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2008 2
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123 results

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Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15.
Zhu H, Li M, Bi D, Yang H, Gao Y, Song F, Zheng J, Xie R, Zhang Y, Liu H, Yan X, Kong C, Zhu Y, Xu Q, Wei Q, Qin H. Zhu H, et al. Nat Commun. 2024 Feb 24;15(1):1688. doi: 10.1038/s41467-024-45572-w. Nat Commun. 2024. PMID: 38402201 Free PMC article.
F. nucleatum invades intestinal epithelial cells and binds to DHX15, a protein of RNA helicase family expressed on CRC tumor cells, mechanistically involving ERK/STAT3 signaling. Knock out of Dhx15 in Villin-Cre/Kras(G12D+/-) mice attenuates the CRC phenotype. These …
F. nucleatum invades intestinal epithelial cells and binds to DHX15, a protein of RNA helicase family expressed on CRC tumor cells, m …
DHX15 and Rig-I Coordinate Apoptosis and Innate Immune Signaling by Antiviral RNase L.
Ramnani B, Devale T, Manivannan P, Haridas A, Malathi K. Ramnani B, et al. Viruses. 2024 Dec 13;16(12):1913. doi: 10.3390/v16121913. Viruses. 2024. PMID: 39772220 Free PMC article.
In RNase L-activated cells, DHX15 interacts with Rig-I and MAVS, and cells lacking MAVS expression were resistant to apoptosis. ...The RNA binding of both DHX15 and Rig-I is required for apoptosis induction, and the expression of both single proteins in cells lackin …
In RNase L-activated cells, DHX15 interacts with Rig-I and MAVS, and cells lacking MAVS expression were resistant to apoptosis. ...Th …
Dhx15 regulates zebrafish intestinal development through the Wnt signaling pathway.
Yao J, Cai Y, Chen Z, Wang X, Lai X, Pan L, Li Y, Wang S. Yao J, et al. Genomics. 2023 Mar;115(2):110578. doi: 10.1016/j.ygeno.2023.110578. Epub 2023 Feb 10. Genomics. 2023. PMID: 36775210 Free article.
DEAH-box helicase 15 (DHX15) is ATP-dependent RNA helicase which is known for its role in RNA metabolism. Recent studies reported DHX15 involves in the intestinal immunity. ...We found the profound intestinal defects in dhx15 knockout zebrafish. Decreased pro …
DEAH-box helicase 15 (DHX15) is ATP-dependent RNA helicase which is known for its role in RNA metabolism. Recent studies reported …
DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer.
Zhang J, Huang J, Xu K, Xing P, Huang Y, Liu Z, Tong L, Manley JL. Zhang J, et al. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2216712119. doi: 10.1073/pnas.2216712119. Epub 2022 Dec 2. Proc Natl Acad Sci U S A. 2022. PMID: 36459648 Free PMC article.
Here, using a variety of protein-protein interaction assays, we identify DHX15 as the critical helicase. We further show that depletion of DHX15 or expression of any of several DHX15 mutants, including one implicated in acute myeloid leukemia, partially recap …
Here, using a variety of protein-protein interaction assays, we identify DHX15 as the critical helicase. We further show that depleti …
DHX15 inhibits mouse APOBEC3 deamination.
Zhao W, Modak A, Ross SR. Zhao W, et al. PLoS Pathog. 2025 Apr 1;21(4):e1013045. doi: 10.1371/journal.ppat.1013045. eCollection 2025 Apr. PLoS Pathog. 2025. PMID: 40168451 Free PMC article.
In this study, we found that the dead box helicase DHX15 interacts with mouse APOBEC3 and inhibits its deamination activity. DHX15 was packaged into murine leukemia virus (MLV) virions independent of its binding with APOBEC3. Moreover, DHX15 knockdown inhibit …
In this study, we found that the dead box helicase DHX15 interacts with mouse APOBEC3 and inhibits its deamination activity. DHX15 …
DHX15 is required to control RNA virus-induced intestinal inflammation.
Xing J, Zhou X, Fang M, Zhang E, Minze LJ, Zhang Z. Xing J, et al. Cell Rep. 2021 Jun 22;35(12):109205. doi: 10.1016/j.celrep.2021.109205. Cell Rep. 2021. PMID: 34161762 Free PMC article.
Importantly, we generate IEC-specific Dhx15-knockout mice and demonstrate that DHX15 is required for controlling intestinal inflammation induced by enteric RNA virus rotavirus in suckling mice and reovirus in adult mice in vivo, which owes to impaired IFN-beta, IFN- …
Importantly, we generate IEC-specific Dhx15-knockout mice and demonstrate that DHX15 is required for controlling intestinal in …
DHX15 Inhibits Autophagy and the Proliferation of Hepatoma Cells.
Zhao M, Ying L, Wang R, Yao J, Zhu L, Zheng M, Chen Z, Yang Z. Zhao M, et al. Front Med (Lausanne). 2021 Feb 11;7:591736. doi: 10.3389/fmed.2020.591736. eCollection 2020. Front Med (Lausanne). 2021. PMID: 33644083 Free PMC article.
In this study, we discovered a non-classic function of DHX15 and identified DHX15 as a suppressive protein in autophagy for the first time. We further found that mTORC1 is involved in DHX15-mediated regulation of autophagy and that DHX15 inhibits proli …
In this study, we discovered a non-classic function of DHX15 and identified DHX15 as a suppressive protein in autophagy for th …
RNA helicase DHX15 exemplifies a unique dependency in acute leukemia.
Guo H, Xu J, Xing P, Li Q, Wang D, Tang C, Palhais B, Roels J, Liu J, Pan S, Huang J, Liu Z, Zhu P, Taghon T, Qing G, Van Vlierberghe P, Liu H. Guo H, et al. Haematologica. 2023 Aug 1;108(8):2029-2043. doi: 10.3324/haematol.2022.282066. Haematologica. 2023. PMID: 36861414 Free PMC article.
Functional analysis using multiple murine T-ALL models demonstrates the essential importance of DHX15 in tumor cell survival and leukemogenesis. Moreover, single-cell transcriptomics reveals that DHX15 depletion in T-cell progenitors hinders burst proliferation duri …
Functional analysis using multiple murine T-ALL models demonstrates the essential importance of DHX15 in tumor cell survival and leuk …
Dhx15 regulates zebrafish definitive hematopoiesis through the unfolded protein response pathway.
Cai Y, Wang J, Jin D, Liu Q, Chen X, Pan L, Li Y, Wang X, Qian F, Wang J, Zhong TP, Wang S. Cai Y, et al. Cancer Sci. 2021 Sep;112(9):3884-3894. doi: 10.1111/cas.15002. Epub 2021 Jul 11. Cancer Sci. 2021. PMID: 34077586 Free PMC article.
Our previous work reported a DEAH box helicase 15 (DHX15) R222G mutation in AML patients, and we showed DHX15 overexpression is associated with poor prognosis in AML patients. ...The study of DHX15 and DHX15 R222G mutation could hold clinical significa …
Our previous work reported a DEAH box helicase 15 (DHX15) R222G mutation in AML patients, and we showed DHX15 overexpression i …
Relationship between DHX15 expression and survival in colorectal cancer.
Fan L, Guo X, Zhang J, Wang Y, Wang J, Li Y. Fan L, et al. Rev Esp Enferm Dig. 2023 May;115(5):234-240. doi: 10.17235/reed.2022.8838/2022. Rev Esp Enferm Dig. 2023. PMID: 36177832 Free article.
RESULTS: low expression of DHX15 mRNA and DHX15 protein in CRC were both negative factors for survival. Overall survival of patients with low-expression of DHX15 was significantly lower (chi2 = 8.452, p = 0.004) by Kaplan-Meier evaluation. ...CONCLUSION: our …
RESULTS: low expression of DHX15 mRNA and DHX15 protein in CRC were both negative factors for survival. Overall survival of pa …
123 results