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CB2 Cannabinoid receptors as a therapeutic target-what does the future hold?

Dhopeshwarkar A, Mackie K. Dhopeshwarkar A, et al. Mol Pharmacol. 2014 Oct;86(4):430-7. doi: 10.1124/mol.114.094649. Epub 2014 Aug 8. Mol Pharmacol. 2014. PMID: 25106425 Free PMC article. Review.

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Evidence for a GPR18 Role in Chemotaxis, Proliferation, and the Course of Wound Closure in the Cornea.

Murataeva N, Daily L, Taylor X, Dhopeshwarkar A, Hu SS, Miller S, McHugh D, Oehler O, Li S, Bonanno JA, Mackie K, Straiker A. Murataeva N, et al. Among authors: dhopeshwarkar a. Cornea. 2019 Jul;38(7):905-913. doi: 10.1097/ICO.0000000000001934. Cornea. 2019. PMID: 30969262 Free PMC article.

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Cannabinoid-induced chemotaxis in bovine corneal epithelial cells.

Murataeva N, Li S, Oehler O, Miller S, Dhopeshwarkar A, Hu SS, Bonanno JA, Bradshaw H, Mackie K, McHugh D, Straiker A. Murataeva N, et al. Among authors: dhopeshwarkar a. Invest Ophthalmol Vis Sci. 2015 May;56(5):3304-13. doi: 10.1167/iovs.14-15675. Invest Ophthalmol Vis Sci. 2015. PMID: 26024113 Free PMC article.

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Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing.

Murataeva N, Miller S, Dhopeshwarkar A, Leishman E, Daily L, Taylor X, Morton B, Lashmet M, Bradshaw H, Hillard CJ, Romero J, Straiker A. Murataeva N, et al. Among authors: dhopeshwarkar a. Exp Eye Res. 2019 May;182:74-84. doi: 10.1016/j.exer.2019.03.011. Epub 2019 Mar 21. Exp Eye Res. 2019. PMID: 30905716 Free PMC article.

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Synthesis of Photoswitchable Δ⁹-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling.

Westphal MV, Schafroth MA, Sarott RC, Imhof MA, Bold CP, Leippe P, Dhopeshwarkar A, Grandner JM, Katritch V, Mackie K, Trauner D, Carreira EM, Frank JA. Westphal MV, et al. Among authors: dhopeshwarkar a. J Am Chem Soc. 2017 Dec 20;139(50):18206-18212. doi: 10.1021/jacs.7b06456. Epub 2017 Dec 12. J Am Chem Soc. 2017. PMID: 29161035

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Slowly Signaling G Protein-Biased CB₂ Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence.

Lin X, Dhopeshwarkar AS, Huibregtse M, Mackie K, Hohmann AG. Lin X, et al. Among authors: dhopeshwarkar as. Mol Pharmacol. 2018 Feb;93(2):49-62. doi: 10.1124/mol.117.109355. Epub 2017 Nov 30. Mol Pharmacol. 2018. PMID: 29192123 Free PMC article.

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Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway.

Dhopeshwarkar A, Mackie K. Dhopeshwarkar A, et al. J Pharmacol Exp Ther. 2016 Aug;358(2):342-51. doi: 10.1124/jpet.116.232561. Epub 2016 May 18. J Pharmacol Exp Ther. 2016. PMID: 27194477 Free PMC article.

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Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists.

Dhopeshwarkar A, Murataeva N, Makriyannis A, Straiker A, Mackie K. Dhopeshwarkar A, et al. J Pharmacol Exp Ther. 2017 Feb;360(2):300-311. doi: 10.1124/jpet.116.236539. Epub 2016 Dec 7. J Pharmacol Exp Ther. 2017. PMID: 27927913 Free PMC article.

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Where's my entourage? The curious case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol.

Murataeva N, Dhopeshwarkar A, Yin D, Mitjavila J, Bradshaw H, Straiker A, Mackie K. Murataeva N, et al. Among authors: dhopeshwarkar a. Pharmacol Res. 2016 Aug;110:173-180. doi: 10.1016/j.phrs.2016.04.015. Epub 2016 Apr 23. Pharmacol Res. 2016. PMID: 27117667 Free PMC article.

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Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal.

Li AL, Lin X, Dhopeshwarkar AS, Thomaz AC, Carey LM, Liu Y, Nikas SP, Makriyannis A, Mackie K, Hohmann AG. Li AL, et al. Among authors: dhopeshwarkar as. Mol Pharmacol. 2019 Feb;95(2):155-168. doi: 10.1124/mol.118.113233. Epub 2018 Nov 30. Mol Pharmacol. 2019. PMID: 30504240 Free PMC article.

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