the main structure of the MOs is a compound cytoskeleton formed of short microtubules and electron-dense materials (EDMs). In a …
DCX(+) cells cripple systemic spleen immunity and promote tumor progression.
Ren D, He Y, Lu C, Fu Y, Wang Y, Hu Q, Ni Y, Song Y, Li Y, Ding L. Ren D, et al. Brain Behav Immun. 2025 Nov;130:106076. doi: 10.1016/j.bbi.2025.106076. Epub 2025 Aug 14. Brain Behav Immun. 2025. PMID: 40818614
Notably, DCX was absent in murine tumor tissues and spleen, suggesting that DCX-mediated systemic immune regulation exclusively involved brain DCX(+) cells, which functionally connected to peripheral sympathetic innervation of ADRB2(+) splenic immune cells. D …
Notably, DCX was absent in murine tumor tissues and spleen, suggesting that DCX-mediated systemic immune regulation exclusivel …
DCX knockout ferret reveals a neurogenic mechanism in cortical development.
Wang W, Yin C, Wen S, Liu Z, Wang B, Zeng B, Sun L, Zhou X, Zhong S, Zhang J, Ma W, Wu Q, Wang X. Wang W, et al. Cell Rep. 2024 Aug 27;43(8):114508. doi: 10.1016/j.celrep.2024.114508. Epub 2024 Jul 16. Cell Rep. 2024. PMID: 39018244 Free article.
Lissencephaly is a rare brain malformation for which our understanding remains limited due to the absence of suitable animal models that accurately represent human phenotypes. Here, we establish doublecortin (DCX) knockout ferrets as a model that faithfully replicates key …
Lissencephaly is a rare brain malformation for which our understanding remains limited due to the absence of suitable animal models that acc …
DCX's phosphorylation by not just another kinase (JNK).
Reiner O, Gdalyahu A, Ghosh I, Levy T, Sapoznik S, Nir R, Sapir T. Reiner O, et al. Cell Cycle. 2004 Jun;3(6):747-51. Epub 2004 Jun 6. Cell Cycle. 2004. PMID: 15118415 Review.
This organized cortical layering is disrupted in case of mutations in the doublecortin (DCX) gene. DCX is a Microtubule Associated Protein (MAP). However, besides stabilization of microtubules, it may be involved in additional functions. ...Positioning of DCX …
This organized cortical layering is disrupted in case of mutations in the doublecortin (DCX) gene. DCX is a Microtubule Associ …
DCX(+) neuronal progenitors contribute to new oligodendrocytes during remyelination in the hippocampus.
Klein B, Mrowetz H, Kreutzer C, Rotheneichner P, Zaunmair P, Lange S, Coras R, Couillard-Despres S, Rivera FJ, Aigner L. Klein B, et al. Sci Rep. 2020 Nov 18;10(1):20095. doi: 10.1038/s41598-020-77115-w. Sci Rep. 2020. PMID: 33208869 Free PMC article.
The aim of this study was to investigate whether hippocampal DCX(+) NPCs can generate new oligodendrocytes under conditions in which myelin repair is required. For this, the cell fate of DCX-expressing NPCs was analyzed during cuprizone-induced demyelination and sub …
The aim of this study was to investigate whether hippocampal DCX(+) NPCs can generate new oligodendrocytes under conditions in which …
Progenitors from the central nervous system drive neurogenesis in cancer.
Mauffrey P, Tchitchek N, Barroca V, Bemelmans AP, Firlej V, Allory Y, Roméo PH, Magnon C. Mauffrey P, et al. Nature. 2019 May;569(7758):672-678. doi: 10.1038/s41586-019-1219-y. Epub 2019 May 15. Nature. 2019. PMID: 31092925
In mouse models of prostate cancer, oscillations of DCX(+) neural progenitors in the subventricular zone-a neurogenic area of the central nervous system-are associated with disruption of the blood-brain barrier, and with the egress of DCX(+) cells into the circulati …
In mouse models of prostate cancer, oscillations of DCX(+) neural progenitors in the subventricular zone-a neurogenic area of the cen …
No DCX-positive neurogenesis in the cerebral cortex of the adult primate.
Liu RX, Ma J, Wang B, Tian T, Guo N, Liu SJ. Liu RX, et al. Neural Regen Res. 2020 Jul;15(7):1290-1299. doi: 10.4103/1673-5374.272610. Neural Regen Res. 2020. PMID: 31960815 Free PMC article.
An increasing number of reports suggest that doublecortin (DCX)-positive neurogenesis persists in the adult primate cortex, attracting enormous attention worldwide. ...We found either strong fluorescent signals, medium-weak intensity signals in some cells, weak signals in …
An increasing number of reports suggest that doublecortin (DCX)-positive neurogenesis persists in the adult primate cortex, attractin …
Dcx expression defines a subpopulation of Gdf5 (+) cells with chondrogenic potentials in E12.5 mouse embryonic limbs.
Lan R, Ge D, Liu YZ, You Z. Lan R, et al. Biochem Biophys Rep. 2022 Jan 5;29:101200. doi: 10.1016/j.bbrep.2022.101200. eCollection 2022 Mar. Biochem Biophys Rep. 2022. PMID: 35036586 Free PMC article.
Growth differentiation factor 5 (Gdf5) and doublecortin (Dcx) genes are both expressed in joint interzone cells during synovial joint development. ...Dcx (+) and Dcx (-) cells had differential gene expression profiles. The up-regulated genes in Dcx (+) …
Growth differentiation factor 5 (Gdf5) and doublecortin (Dcx) genes are both expressed in joint interzone cells during synovial joint …
2,771 results