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164 results

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Page 1
Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation.
Miao W, Porter DF, Lopez-Pajares V, Siprashvili Z, Meyers RM, Bai Y, Nguyen DT, Ko LA, Zarnegar BJ, Ferguson ID, Mills MM, Jilly-Rehak CE, Wu CG, Yang YY, Meyers JM, Hong AW, Reynolds DL, Ramanathan M, Tao S, Jiang S, Flynn RA, Wang Y, Nolan GP, Khavari PA. Miao W, et al. Cell. 2023 Jan 5;186(1):80-97.e26. doi: 10.1016/j.cell.2022.12.004. Cell. 2023. PMID: 36608661 Free PMC article.
Azido-glucose click chemistry identified glucose binding to a variety of RNA binding proteins (RBPs), including the DDX21 RNA helicase, which was found to be essential for epidermal differentiation. Glucose bound the ATP-binding domain of DDX21, altering protein con …
Azido-glucose click chemistry identified glucose binding to a variety of RNA binding proteins (RBPs), including the DDX21 RNA helicas …
DDX21 mediates co-transcriptional RNA m(6)A modification to promote transcription termination and genome stability.
Hao JD, Liu QL, Liu MX, Yang X, Wang LM, Su SY, Xiao W, Zhang MQ, Zhang YC, Zhang L, Chen YS, Yang YG, Ren J. Hao JD, et al. Mol Cell. 2024 May 2;84(9):1711-1726.e11. doi: 10.1016/j.molcel.2024.03.006. Epub 2024 Apr 2. Mol Cell. 2024. PMID: 38569554 Free article.
Moreover, DDX21's helicase activity is needed for METTL3-mediated m(6)A deposition onto nascent RNA following recruitment. ...Disruption of any of these steps, including the loss of DDX21, METTL3, or their enzymatic activities, leads to defective termination that ca …
Moreover, DDX21's helicase activity is needed for METTL3-mediated m(6)A deposition onto nascent RNA following recruitment. ...Disrupt …
SLERT Regulates DDX21 Rings Associated with Pol I Transcription.
Xing YH, Yao RW, Zhang Y, Guo CJ, Jiang S, Xu G, Dong R, Yang L, Chen LL. Xing YH, et al. Cell. 2017 May 4;169(4):664-678.e16. doi: 10.1016/j.cell.2017.04.011. Cell. 2017. PMID: 28475895 Free article.
Mechanistically, SLERT interacts with DEAD-box RNA helicase DDX21 via a 143-nt non-snoRNA sequence. Super-resolution images reveal that DDX21 forms ring-shaped structures surrounding multiple Pol I complexes and suppresses pre-rRNA transcription. Binding by SLERT al …
Mechanistically, SLERT interacts with DEAD-box RNA helicase DDX21 via a 143-nt non-snoRNA sequence. Super-resolution images reveal th …
Phase separation of DDX21 promotes colorectal cancer metastasis via MCM5-dependent EMT pathway.
Gao H, Wei H, Yang Y, Li H, Liang J, Ye J, Zhang F, Wang L, Shi H, Wang J, Han A. Gao H, et al. Oncogene. 2023 May;42(21):1704-1715. doi: 10.1038/s41388-023-02687-6. Epub 2023 Apr 7. Oncogene. 2023. PMID: 37029300 Free PMC article.
The impaired metastatic ability of CRC upon DDX21 loss is restored by ectopic expression of MCM5, indicating MCM5 is a key downstream target of DDX21 for CRC metastasis. ...Altogether, our results elucidate a new model of DDX21 in regulating CRC metastasis vi …
The impaired metastatic ability of CRC upon DDX21 loss is restored by ectopic expression of MCM5, indicating MCM5 is a key downstream …
RNA helicase DDX21 coordinates transcription and ribosomal RNA processing.
Calo E, Flynn RA, Martin L, Spitale RC, Chang HY, Wysocka J. Calo E, et al. Nature. 2015 Feb 12;518(7538):249-53. doi: 10.1038/nature13923. Epub 2014 Nov 24. Nature. 2015. PMID: 25470060 Free PMC article.
Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (Pol) I and II to control multiple steps of ribosome biogenesis in human cells. ...Our results uncover the multifaceted role of DDX21 in multiple steps of r …
Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (Pol) I and II to contr …
DDX21 at the Nexus of RNA Metabolism, Cancer Oncogenesis, and Host-Virus Crosstalk: Decoding Its Biomarker Potential and Therapeutic Implications.
Xiao Y, Fan J, Li Z, Hou Y. Xiao Y, et al. Int J Mol Sci. 2024 Dec 19;25(24):13581. doi: 10.3390/ijms252413581. Int J Mol Sci. 2024. PMID: 39769343 Free PMC article. Review.
DDX21, a member of the DEAD-box RNA helicase family, plays a pivotal role in various aspects of RNA metabolism, including ribosomal RNA (rRNA) processing, transcription, and translation. ...Additionally, DDX21 plays a key role in the antiviral defense of host by int …
DDX21, a member of the DEAD-box RNA helicase family, plays a pivotal role in various aspects of RNA metabolism, including ribosomal R …
Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21.
Kim DS, Camacho CV, Nagari A, Malladi VS, Challa S, Kraus WL. Kim DS, et al. Mol Cell. 2019 Sep 19;75(6):1270-1285.e14. doi: 10.1016/j.molcel.2019.06.020. Epub 2019 Jul 24. Mol Cell. 2019. PMID: 31351877 Free PMC article.
Treatment with PARPi or mutation of the ADP-ribosylation sites reduces DDX21 nucleolar localization, rDNA transcription, ribosome biogenesis, protein translation, and cell growth. ...Elevated levels of PARP-1 and nucleolar DDX21 are associated with cancer-related ou …
Treatment with PARPi or mutation of the ADP-ribosylation sites reduces DDX21 nucleolar localization, rDNA transcription, ribosome bio …
NAT10 resolves harmful nucleolar R-loops depending on its helicase domain and acetylation of DDX21.
Su K, Zhao Z, Wang Y, Sun S, Liu X, Zhang C, Jiang Y, Du X. Su K, et al. Cell Commun Signal. 2024 Oct 11;22(1):490. doi: 10.1186/s12964-024-01869-3. Cell Commun Signal. 2024. PMID: 39394182 Free PMC article.
Further, the acetyltransferase activity of NAT10 is required for the nucleolar R-loop resolution. NAT10 acetylates DDX21 at K236 and K573 to enhance the helicase activity of DDX21 to unwind nucleolar R-loops. The helicase activity of DDX21 significantly decre …
Further, the acetyltransferase activity of NAT10 is required for the nucleolar R-loop resolution. NAT10 acetylates DDX21 at K236 and …
TRIP13 regulates progression of gastric cancer through stabilising the expression of DDX21.
Zhang G, Yang R, Wang B, Yan Q, Zhao P, Zhang J, Su W, Yang L, Cui H. Zhang G, et al. Cell Death Dis. 2024 Aug 26;15(8):622. doi: 10.1038/s41419-024-07012-x. Cell Death Dis. 2024. PMID: 39187490 Free PMC article.
Mechanistically, this study confirms that TRIP13 directly interacts with DDX21 and stabilises its expression by restraining its ubiquitination degradation, thereby promoting gastric cancer progression. ...These results indicate that TRIP13 serve is a promising biomarker fo …
Mechanistically, this study confirms that TRIP13 directly interacts with DDX21 and stabilises its expression by restraining its ubiqu …
DDX21: The link between m(6)A and R-loops.
Lavergne G, Roignant JY. Lavergne G, et al. Mol Cell. 2024 May 2;84(9):1631-1632. doi: 10.1016/j.molcel.2024.04.005. Mol Cell. 2024. PMID: 38701738 Free article.
In this issue of Molecular Cell, Hao et al.(1) demonstrate that the RNA helicase DDX21 recruits the m(6)A methyltransferase complex to R-loops, ensuring proper transcription termination and genome stability....
In this issue of Molecular Cell, Hao et al.(1) demonstrate that the RNA helicase DDX21 recruits the m(6)A methyltransferase complex t …
164 results