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Year Number of Results
1969 1
2002 3
2003 1
2004 1
2011 3
2012 1
2013 3
2014 1
2015 2
2016 3
2018 4
2019 3
2020 1
2021 0
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Page 1
Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility.
Guan J, Zhou W, Hafner M, Blake RA, Chalouni C, Chen IP, De Bruyn T, Giltnane JM, Hartman SJ, Heidersbach A, Houtman R, Ingalla E, Kategaya L, Kleinheinz T, Li J, Martin SE, Modrusan Z, Nannini M, Oeh J, Ubhayakar S, Wang X, Wertz IE, Young A, Yu M, Sampath D, Hager JH, Friedman LS, Daemen A, Metcalfe C. Guan J, et al. Among authors: de bruyn t. Cell. 2019 Aug 8;178(4):949-963.e18. doi: 10.1016/j.cell.2019.06.026. Epub 2019 Jul 25. Cell. 2019. PMID: 31353221 Free article.
Disruption of IRE1α through its kinase domain attenuates multiple myeloma.
Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen YA, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun MG, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A. Harnoss JM, et al. Among authors: de bruyn t. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16420-16429. doi: 10.1073/pnas.1906999116. Epub 2019 Aug 1. Proc Natl Acad Sci U S A. 2019. PMID: 31371506 Free PMC article.
Drug-induced cholestasis assay in primary hepatocytes.
Van Brantegem P, Chatterjee S, De Bruyn T, Annaert P, Deferm N. Van Brantegem P, et al. Among authors: de bruyn t. MethodsX. 2020 Sep 25;7:101080. doi: 10.1016/j.mex.2020.101080. eCollection 2020. MethodsX. 2020. PMID: 33088729 Free PMC article.
Novel natural and synthetic inhibitors of solute carriers SGLT1 and SGLT2.
Oranje P, Gouka R, Burggraaff L, Vermeer M, Chalet C, Duchateau G, van der Pijl P, Geldof M, de Roo N, Clauwaert F, Vanpaeschen T, Nicolaï J, de Bruyn T, Annaert P, IJzerman AP, van Westen GJP. Oranje P, et al. Among authors: de bruyn t. Pharmacol Res Perspect. 2019 Jul 30;7(4):e00504. doi: 10.1002/prp2.504. eCollection 2019 Aug. Pharmacol Res Perspect. 2019. PMID: 31384471 Free PMC article.
Structure-based identification of OATP1B1/3 inhibitors.
De Bruyn T, van Westen GJ, Ijzerman AP, Stieger B, de Witte P, Augustijns PF, Annaert PP. De Bruyn T, et al. Mol Pharmacol. 2013 Jun;83(6):1257-67. doi: 10.1124/mol.112.084152. Epub 2013 Apr 9. Mol Pharmacol. 2013. PMID: 23571415
Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes.
Nicolaï J, De Bruyn T, Thevelin L, Augustijns P, Annaert P. Nicolaï J, et al. Among authors: de bruyn t. Drug Metab Dispos. 2016 Mar;44(3):389-97. doi: 10.1124/dmd.115.068114. Epub 2015 Dec 28. Drug Metab Dispos. 2016. PMID: 26712820
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