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Decay of Skin-Specific Gene Modules in Pangolins.
Pinto B, Valente R, Caramelo F, Ruivo R, Castro LFC. Pinto B, et al. J Mol Evol. 2023 Aug;91(4):458-470. doi: 10.1007/s00239-023-10118-z. Epub 2023 May 30. J Mol Evol. 2023. PMID: 37249590 Free PMC article.
We show that genes driving wax monoester formation, Awat1/2, show patterns of inactivation in the stem pangolin branch, while the triacylglycerol synthesis gene Dgat2l6 seems independently eroded in the African and Asian clades. ...
We show that genes driving wax monoester formation, Awat1/2, show patterns of inactivation in the stem pangolin branch, while the triacylgly …
Complete Inactivation of Sebum-Producing Genes Parallels the Loss of Sebaceous Glands in Cetacea.
Lopes-Marques M, Machado AM, Alves LQ, Fonseca MM, Barbosa S, Sinding MS, Rasmussen MH, Iversen MR, Frost Bertelsen M, Campos PF, da Fonseca R, Ruivo R, Castro LFC. Lopes-Marques M, et al. Mol Biol Evol. 2019 Jun 1;36(6):1270-1280. doi: 10.1093/molbev/msz068. Mol Biol Evol. 2019. PMID: 30895322 Free PMC article.
We investigated the evolution of the key molecular components responsible for skin sebum production: Dgat2l6, Awat1, Awat2, Elovl3, Mogat3, and Fabp9. We show that all analyzed genes have been rendered nonfunctional in Cetacea species (toothed and baleen whales). ...
We investigated the evolution of the key molecular components responsible for skin sebum production: Dgat2l6, Awat1, Awat2, Elovl3, M …
Comparative genomics and proteomics of vertebrate diacylglycerol acyltransferase (DGAT), acyl CoA wax alcohol acyltransferase (AWAT) and monoacylglycerol acyltransferase (MGAT).
Holmes RS. Holmes RS. Comp Biochem Physiol Part D Genomics Proteomics. 2010 Mar;5(1):45-54. doi: 10.1016/j.cbd.2009.09.004. Epub 2009 Oct 2. Comp Biochem Physiol Part D Genomics Proteomics. 2010. PMID: 20374941 Free article.
Evidence is reported for 8 opossum monoacylglycerol acyltransferase-like (MGAT) (E.C. 2.3.1.22) and diacylglycerol acyltransferase-like (DGAT) (E.C. 2.3.1.20) genes and proteins, including DGAT1, DGAT2, DGAT2L6 (DGAT2-like protein 6), AWAT1 (acyl CoA wax alcohol acyltransf …
Evidence is reported for 8 opossum monoacylglycerol acyltransferase-like (MGAT) (E.C. 2.3.1.22) and diacylglycerol acyltransferase-like (DGA …