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Induction of autophagy by spermidine promotes longevity.

Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Eisenberg T, et al. Among authors: deszcz l. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4. Nat Cell Biol. 2009. PMID: 19801973

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The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains.

Rodriguez Carvajal A, Grishkovskaya I, Gomez Diaz C, Vogel A, Sonn-Segev A, Kushwah MS, Schodl K, Deszcz L, Orban-Nemeth Z, Sakamoto S, Mechtler K, Kukura P, Clausen T, Haselbach D, Ikeda F. Rodriguez Carvajal A, et al. Among authors: deszcz l. Elife. 2021 Jun 18;10:e60660. doi: 10.7554/eLife.60660. Elife. 2021. PMID: 34142657 Free PMC article.

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An antiviral peptide inhibitor that is active against picornavirus 2A proteinases but not cellular caspases.

Deszcz L, Cencic R, Sousa C, Kuechler E, Skern T. Deszcz L, et al. J Virol. 2006 Oct;80(19):9619-27. doi: 10.1128/JVI.00612-06. J Virol. 2006. PMID: 16973565 Free PMC article.

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HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.

Grabarczyk DB, Petrova OA, Deszcz L, Kurzbauer R, Murphy P, Ahel J, Vogel A, Gogova R, Faas V, Kordic D, Schleiffer A, Meinhart A, Imre R, Lehner A, Neuhold J, Bader G, Stolt-Bergner P, Böttcher J, Wolkerstorfer B, Fischer G, Grishkovskaya I, Haselbach D, Kessler D, Clausen T. Grabarczyk DB, et al. Among authors: deszcz l. Nat Chem Biol. 2021 Oct;17(10):1084-1092. doi: 10.1038/s41589-021-00831-5. Epub 2021 Jul 22. Nat Chem Biol. 2021. PMID: 34294896 Free PMC article.

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The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains.

Gomez-Diaz C, Jonsson G, Schodl K, Deszcz L, Bestehorn A, Eislmayr K, Almagro J, Kavirayani A, Seida M, Fennell LM, Hagelkruys A, Kovarik P, Penninger JM, Ikeda F. Gomez-Diaz C, et al. Among authors: deszcz l. iScience. 2021 Oct 8;24(11):103241. doi: 10.1016/j.isci.2021.103241. eCollection 2021 Nov 19. iScience. 2021. PMID: 34755089 Free PMC article.

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The IAP family member BRUCE regulates autophagosome-lysosome fusion.

Ebner P, Poetsch I, Deszcz L, Hoffmann T, Zuber J, Ikeda F. Ebner P, et al. Among authors: deszcz l. Nat Commun. 2018 Feb 9;9(1):599. doi: 10.1038/s41467-018-02823-x. Nat Commun. 2018. PMID: 29426817 Free PMC article.

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Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.

Fennell LM, Gomez Diaz C, Deszcz L, Kavirayani A, Hoffmann D, Yanagitani K, Schleiffer A, Mechtler K, Hagelkruys A, Penninger J, Ikeda F. Fennell LM, et al. Among authors: deszcz l. EMBO J. 2020 Dec 15;39(24):e103303. doi: 10.15252/embj.2019103303. Epub 2020 Nov 20. EMBO J. 2020. PMID: 33215740 Free PMC article.

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Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.

Hellerschmied D, Lehner A, Franicevic N, Arnese R, Johnson C, Vogel A, Meinhart A, Kurzbauer R, Deszcz L, Gazda L, Geeves M, Clausen T. Hellerschmied D, et al. Among authors: deszcz l. Nat Commun. 2019 Oct 21;10(1):4781. doi: 10.1038/s41467-019-12667-8. Nat Commun. 2019. PMID: 31636255 Free PMC article.

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Arginine phosphorylation marks proteins for degradation by a Clp protease.

Trentini DB, Suskiewicz MJ, Heuck A, Kurzbauer R, Deszcz L, Mechtler K, Clausen T. Trentini DB, et al. Among authors: deszcz l. Nature. 2016 Nov 3;539(7627):48-53. doi: 10.1038/nature20122. Epub 2016 Oct 6. Nature. 2016. PMID: 27749819 Free PMC article.

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Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.

Asaoka T, Almagro J, Ehrhardt C, Tsai I, Schleiffer A, Deszcz L, Junttila S, Ringrose L, Mechtler K, Kavirayani A, Gyenesei A, Hofmann K, Duchek P, Rittinger K, Ikeda F. Asaoka T, et al. Among authors: deszcz l. EMBO Rep. 2016 Nov;17(11):1624-1640. doi: 10.15252/embr.201642378. Epub 2016 Oct 4. EMBO Rep. 2016. PMID: 27702987 Free PMC article.

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