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1997 1
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DNASE1L2, as a Carcinogenic Marker, Affects the Phenotype of Breast Cancer Cells Via Regulating Epithelial-Mesenchymal Transition Process.
Liu CR, Meng FH. Liu CR, et al. Cancer Biother Radiopharm. 2021 Mar;36(2):180-188. doi: 10.1089/cbr.2019.3504. Epub 2020 Apr 24. Cancer Biother Radiopharm. 2021. PMID: 32343605
Cox regression models were implemented for analyzing the potential prognosticators of BC. Small interference RNA-DNASE1L2 and pcDNA3.1-DNASE1L2 were transfected into BC cells to silence and overexpress DNASE1L2, respectively. ...Besides, high expression of …
Cox regression models were implemented for analyzing the potential prognosticators of BC. Small interference RNA-DNASE1L2 and pcDNA3. …
Actin-Resistant DNase1L2 as a Potential Therapeutics for CF Lung Disease.
Delfino D, Mori G, Rivetti C, Grigoletto A, Bizzotto G, Cavozzi C, Malatesta M, Cavazzini D, Pasut G, Percudani R. Delfino D, et al. Biomolecules. 2021 Mar 10;11(3):410. doi: 10.3390/biom11030410. Biomolecules. 2021. PMID: 33802146 Free PMC article.
However, the marked susceptibility to actin inhibition of this enzyme prompts the research of alternative treatments that could overcome this limitation. Within the human DNase repertoire, DNase1L2 is ideally suited for this purpose because it exhibits metal-dependent endo …
However, the marked susceptibility to actin inhibition of this enzyme prompts the research of alternative treatments that could overcome thi …
DNase1L2 suppresses biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus.
Eckhart L, Fischer H, Barken KB, Tolker-Nielsen T, Tschachler E. Eckhart L, et al. Br J Dermatol. 2007 Jun;156(6):1342-5. doi: 10.1111/j.1365-2133.2007.07886.x. Epub 2007 Apr 25. Br J Dermatol. 2007. PMID: 17459041
METHODS: DNase1L2 was extracted from normal human stratum corneum, immunocaptured and incubated with plasmid DNA. ...RESULTS: DNase1L2 was found to be present in an enzymatically active form in the stratum corneum of human skin. ...
METHODS: DNase1L2 was extracted from normal human stratum corneum, immunocaptured and incubated with plasmid DNA. ...RESULTS: DNas …
DNase1L2 degrades nuclear DNA during corneocyte formation.
Fischer H, Eckhart L, Mildner M, Jaeger K, Buchberger M, Ghannadan M, Tschachler E. Fischer H, et al. J Invest Dermatol. 2007 Jan;127(1):24-30. doi: 10.1038/sj.jid.5700503. Epub 2006 Aug 10. J Invest Dermatol. 2007. PMID: 16902420 Free article.
In biopsies of normal skin, DNase1L2 mRNA was regularly found in suprabasal KC and DNase1L2 protein was highly abundant in the stratum granulosum. In contrast to normal skin, DNase1L2 expression was downregulated in parakeratotic epidermis such as in psoriati …
In biopsies of normal skin, DNase1L2 mRNA was regularly found in suprabasal KC and DNase1L2 protein was highly abundant in the …
Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis.
Fischer H, Buchberger M, Napirei M, Tschachler E, Eckhart L. Fischer H, et al. Sci Rep. 2017 Jul 25;7(1):6433. doi: 10.1038/s41598-017-06652-8. Sci Rep. 2017. PMID: 28743926 Free PMC article.
The DNA within DNase1L2/DNase2-deficient corneocytes was partially degraded in a DNase1-independent manner. ...Parakeratosis was not associated with altered corneocyte resistance to mechanical stress, changes in transepidermal water loss, or inflammatory infiltrates in …
The DNA within DNase1L2/DNase2-deficient corneocytes was partially degraded in a DNase1-independent manner. ...Parakeratosis was not …
Origin and significance of the human DNase repertoire.
Mori G, Delfino D, Pibiri P, Rivetti C, Percudani R. Mori G, et al. Sci Rep. 2022 Jun 20;12(1):10364. doi: 10.1038/s41598-022-14133-w. Sci Rep. 2022. PMID: 35725583 Free PMC article.
DNase1, DNase1L1, and DNase1L3 co-existed in jawless fish, whereas DNase1L2 originated in amniotes by tandem duplication of DNase1. Among the non-human DNases, DNase1L4 and newly identified DNase1L5 derived from early duplications that were lost in terrestrial vertebrates. …
DNase1, DNase1L1, and DNase1L3 co-existed in jawless fish, whereas DNase1L2 originated in amniotes by tandem duplication of DNase1. A …
Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.
Manils J, Fischer H, Climent J, Casas E, García-Martínez C, Bas J, Sukseree S, Vavouri T, Ciruela F, de Anta JM, Tschachler E, Eckhart L, Soler C. Manils J, et al. Sci Rep. 2017 Sep 19;7(1):11902. doi: 10.1038/s41598-017-12308-4. Sci Rep. 2017. PMID: 28928425 Free PMC article.
The cornification of keratinocytes on the surface of skin and oral epithelia is associated with the degradation of nuclear DNA. The endonuclease DNase1L2 and the exonuclease Trex2 are expressed specifically in cornifying keratinocytes. Deletion of DNase1L2 causes re …
The cornification of keratinocytes on the surface of skin and oral epithelia is associated with the degradation of nuclear DNA. The endonucl …
Essential role of the keratinocyte-specific endonuclease DNase1L2 in the removal of nuclear DNA from hair and nails.
Fischer H, Szabo S, Scherz J, Jaeger K, Rossiter H, Buchberger M, Ghannadan M, Hermann M, Theussl HC, Tobin DJ, Wagner EF, Tschachler E, Eckhart L. Fischer H, et al. J Invest Dermatol. 2011 Jun;131(6):1208-15. doi: 10.1038/jid.2011.13. Epub 2011 Feb 10. J Invest Dermatol. 2011. PMID: 21307874 Free PMC article.
Targeted deletion of the keratinocyte-specific endonuclease DNase1-like 2 (DNase1L2) in the mouse resulted in the aberrant retention of DNA in hair and nails, as well as in epithelia of the tongue and the esophagus. In contrast to our previous studies in human keratinocyte …
Targeted deletion of the keratinocyte-specific endonuclease DNase1-like 2 (DNase1L2) in the mouse resulted in the aberrant retention …
Terminal differentiation of nail matrix keratinocytes involves up-regulation of DNase1L2 but is independent of caspase-14 expression.
Jäger K, Fischer H, Tschachler E, Eckhart L. Jäger K, et al. Differentiation. 2007 Dec;75(10):939-46. doi: 10.1111/j.1432-0436.2007.00183.x. Epub 2007 May 9. Differentiation. 2007. PMID: 17490414
Nail matrix keratinocytes lacked processed caspase-3, a marker of apoptosis, and did not express caspase-14, a protease up-regulated during terminal differentiation of epidermal keratinocytes. By contrast, DNase1L2, which is also up-regulated during the differentiation of …
Nail matrix keratinocytes lacked processed caspase-3, a marker of apoptosis, and did not express caspase-14, a protease up-regulated during …
Transcriptional differences between vesicular hand eczema and atopic dermatitis.
Rosenberg FM, Wardenaar R, Voorberg AN, Spierings DCJ, Schuttelaar MA. Rosenberg FM, et al. Contact Dermatitis. 2024 Jan;90(1):23-31. doi: 10.1111/cod.14442. Epub 2023 Oct 19. Contact Dermatitis. 2024. PMID: 37857578
Interferon signalling and necroptosis were significantly more prominent in VHE compared to AD. Downregulated genes identified only in VHE (like DNASE1L2, KRT2, KRT9 and KRT25) indicate an aberrant epidermal differentiation. ...
Interferon signalling and necroptosis were significantly more prominent in VHE compared to AD. Downregulated genes identified only in VHE (l …
25 results