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Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain.

Bogie JFJ, Grajchen E, Wouters E, Corrales AG, Dierckx T, Vanherle S, Mailleux J, Gervois P, Wolfs E, Dehairs J, Van Broeckhoven J, Bowman AP, Lambrichts I, Gustafsson JÅ, Remaley AT, Mulder M, Swinnen JV, Haidar M, Ellis SR, Ntambi JM, Zelcer N, Hendriks JJA. Bogie JFJ, et al. Among authors: dierckx t. J Exp Med. 2020 May 4;217(5):e20191660. doi: 10.1084/jem.20191660. J Exp Med. 2020. PMID: 32097464 Free PMC article.

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CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation.

Grajchen E, Wouters E, van de Haterd B, Haidar M, Hardonnière K, Dierckx T, Van Broeckhoven J, Erens C, Hendrix S, Kerdine-Römer S, Hendriks JJA, Bogie JFJ. Grajchen E, et al. Among authors: dierckx t. J Neuroinflammation. 2020 Jul 27;17(1):224. doi: 10.1186/s12974-020-01899-x. J Neuroinflammation. 2020. PMID: 32718316 Free PMC article.

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The Impact of Phytosterols on the Healthy and Diseased Brain.

Dierckx T, Bogie JFJ, Hendriks JJA. Dierckx T, et al. Curr Med Chem. 2019;26(37):6750-6765. doi: 10.2174/0929867325666180706113844. Curr Med Chem. 2019. PMID: 29984647 Review.

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Altered PPARγ Expression Promotes Myelin-Induced Foam Cell Formation in Macrophages in Multiple Sclerosis.

Wouters E, Grajchen E, Jorissen W, Dierckx T, Wetzels S, Loix M, Tulleners MP, Staels B, Stinissen P, Haidar M, Bogie JFJ, Hendriks JJA. Wouters E, et al. Among authors: dierckx t. Int J Mol Sci. 2020 Dec 7;21(23):9329. doi: 10.3390/ijms21239329. Int J Mol Sci. 2020. PMID: 33297574 Free PMC article.

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An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans.

Delgobo M, Mendes DA, Kozlova E, Rocha EL, Rodrigues-Luiz GF, Mascarin L, Dias G, Patrício DO, Dierckx T, Bicca MA, Bretton G, Tenório de Menezes YK, Starick MR, Rovaris D, Del Moral J, Mansur DS, Van Weyenbergh J, Báfica A. Delgobo M, et al. Among authors: dierckx t. Elife. 2019 Oct 22;8:e47013. doi: 10.7554/eLife.47013. Elife. 2019. PMID: 31637998 Free PMC article.

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enAsCas12a Enables CRISPR-Directed Evolution to Screen for Functional Drug Resistance Mutations in Sequences Inaccessible to SpCas9.

Neggers JE, Jacquemyn M, Dierckx T, Kleinstiver BP, Thibaut HJ, Daelemans D. Neggers JE, et al. Among authors: dierckx t. Mol Ther. 2021 Jan 6;29(1):208-224. doi: 10.1016/j.ymthe.2020.09.025. Epub 2020 Sep 20. Mol Ther. 2021. PMID: 33002419 Free article.

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A genetic IFN/STAT1/FAS axis determines CD4 T stem cell memory levels and apoptosis in healthy controls and Adult T-cell Leukemia patients.

Khouri R, Silva-Santos G, Dierckx T, Menezes SM, Decanine D, Theys K, Silva AC, Farré L, Bittencourt A, Mangino M, Roederer M, Vandamme AM, Van Weyenbergh J. Khouri R, et al. Among authors: dierckx t. Oncoimmunology. 2018 Feb 13;7(5):e1426423. doi: 10.1080/2162402X.2018.1426423. eCollection 2018. Oncoimmunology. 2018. PMID: 29721391 Free PMC article.

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GlycA, a Nuclear Magnetic Resonance Spectroscopy Measure for Protein Glycosylation, is a Viable Biomarker for Disease Activity in IBD.

Dierckx T, Verstockt B, Vermeire S, van Weyenbergh J. Dierckx T, et al. J Crohns Colitis. 2019 Mar 26;13(3):389-394. doi: 10.1093/ecco-jcc/jjy162. J Crohns Colitis. 2019. PMID: 30312386 Free PMC article.

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Serum GlycA Level is Elevated in Active Systemic Lupus Erythematosus and Correlates to Disease Activity and Lupus Nephritis Severity.

Dierckx T, Chiche L, Daniel L, Lauwerys B, Weyenbergh JV, Jourde-Chiche N. Dierckx T, et al. J Clin Med. 2020 Mar 31;9(4):970. doi: 10.3390/jcm9040970. J Clin Med. 2020. PMID: 32244481 Free PMC article.

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ISG15-Induced IL-10 Is a Novel Anti-Inflammatory Myeloid Axis Disrupted during Active Tuberculosis.

Dos Santos PF, Van Weyenbergh J, Delgobo M, Oliveira Patricio D, Ferguson BJ, Guabiraba R, Dierckx T, Menezes SM, Báfica A, Mansur DS. Dos Santos PF, et al. Among authors: dierckx t. J Immunol. 2018 Feb 15;200(4):1434-1442. doi: 10.4049/jimmunol.1701120. Epub 2018 Jan 8. J Immunol. 2018. PMID: 29311364 Free article.

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