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138 results

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Page 1
Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer.
Wang X, Cheng H, Zhao J, Li J, Chen Y, Cui K, Tian L, Zhang J, Li C, Sun S, Feng Y, Yao S, Bian Z, Huang S, Fei B, Huang Z. Wang X, et al. Mol Cancer. 2022 Nov 14;21(1):210. doi: 10.1186/s12943-022-01675-w. Mol Cancer. 2022. PMID: 36376892 Free PMC article.
However, the functions and mechanisms of most lncRNAs in colorectal cancer (CRC) remain unclear. METHODS: The expression of DLGAP1-AS2 was assessed by quantitative RT-PCR in multiple CRC cohorts. The impacts of DLGAP1-AS2 on CRC growth and metastasis were evaluated …
However, the functions and mechanisms of most lncRNAs in colorectal cancer (CRC) remain unclear. METHODS: The expression of DLGAP1-AS …
DLGAP1-AS2 promotes human colorectal cancer progression through trans-activation of Myc.
Ren C, Han H, Pan J, Chang Q, Wang W, Guo X, Bian J. Ren C, et al. Mamm Genome. 2022 Dec;33(4):672-683. doi: 10.1007/s00335-022-09963-y. Epub 2022 Oct 12. Mamm Genome. 2022. PMID: 36222892
Further, through the screening of a series of signal pathways, we found that Myc pathway was involved in the effect of DLGAP1-AS2. Silencing of DLGAP1-AS2 markedly reduced Myc mRNA and protein levels. Blockade of Myc effectively abolished the enhanced aggressive beh …
Further, through the screening of a series of signal pathways, we found that Myc pathway was involved in the effect of DLGAP1-AS2. Si …
DLGAP1-AS2 promotes estrogen receptor signalling and confers tamoxifen resistance in breast cancer.
Liang X, Zhao Y, Fang Z, Shao N, Zhai D, Zhang M, Yu L, Shi Y. Liang X, et al. Mol Biol Rep. 2022 May;49(5):3939-3947. doi: 10.1007/s11033-022-07244-0. Epub 2022 Apr 21. Mol Biol Rep. 2022. PMID: 35449318
However, the mechanisms of tamoxifen resistance remain unclear. METHODS: The expression of lncRNA DLGAP1 antisense RNA 2 (DLGAP1-AS2) was detected by qPCR. The effect of DLGAP1-AS2 on tamoxifen resistance was evaluated by MTT, colony formation, TUNEL and flow …
However, the mechanisms of tamoxifen resistance remain unclear. METHODS: The expression of lncRNA DLGAP1 antisense RNA 2 (DLGAP1 …
Long Non-coding RNA DLGAP1-AS1 and DLGAP1-AS2: Two Novel Oncogenes in Multiple Cancers.
Zhao F, Tan F, Tang L, Du Z, Chen X, Yang Y, Zhou G, Yuan C. Zhao F, et al. Curr Med Chem. 2023;30(25):2822-2834. doi: 10.2174/0929867329666220919114919. Curr Med Chem. 2023. PMID: 36121088 Review.
This review elucidates the pathophysiological functions of lncRNA DLGAP1-AS1 and lncRNA DLGAP1-AS2 in a variety of tumors. METHODS: Via systematic analysis and in-depth study about relevant articles in PubMed, this article analyzes and summarizes the mechanism of an …
This review elucidates the pathophysiological functions of lncRNA DLGAP1-AS1 and lncRNA DLGAP1-AS2 in a variety of tumors. MET …
LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression.
Miao W, Li N, Gu B, Yi G, Su Z, Cheng H. Miao W, et al. J Biochem. 2020 Apr 1;167(4):411-418. doi: 10.1093/jb/mvz108. J Biochem. 2020. PMID: 31899508
LncRNA DLGAP1 antisense RNA 2 (DLGAP1-AS2) is one kind cytoplasmic long non-coding RNA; however, there is rarely little information about its function in physiological process. ...Furthermore, knockdown of DLGAP1-AS2 inhibited the growth of xenograft glioma t …
LncRNA DLGAP1 antisense RNA 2 (DLGAP1-AS2) is one kind cytoplasmic long non-coding RNA; however, there is rarely little inform …
DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Chemoresistance in Squamous Cell Carcinoma.
Nan Y, Luo Q, Wu X, Liu S, Zhao P, Chang W, Zhou A, Liu Z. Nan Y, et al. Cancer Res. 2022 Aug 16;82(16):2887-2903. doi: 10.1158/0008-5472.CAN-22-0717. Cancer Res. 2022. PMID: 35731019
To identify chemoresistance mechanisms and to explore novel targets for chemosensitization, we performed whole-transcriptome sequencing of paired resistant and parental SCC cells. We identified DLGAP1 antisense RNA 2 (D-AS2) as a crucial noncoding RNA that contributes to c …
To identify chemoresistance mechanisms and to explore novel targets for chemosensitization, we performed whole-transcriptome sequencing of p …
METTL3-induced DLGAP1-AS2 promotes non-small cell lung cancer tumorigenesis through m(6)A/c-Myc-dependent aerobic glycolysis.
Zhang Q, Zhang Y, Chen H, Sun LN, Zhang B, Yue DS, Wang CL, Zhang ZF. Zhang Q, et al. Cell Cycle. 2022 Dec;21(24):2602-2614. doi: 10.1080/15384101.2022.2105885. Epub 2022 Aug 16. Cell Cycle. 2022. PMID: 35972892 Free PMC article.
Here, this work focused on the functions and molecular mechanism of m(6)A-modified lncRNA DLGAP1 antisense RNA 2 (DLGAP1-AS2) in NSCLC. Microarray analysis found that lncRNA DLGAP1-AS2 is upregulated in NSCLC cells. ...Functionally, DLGAP1-AS2 overexpr …
Here, this work focused on the functions and molecular mechanism of m(6)A-modified lncRNA DLGAP1 antisense RNA 2 (DLGAP1-AS2) …
LncRNA DLGAP1-AS2 regulates miR-503/cyclin D1 to promote cell proliferation in non-small cell lung cancer.
Wang L, Tang L, Ge T, Zhu F, Liu D, Guo H, Qian P, Xu N. Wang L, et al. BMC Pulm Med. 2021 Aug 28;21(1):277. doi: 10.1186/s12890-021-01633-0. BMC Pulm Med. 2021. PMID: 34454450 Free PMC article.
This study aimed to study the role of DLGAP1-AS2 in non-small cell lung cancer (NSCLC). METHODS: Expression of DLGAP1-AS2 in NSCLC and paired non-tumor tissues from 64 NSCLC patients and the prognostic value of DLGAP1-AS2 for NSCLC were analyzed by performing …
This study aimed to study the role of DLGAP1-AS2 in non-small cell lung cancer (NSCLC). METHODS: Expression of DLGAP1-AS2 in N …
LncRNA DLGAP1-AS1 accelerates glioblastoma cell proliferation through targeting miR-515-5p/ROCK1/NFE2L1 axis and activating Wnt signaling pathway.
Wang Z, Han Y, Li Q, Wang B, Ma J. Wang Z, et al. Brain Behav. 2021 Oct;11(10):e2321. doi: 10.1002/brb3.2321. Epub 2021 Sep 18. Brain Behav. 2021. PMID: 34536977 Free PMC article.
However, the function and mechanism of lncRNA DLGAP1 antisense RNA 1 (DLGAP1-AS1) in GBM remain still unknown. METHODS: DLGAP1-AS1 expression in GBM cells was detected by RT-qPCR. ...DLGAP1-AS1 depletion inhibited cell proliferation, but induced apopto …
However, the function and mechanism of lncRNA DLGAP1 antisense RNA 1 (DLGAP1-AS1) in GBM remain still unknown. METHODS: DLG …
LncRNA DLGAP1-AS2 overexpression associates with gastric tumorigenesis: a promising diagnostic and therapeutic target.
Soltani R, Amini M, Mazaheri Moghaddam M, Jebelli A, Ahmadiyan S, Bidar N, Baradaran B, MotieGhader H, Asadi M, Mokhtarzadeh A. Soltani R, et al. Mol Biol Rep. 2022 Jul;49(7):6817-6826. doi: 10.1007/s11033-021-07038-w. Epub 2022 Jan 4. Mol Biol Rep. 2022. PMID: 34981339
METHODS AND RESULTS: The expression level of DLGAP1-AS2 was initially pre-evaluated in GC datasets from Gene Expression Omnibus (GEO). ...Moreover, ROC curve analysis showed the high accuracy of the DLGAP1-AS2 expression pattern as a diagnostic biomarker for GC. CON …
METHODS AND RESULTS: The expression level of DLGAP1-AS2 was initially pre-evaluated in GC datasets from Gene Expression Omnibus (GEO) …
138 results