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63 results

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Page 1
Smoking and tetramer tryptase accelerate intervertebral disc degeneration by inducing METTL14-mediated DIXDC1 m(6) modification.
Tu J, Li W, Hansbro PM, Yan Q, Bai X, Donovan C, Kim RY, Galvao I, Das A, Yang C, Zou J, Diwan A. Tu J, et al. Mol Ther. 2023 Aug 2;31(8):2524-2542. doi: 10.1016/j.ymthe.2023.06.010. Epub 2023 Jun 19. Mol Ther. 2023. PMID: 37340635 Free PMC article.
TTs were found to regulate the expression of methyltransferase 14 (METTL14) at the epigenetic level by inducing N6-methyladenosine (m(6)A) deposition in the 3' untranslated region (UTR) of the transcript that encodes dishevelled-axin (DIX) domain-containing 1 (DIXDC1). Tha …
TTs were found to regulate the expression of methyltransferase 14 (METTL14) at the epigenetic level by inducing N6-methyladenosine (m(6)A) d …
DIXDC1 activates the Wnt signaling pathway and promotes gastric cancer cell invasion and metastasis.
Tan C, Qiao F, Wei P, Chi Y, Wang W, Ni S, Wang Q, Chen T, Sheng W, Du X, Wang L. Tan C, et al. Mol Carcinog. 2016 Apr;55(4):397-408. doi: 10.1002/mc.22290. Epub 2015 Feb 3. Mol Carcinog. 2016. PMID: 25648220
As a positive regulator of the Wnt/beta-catenin pathway, the biological role of DIXDC1 in human gastric cancer and the relationship between DIXDC1 and the Wnt pathway are unclear. ...DIXDC1 enhanced beta-catenin nuclear accumulation, which activated the Wnt p …
As a positive regulator of the Wnt/beta-catenin pathway, the biological role of DIXDC1 in human gastric cancer and the relationship b …
DIX domain containing 1 (DIXDC1) modulates VEGFR2 level in vasculatures to regulate embryonic and postnatal retina angiogenesis.
Kim Y, Kim DY, Zhang H, Bae CR, Seong D, Kim Y, Song J, Kim YM, Kwon YG. Kim Y, et al. BMC Biol. 2022 Feb 10;20(1):41. doi: 10.1186/s12915-022-01240-3. BMC Biol. 2022. PMID: 35144597 Free PMC article.
DIXDC1 knockdown inhibited VEGF-induced angiogenesis in endothelial cells in vitro by downregulating VEGFR2 expression. ...These results suggest that DIXDC1 is an important factor in developmental and pathological angiogenesis. CONCLUSION: We have identified DIXD …
DIXDC1 knockdown inhibited VEGF-induced angiogenesis in endothelial cells in vitro by downregulating VEGFR2 expression. ...These resu …
DIXDC1 promotes the growth of acute myeloid leukemia cells by upregulating the Wnt/beta-catenin signaling pathway.
Xin H, Li C, Wang M. Xin H, et al. Biomed Pharmacother. 2018 Nov;107:1548-1555. doi: 10.1016/j.biopha.2018.08.144. Epub 2018 Sep 5. Biomed Pharmacother. 2018. PMID: 30257373
Accumulating evidence suggests that dysregulation of Dishevelled-Axin domain-containing 1 (DIXDC1) is involved in the progression and development of various cancers. However, little is known about the relevance of DIXDC1 in acute myeloid leukemia (AML). ...In additi …
Accumulating evidence suggests that dysregulation of Dishevelled-Axin domain-containing 1 (DIXDC1) is involved in the progression and …
DIXDC1 promotes retinoic acid-induced neuronal differentiation and inhibits gliogenesis in P19 cells.
Jing XT, Wu HT, Wu Y, Ma X, Liu SH, Wu YR, Ding XF, Peng XZ, Qiang BQ, Yuan JG, Fan WH, Fan M. Jing XT, et al. Cell Mol Neurobiol. 2009 Feb;29(1):55-67. doi: 10.1007/s10571-008-9295-9. Epub 2008 Jul 16. Cell Mol Neurobiol. 2009. PMID: 18629627 Free PMC article.
Human DIXDC1 is a member of Dishevelled-Axin (DIX) domain containing gene family which plays important roles in Wnt signaling and neural development. ...Thus, our finding suggested that DIXDC1 might play an important role during neurogenesis, overexpression of DI …
Human DIXDC1 is a member of Dishevelled-Axin (DIX) domain containing gene family which plays important roles in Wnt signaling and neu …
DIXDC1 promotes tumor proliferation and cell adhesion mediated drug resistance (CAM-DR) via enhancing p-Akt in Non-Hodgkin's lymphomas.
Ouyang Y, Zhong F, Wang Q, Ding L, Zhang P, Chen L, Wang Y, Cheng C. Ouyang Y, et al. Leuk Res. 2016 Nov;50:104-111. doi: 10.1016/j.leukres.2016.09.011. Epub 2016 Sep 8. Leuk Res. 2016. PMID: 27701018
DIX domain containing 1 (DIXDC1), is a human homolog of Ccd1, a DIX domain containing protein in zebrafish. The present study was undertaken to determine the expression and biologic function of DIXDC1 in Non-Hodgkin's lymphoma (NHL). ...Adhesion to fibronectin (FN) …
DIX domain containing 1 (DIXDC1), is a human homolog of Ccd1, a DIX domain containing protein in zebrafish. The present study was und …
DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants.
Kwan V, Meka DP, White SH, Hung CL, Holzapfel NT, Walker S, Murtaza N, Unda BK, Schwanke B, Yuen RKC, Habing K, Milsom C, Hope KJ, Truant R, Scherer SW, Calderon de Anda F, Singh KK. Kwan V, et al. Cell Rep. 2016 Nov 8;17(7):1892-1904. doi: 10.1016/j.celrep.2016.10.047. Cell Rep. 2016. PMID: 27829159 Free article.
Using a knockout mouse model, we determined that DIXDC1 is a regulator of excitatory neuron dendrite development and synapse function in the cortex. ...Finally, rare missense variants in DIXDC1 were identified in ASD patient cohorts via genetic sequencing. Interesti …
Using a knockout mouse model, we determined that DIXDC1 is a regulator of excitatory neuron dendrite development and synapse function …
DIXDC1 prevents oxygen-glucose deprivation/reoxygenation-induced injury in hippocampal neurons in vitro by promoting Wnt/beta-catenin signaling.
Li T, Wan YC, Sun LJ, Tao SJ, Chen P, Liu CH, Wang K, Zhou CY, Zhao GQ. Li T, et al. Eur Rev Med Pharmacol Sci. 2018 Sep;22(17):5678-5687. doi: 10.26355/eurrev_201809_15835. Eur Rev Med Pharmacol Sci. 2018. PMID: 30229845 Free article.
However, whether DIXDC1 plays a role during cerebral ischemia/reperfusion injury remains unknown. In this study, we investigated the potential role of DIXDC1 in neuronal injury induced by oxygen-glucose deprivation and reoxygenation (OGD/R), an in vitro model of cer …
However, whether DIXDC1 plays a role during cerebral ischemia/reperfusion injury remains unknown. In this study, we investigated the …
Dixdc1 targets CyclinD1 and p21 via PI3K pathway activation to promote Schwann cell proliferation after sciatic nerve crush.
Wu W, Liu Q, Liu Y, Yu Z, Wang Y. Wu W, et al. Biochem Biophys Res Commun. 2016 Sep 16;478(2):956-63. doi: 10.1016/j.bbrc.2016.08.058. Epub 2016 Aug 10. Biochem Biophys Res Commun. 2016. PMID: 27521891
First of all, we detected SNC-induced increased levels of Dixdc1 in Schwann cells and interestingly identified parallel expression of PCNA (proliferation cell nuclear antigen) with Dixdc1. Besides, we observed up-regulated Dixdc1 during the process of TNF-alp …
First of all, we detected SNC-induced increased levels of Dixdc1 in Schwann cells and interestingly identified parallel expression of …
Proteomic Analysis Reveals Autism-Associated Gene DIXDC1 Regulates Proteins Associated with Mitochondrial Organization and Function.
Kwan V, Rosa E, Xing S, Murtaza N, Singh K, Holzapfel NT, Berg T, Lu Y, Singh KK. Kwan V, et al. J Proteome Res. 2021 Jan 1;20(1):1052-1062. doi: 10.1021/acs.jproteome.0c00896. Epub 2020 Dec 18. J Proteome Res. 2021. PMID: 33337894
However, the prediction of these signaling pathways is primarily based on the structure of Dixdc1. Given the role of Dixdc1 in neural development and brain disorders, we hypothesized that Dixdc1 may regulate additional signaling pathways in the brain. ...In c …
However, the prediction of these signaling pathways is primarily based on the structure of Dixdc1. Given the role of Dixdc1 in …
63 results