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72 results

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Page 1
Relevance of Half-Life in Drug Design.
Smith DA, Beaumont K, Maurer TS, Di L. Smith DA, et al. J Med Chem. 2018 May 24;61(10):4273-4282. doi: 10.1021/acs.jmedchem.7b00969. Epub 2017 Nov 17. J Med Chem. 2018. PMID: 29112446
Clearance in Drug Design.
Smith DA, Beaumont K, Maurer TS, Di L. Smith DA, et al. J Med Chem. 2019 Mar 14;62(5):2245-2255. doi: 10.1021/acs.jmedchem.8b01263. Epub 2018 Oct 17. J Med Chem. 2019. PMID: 30281973 Review.
Why do metabolites circulate?
Smith DA, Dalvie D. Smith DA, et al. Xenobiotica. 2012 Jan;42(1):107-26. doi: 10.3109/00498254.2011.630110. Epub 2011 Nov 24. Xenobiotica. 2012. PMID: 22115420 Review.
Free Drug Concepts: A Lingering Problem in Drug Discovery.
Webborn PJH, Beaumont K, Martin IJ, Smith DA. Webborn PJH, et al. Among authors: smith da. J Med Chem. 2025 Apr 10;68(7):6850-6856. doi: 10.1021/acs.jmedchem.5c00725. Epub 2025 Mar 21. J Med Chem. 2025. PMID: 40116772 No abstract available.
Importance of target-mediated drug disposition for small molecules.
Smith DA, van Waterschoot RAB, Parrott NJ, Olivares-Morales A, Lavé T, Rowland M. Smith DA, et al. Drug Discov Today. 2018 Dec;23(12):2023-2030. doi: 10.1016/j.drudis.2018.06.010. Epub 2018 Jun 19. Drug Discov Today. 2018. PMID: 29928850 Review.
Volume of Distribution in Drug Design.
Smith DA, Beaumont K, Maurer TS, Di L. Smith DA, et al. J Med Chem. 2015 Aug 13;58(15):5691-8. doi: 10.1021/acs.jmedchem.5b00201. Epub 2015 Apr 1. J Med Chem. 2015. PMID: 25799158
Do prodrugs deliver?
Smith DA. Smith DA. Curr Opin Drug Discov Devel. 2007 Sep;10(5):550-9. Curr Opin Drug Discov Devel. 2007. PMID: 17786853 Review.
Which metabolites circulate?
Loi CM, Smith DA, Dalvie D. Loi CM, et al. Among authors: smith da. Drug Metab Dispos. 2013 May;41(5):933-51. doi: 10.1124/dmd.112.050278. Epub 2013 Mar 1. Drug Metab Dispos. 2013. PMID: 23454828
72 results