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Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence.
Meng W, Sjöholm LK, Kononenko O, Tay N, Zhang D, Sarkisyan D, Geske JR, Ing A, Qiu W, Watanabe H, Almamoun R, Frieling H, Bleich S, Cui D, Biernacka JM, Mayfield RD, Dang Y, Karpyak VM, Schumann G; IMAGEN Consortium; Bakalkin G, Ekström TJ, Rüegg J, Liu Y. Meng W, et al. Mol Psychiatry. 2021 Aug;26(8):4367-4382. doi: 10.1038/s41380-019-0588-9. Epub 2019 Nov 19. Mol Psychiatry. 2021. PMID: 31745236
Methylation at the DMR-DLGAP2 regulated expression of DLGAP2 in vitro, and Dlgap2-deficient mice showed reduced alcohol consumption compared with wild-type controls. These results suggest that DLGAP2 may be an interface for genetic and epigenetic facto …
Methylation at the DMR-DLGAP2 regulated expression of DLGAP2 in vitro, and Dlgap2-deficient mice showed reduced alcohol …
DNA Methylation Near DLGAP2 May Mediate the Relationship between Family History of Type 1 Diabetes and Type 1 Diabetes Risk.
Johnson RK, Ireton AJ, Carry PM, Vanderlinden LA, Dong F, Romero A, Johnson DR, Ghosh D, Yang F, Frohnert B, Yang IV, Kechris K, Rewers M, Norris JM. Johnson RK, et al. Pediatr Diabetes. 2023;2023:5367637. doi: 10.1155/2023/5367637. Epub 2023 Sep 11. Pediatr Diabetes. 2023. PMID: 38765731 Free PMC article.
Given the differential risk of type 1 diabetes (T1D) in offspring of affected fathers versus affected mothers and our observation that T1D cases have differential DNA methylation near the imprinted DLGAP2 gene compared to controls, we examined whether methylation near D …
Given the differential risk of type 1 diabetes (T1D) in offspring of affected fathers versus affected mothers and our observation that T1D c …
DNA methylation at DLGAP2 and risk for relapse in alcohol dependence during acamprosate treatment.
Özel F, Di Criscio M, Lupu DI, Sarkisyan D, Hlady RA, Robertson KD, Bakalkin G, Liu Y, Biernacka JM, Karpyak VM, Ekström TJ, Rüegg J. Özel F, et al. Drug Alcohol Depend. 2024 Mar 1;256:111116. doi: 10.1016/j.drugalcdep.2024.111116. Epub 2024 Feb 3. Drug Alcohol Depend. 2024. PMID: 38364647 Free article.
We have previously shown that methylation in the DLGAP2 gene, coding for a synaptic density protein, is associated with alcohol dependence. ...This is in line with our previous findings showing that DLGAP2 methylation is lower in alcohol dependent subjects compared …
We have previously shown that methylation in the DLGAP2 gene, coding for a synaptic density protein, is associated with alcohol depen …
Altered odor perception in Dlgap2 mutant mice, a mouse model of autism spectrum disorder.
Chen YF, Tsao CY, Chen YT, Chang HC, Li WY, Chiang JL, Chen CF, Chen CH, Gau SS, Lee KY, Lee LJ, Wang YC. Chen YF, et al. Behav Brain Res. 2025 Mar 5;480:115365. doi: 10.1016/j.bbr.2024.115365. Epub 2024 Dec 2. Behav Brain Res. 2025. PMID: 39631506
A microdeletion at the 8p23 terminal regions of chromosome 8p23 was identified in a Taiwanese patient with ASD, suggesting a potential association with mutations in the DLGAP2 gene. DLGAP2 is expressed in the olfactory bulb in rodents. The current study investigated …
A microdeletion at the 8p23 terminal regions of chromosome 8p23 was identified in a Taiwanese patient with ASD, suggesting a potential assoc …
Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia.
Ouellette AR, Neuner SM, Dumitrescu L, Anderson LC, Gatti DM, Mahoney ER, Bubier JA, Churchill G, Peters L, Huentelman MJ, Herskowitz JH, Yang HS, Smith AN, Reitz C, Kunkle BW, White CC, De Jager PL, Schneider JA, Bennett DA, Seyfried NT; Alzheimer’s Disease Genetics Consortium; Chesler EJ, Hadad N, Hohman TJ, Kaczorowski CC. Ouellette AR, et al. Cell Rep. 2020 Sep 1;32(9):108091. doi: 10.1016/j.celrep.2020.108091. Cell Rep. 2020. PMID: 32877673 Free PMC article.
We find an association between Dlgap2 and AD phenotypes at the variant, gene and protein expression, and methylation levels. Lower cortical DLGAP2 expression is observed in AD and is associated with more plaques and tangles at autopsy and faster cognitive decline. . …
We find an association between Dlgap2 and AD phenotypes at the variant, gene and protein expression, and methylation levels. Lower co …
Altered synaptic protein expression, aberrant spine morphology, and impaired spatial memory in Dlgap2 mutant mice, a genetic model of autism spectrum disorder.
Hsieh MY, Tuan LH, Chang HC, Wang YC, Chen CH, Shy HT, Lee LJ, Gau SS. Hsieh MY, et al. Cereb Cortex. 2023 Apr 4;33(8):4779-4793. doi: 10.1093/cercor/bhac379. Cereb Cortex. 2023. PMID: 36169576
DLGAP2 protein was detected in the hippocampus yet abolished in homozygous Dlgap2 knockout (Dlgap2 KO) mice. In this study, we characterized the hippocampal phenotypes in Dlgap2 mutant mice. Dlgap2 KO mice exhibited impaired spatial memory, indi …
DLGAP2 protein was detected in the hippocampus yet abolished in homozygous Dlgap2 knockout (Dlgap2 KO) mice. In this st …
Evaluation of hippocampal DLGAP2 overexpression on cognition, synaptic function, and dendritic spine structure in a translationally relevant AD mouse model.
Ouellette A, O'Connell K, Kaczorowski C. Ouellette A, et al. Alzheimers Dement. 2025 Oct;21(10):e70728. doi: 10.1002/alz.70728. Alzheimers Dement. 2025. PMID: 41025221 Free PMC article.
HIGHLIGHTS: DLGAP2 overexpression accelerates AD-related impairment of contextual fear acquisition and memory. DLGAP2 overexpression impairs synaptic plasticity prior to AD-related memory impairment, but not intrinsic excitability. ...
HIGHLIGHTS: DLGAP2 overexpression accelerates AD-related impairment of contextual fear acquisition and memory. DLGAP2 overexpr …
8p23.2-pter Microdeletions: Seven New Cases Narrowing the Candidate Region and Review of the Literature.
Catusi I, Garzo M, Capra AP, Briuglia S, Baldo C, Canevini MP, Cantone R, Elia F, Forzano F, Galesi O, Grosso E, Malacarne M, Peron A, Romano C, Saccani M, Larizza L, Recalcati MP. Catusi I, et al. Genes (Basel). 2021 Apr 27;12(5):652. doi: 10.3390/genes12050652. Genes (Basel). 2021. PMID: 33925474 Free PMC article.
Overall, our data favor the hypothesis that DLGAP2 is the actual strongest candidate for neurodevelopmental/behavioral phenotypes. Additional patients will be necessary to validate the pathogenic role of DLGAP2 and better define how the two contiguous genes, ARHGEF1 …
Overall, our data favor the hypothesis that DLGAP2 is the actual strongest candidate for neurodevelopmental/behavioral phenotypes. Ad …
Role of the DLGAP2 gene encoding the SAP90/PSD-95-associated protein 2 in schizophrenia.
Li JM, Lu CL, Cheng MC, Luu SU, Hsu SH, Hu TM, Tsai HY, Chen CH. Li JM, et al. PLoS One. 2014 Jan 8;9(1):e85373. doi: 10.1371/journal.pone.0085373. eCollection 2014. PLoS One. 2014. PMID: 24416398 Free PMC article.
This study aimed to investigate whether the DLGAP2 gene is associated with schizophrenia. We resequenced the putative promoter region and all the exons of the DLGAP2 gene in 523 patients with schizophrenia and 596 non-psychotic controls from Taiwan and conducted a c …
This study aimed to investigate whether the DLGAP2 gene is associated with schizophrenia. We resequenced the putative promoter region …
Evaluation of hippocampal DLGAP2 overexpression on cognition, synaptic function, and dendritic spine structure in a translationally relevant AD mouse model.
Ouellette A, O'Connell K, Kaczorowski C. Ouellette A, et al. bioRxiv [Preprint]. 2025 May 14:2025.05.13.653830. doi: 10.1101/2025.05.13.653830. bioRxiv. 2025. Update in: Alzheimers Dement. 2025 Oct;21(10):e70728. doi: 10.1002/alz.70728. PMID: 40462999 Free PMC article. Updated. Preprint.
INTRODUCTION: Developing effective therapeutics for Alzheimer's Disease (AD) requires a better understanding of the molecular drivers of the disease. Our previous work nominated DLGAP2 as a modifier of age-related cognitive decline and risk for AD. We tested the hypothesis …
INTRODUCTION: Developing effective therapeutics for Alzheimer's Disease (AD) requires a better understanding of the molecular drivers of the …
60 results