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Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts.
Sanchez C, Deberg MA, Piccardi N, Msika P, Reginster JY, Henrotin YE. Sanchez C, et al. Among authors: deberg ma. Osteoarthritis Cartilage. 2005 Nov;13(11):979-87. doi: 10.1016/j.joca.2005.03.008. Osteoarthritis Cartilage. 2005. PMID: 16243232 Free article.