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Page 1
Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation.
Antón-Plágaro C, Chen KE, Guo Q, Liu M, Evans AJ, Lewis PA, Heesom KJ, Wilkinson KA, Collins BM, Cullen PJ. Antón-Plágaro C, et al. Nat Commun. 2025 Jul 30;16(1):6990. doi: 10.1038/s41467-025-61802-1. Nat Commun. 2025. PMID: 40738907 Free PMC article.
Combining X-ray crystallography and in silico predictions with biochemical and cellular analysis, we reveal that Retromer directly associates and recruits the RAB10 regulators DENND4A, DENND4C, TBC1D1, and TBC1D4, and the RAB35 regulator TBC1D13 to regulate retrieval sub-d …
Combining X-ray crystallography and in silico predictions with biochemical and cellular analysis, we reveal that Retromer directly associate …
TDP-43 enhances translation of specific mRNAs linked to neurodegenerative disease.
Neelagandan N, Gonnella G, Dang S, Janiesch PC, Miller KK, Küchler K, Marques RF, Indenbirken D, Alawi M, Grundhoff A, Kurtz S, Duncan KE. Neelagandan N, et al. Nucleic Acids Res. 2019 Jan 10;47(1):341-361. doi: 10.1093/nar/gky972. Nucleic Acids Res. 2019. PMID: 30357366 Free PMC article.
In contrast, translational enhancement of Dennd4a mRNA required a specific 3'UTR region and was specifically observed with the TDP-43A315T patient mutant allele. Our data reveal that TDP-43 can function as an mRNA-specific translational enhancer. Moreover, since CAMTA1 and …
In contrast, translational enhancement of Dennd4a mRNA required a specific 3'UTR region and was specifically observed with the TDP-43 …
Epigenetic Insights into Vascular Cognitive Impairment: DNA Methylation in the Human Brain Tissue.
Vishweswaraiah S, Saiyed N, Khalid A, Milčiūtė M, Gabrielaite M, Buyuker C, Aksakal B, Gomes L, Gordevicius J, Yilmaz A, Graham SF. Vishweswaraiah S, et al. Mol Neurobiol. 2025 Oct;62(10):13650-13664. doi: 10.1007/s12035-025-05119-6. Epub 2025 Jun 24. Mol Neurobiol. 2025. PMID: 40551051
Notably, hypermethylation was detected in key genes related to neurodegeneration and vascular health, such as MTCH2, DPRX, and DENND4A. GSEA identified critical pathways related to neuronal function and vascular health. ...
Notably, hypermethylation was detected in key genes related to neurodegeneration and vascular health, such as MTCH2, DPRX, and DENND4A …
Genome-Wide Association Studies Reveal Candidate Genes Associated with Pigmentation Patterns of Single Feathers of Tianfu Nonghua Ducks.
Twumasi G, Wang H, Xi Y, Qi J, Li L, Bai L, Liu H. Twumasi G, et al. Animals (Basel). 2023 Dec 26;14(1):85. doi: 10.3390/ani14010085. Animals (Basel). 2023. PMID: 38200816 Free PMC article.
This study also revealed that five candidate genes, including DPP8, HACD3, INTS14, SLC24A1, and DENND4A, were associated with the color pigment on the dorsal feathers of the ducks. Genes such as PRKG1, SETD6, RALYL, and ZNF704 reportedly play important roles in ventral fea …
This study also revealed that five candidate genes, including DPP8, HACD3, INTS14, SLC24A1, and DENND4A, were associated with the col …
High-throughput transcriptome analysis reveals potentially important relationships between lncRNAs and genes in broilers affected by Valgus-varus Deformity (Gallus gallus).
Guo Y, Tang H, Li Z, Zhang Y, Li D, Li W, Sun G, Kang X, Han R. Guo Y, et al. Gene. 2020 Jun 15;743:144511. doi: 10.1016/j.gene.2020.144511. Epub 2020 Feb 26. Gene. 2020. PMID: 32112984
Analysis of the network showed that the differentially expressed mRNAs and the target genes of the differentially expressed lncRNAs were enriched in the signaling pathways associated with bone development, including p53, MAPK, Toll-like receptor, Jak-STAT, Hedgehog, and PPAR. The …
Analysis of the network showed that the differentially expressed mRNAs and the target genes of the differentially expressed lncRNAs were enr …
Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.
Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU. Soragni A, et al. Mol Cell. 2015 Mar 19;57(6):1011-1021. doi: 10.1016/j.molcel.2015.01.026. Epub 2015 Feb 26. Mol Cell. 2015. PMID: 25728769 Free PMC article.
28 results