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26 results

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Page 1
DHX34 as a promising biomarker for prognosis, immunotherapy and chemotherapy in Pan-Cancer: A Comprehensive Analysis and Experimental Validation.
Liu N, Wang Q, Zhu P, He G, Li Z, Chen T, Yuan J, La T, Tian H, Li Z. Liu N, et al. J Cancer. 2024 Oct 28;15(20):6594-6615. doi: 10.7150/jca.102230. eCollection 2024. J Cancer. 2024. PMID: 39668816 Free PMC article.
Among cervical cancers, DHX34 mutation frequency was the highest. Intriguingly, a positive correlation was observed between DHX34 expression and Mutational Burden (TMB) across 12 tumor types, and Microsatellite Instability (MSI) across 10 tumor types. ...Conclusions …
Among cervical cancers, DHX34 mutation frequency was the highest. Intriguingly, a positive correlation was observed between DHX34 …
DHX34 deficiency triggers tumor-intrinsic immunity via a dsRNA-mediated type I interferon pathway activation in HCC.
Zhang C, Huang L, Li Z, Wang Q, Liu N, Zhang C, Liu X, Zhang C, He G, Sun J, Li Z, Tian H. Zhang C, et al. Neoplasia. 2025 Sep;67:101198. doi: 10.1016/j.neo.2025.101198. Epub 2025 Jun 30. Neoplasia. 2025. PMID: 40592235 Free PMC article.
However, the effect of DHX34 in regulating the immunogenicity in hepatocellular carcinoma (HCC) is still unclear. Here, a surprising function of DHX34 in inhibited HCC immunogenicity is identified. DHX34-deficient tumors were infiltrated by activated T cells …
However, the effect of DHX34 in regulating the immunogenicity in hepatocellular carcinoma (HCC) is still unclear. Here, a surprising …
Environmental cadmium exposure promotes lung cancer via DHX34: A molecular toxicology perspective.
Lu Y, Kong W, Wang K, Shao Z, Hui X, Song X, Zhang S, Ma L, Cheng Z, Su F, Zhang T, Yang K. Lu Y, et al. Ecotoxicol Environ Saf. 2025 Oct 1;304:119087. doi: 10.1016/j.ecoenv.2025.119087. Epub 2025 Sep 19. Ecotoxicol Environ Saf. 2025. PMID: 40974667 Free article.
LASSO regression and Mendelian randomization suggested a causal role of DHX34 in lung cancer. Molecular docking demonstrated a strong binding affinity between Cd(2 +) and DHX34 (binding free energy = -5.34 kcal/mol), and molecular dynamics simulations confirmed the …
LASSO regression and Mendelian randomization suggested a causal role of DHX34 in lung cancer. Molecular docking demonstrated a strong …
Macrophage DHX34 as a negative regulator of the CX3CL1-CX3CR1 axis and CD8(+) T-cell infiltration in hepatocellular carcinoma.
Li Z, Yuan J, Du F, Liu N, Zhang C, Huang L, Feng J, Zhang C, Liu X, Sun J, He G, Liu G, Li Z, Tian H. Li Z, et al. Int Immunopharmacol. 2026 Jan 15;169:116014. doi: 10.1016/j.intimp.2025.116014. Epub 2025 Dec 13. Int Immunopharmacol. 2026. PMID: 41389669
We therefore examined the impact of macrophage DHX34 on T-cell trafficking and tumor control. METHODS: We profiled DHX34 expression and subcellular distribution across human single-cell RNA-sequencing datasets and confirmed its pattern in murine TAMs. ...Targeting …
We therefore examined the impact of macrophage DHX34 on T-cell trafficking and tumor control. METHODS: We profiled DHX34 expre …
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants.
Rio-Machin A, Vulliamy T, Hug N, Walne A, Tawana K, Cardoso S, Ellison A, Pontikos N, Wang J, Tummala H, Al Seraihi AFH, Alnajar J, Bewicke-Copley F, Armes H, Barnett M, Bloor A, Bödör C, Bowen D, Fenaux P, Green A, Hallahan A, Hjorth-Hansen H, Hossain U, Killick S, Lawson S, Layton M, Male AM, Marsh J, Mehta P, Mous R, Nomdedéu JF, Owen C, Pavlu J, Payne EM, Protheroe RE, Preudhomme C, Pujol-Moix N, Renneville A, Russell N, Saggar A, Sciuccati G, Taussig D, Toze CL, Uyttebroeck A, Vandenberghe P, Schlegelberger B, Ripperger T, Steinemann D, Wu J, Mason J, Page P, Akiki S, Reay K, Cavenagh JD, Plagnol V, Caceres JF, Fitzgibbon J, Dokal I. Rio-Machin A, et al. Nat Commun. 2020 Feb 25;11(1):1044. doi: 10.1038/s41467-020-14829-5. Nat Commun. 2020. PMID: 32098966 Free PMC article.
Whole exome sequencing in a further 37 uncharacterized families (43%) allowed us to rationalize 65 new candidate loci, including genes mutated in rare hematological syndromes (ADA, GP6, IL17RA, PRF1 and SEC23B), reported in prior MDS/AML or inherited bone marrow failure series (D …
Whole exome sequencing in a further 37 uncharacterized families (43%) allowed us to rationalize 65 new candidate loci, including genes mutat …
The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.
Melero R, Hug N, López-Perrote A, Yamashita A, Cáceres JF, Llorca O. Melero R, et al. Nat Commun. 2016 Feb 4;7:10585. doi: 10.1038/ncomms10585. Nat Commun. 2016. PMID: 26841701 Free PMC article.
DHX34 comprises two distinct structural units, a core that binds UPF1 and a protruding carboxy-terminal domain (CTD) that binds the SMG1 kinase, as shown using truncated forms of DHX34 and electron microscopy of the SMG1-DHX34 complex. Truncation of the DH …
DHX34 comprises two distinct structural units, a core that binds UPF1 and a protruding carboxy-terminal domain (CTD) that binds the S …
A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.
Hug N, Aitken S, Longman D, Raab M, Armes H, Mann AR, Rio-Machin A, Fitzgibbon J, Rouault-Pierre K, Cáceres JF. Hug N, et al. RNA. 2022 Sep;28(9):1224-1238. doi: 10.1261/rna.079277.122. Epub 2022 Jun 29. RNA. 2022. PMID: 35768279 Free PMC article.
Here, we show that DHX34 is also associated with the human spliceosomal catalytic C complex. Mapping of DHX34 endogenous binding sites using cross-linking immunoprecipitation (CLIP) revealed that DHX34 is preferentially associated with pre-mRNAs and locates a …
Here, we show that DHX34 is also associated with the human spliceosomal catalytic C complex. Mapping of DHX34 endogenous bindi …
Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish.
Anastasaki C, Longman D, Capper A, Patton EE, Cáceres JF. Anastasaki C, et al. Nucleic Acids Res. 2011 May;39(9):3686-94. doi: 10.1093/nar/gkq1319. Epub 2011 Jan 11. Nucleic Acids Res. 2011. PMID: 21227923 Free PMC article.
A genome-wide RNAi screen in C. elegans resulted in the identification of two novel NMD genes that are essential for proper embryonic development. Their human orthologues, DHX34 and NAG/NBAS, are required for NMD in human cells. Here, we find that the zebrafish genome enco …
A genome-wide RNAi screen in C. elegans resulted in the identification of two novel NMD genes that are essential for proper embryonic develo …
Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM.
López-Perrote A, Hug N, González-Corpas A, Rodríguez CF, Serna M, García-Martín C, Boskovic J, Fernandez-Leiro R, Caceres JF, Llorca O. López-Perrote A, et al. Elife. 2020 Nov 18;9:e63042. doi: 10.7554/eLife.63042. Elife. 2020. PMID: 33205750 Free PMC article.
Cryo-EM reveals that DHX34 induces extensive changes in the N-termini of every RUVBL2 subunit in the complex, stabilizing a conformation that does not bind nucleotide and thereby down-regulates ATP hydrolysis of the complex. Using ATPase-deficient mutants, we find that …
Cryo-EM reveals that DHX34 induces extensive changes in the N-termini of every RUVBL2 subunit in the complex, stabilizing a conformat …
DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans.
Longman D, Hug N, Keith M, Anastasaki C, Patton EE, Grimes G, Cáceres JF. Longman D, et al. Nucleic Acids Res. 2013 Sep;41(17):8319-31. doi: 10.1093/nar/gkt585. Epub 2013 Jul 4. Nucleic Acids Res. 2013. PMID: 23828042 Free PMC article.
Interestingly, transcripts encoding different NMD factors were sensitive to DHX34 and NBAS depletion, suggesting that these factors participate in a conserved NMD negative feedback regulatory loop, as was recently described for core NMD factors. In summary, we find that …
Interestingly, transcripts encoding different NMD factors were sensitive to DHX34 and NBAS depletion, suggesting that these factors p …
26 results