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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.
Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G; Genomics England Research Consortium; de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. Prentzell MT, et al. Among authors: de meulemeester as. Cell. 2021 Feb 4;184(3):655-674.e27. doi: 10.1016/j.cell.2020.12.024. Epub 2021 Jan 25. Cell. 2021. PMID: 33497611 Free PMC article.
Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish.
Heylen L, Pham DH, De Meulemeester AS, Samarut É, Skiba A, Copmans D, Kazwiny Y, Vanden Berghe P, de Witte PAM, Siekierska A. Heylen L, et al. Among authors: de meulemeester as. Front Mol Neurosci. 2021 Oct 14;14:753936. doi: 10.3389/fnmol.2021.753936. eCollection 2021. Front Mol Neurosci. 2021. PMID: 34720874 Free PMC article.
Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities.
De Meulemeester AS, Heylen L, Siekierska A, Mills JD, Romagnolo A, Van Der Wel NN, Aronica E, de Witte PAM. De Meulemeester AS, et al. Front Cell Dev Biol. 2022 Sep 27;10:952832. doi: 10.3389/fcell.2022.952832. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36238691 Free PMC article.