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115 results

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Page 1
Tumour-associated macrophage-derived DOCK7-enriched extracellular vesicles drive tumour metastasis in colorectal cancer via the RAC1/ABCA1 axis.
Chen W, Zhou M, Guan B, Xie B, Liu Y, He J, Zhao J, Zhao Q, Yan D. Chen W, et al. Clin Transl Med. 2024 Feb;14(2):e1591. doi: 10.1002/ctm2.1591. Clin Transl Med. 2024. PMID: 38385857 Free PMC article.
CONCLUSIONS: Overall, our findings suggest that DOCK7 delivered via TAM-EVs could regulate cholesterol metabolism in CRC cells and CRC cell metastasis through the RAC1/AKT/FOXO1/ABCA1 axis. DOCK7 could thus be a new therapeutic target for controlling CRC metastasis. …
CONCLUSIONS: Overall, our findings suggest that DOCK7 delivered via TAM-EVs could regulate cholesterol metabolism in CRC cells and CR …
DOCK7 protects against replication stress by promoting RPA stability on chromatin.
Gao M, Guo G, Huang J, Hou X, Ham H, Kim W, Zhao F, Tu X, Zhou Q, Zhang C, Zhu Q, Liu J, Yan Y, Xu Z, Yin P, Luo K, Weroha J, Deng M, Billadeau DD, Lou Z. Gao M, et al. Nucleic Acids Res. 2021 Apr 6;49(6):3322-3337. doi: 10.1093/nar/gkab134. Nucleic Acids Res. 2021. PMID: 33704464 Free PMC article.
DOCK7 is phosphorylated by ATR and then recruited by MDC1 to the chromatin and replication fork during replication stress. ...Moreover, DOCK7 is overexpressed in ovarian cancer and depleting DOCK7 sensitizes cancer cells to camptothecin. ...
DOCK7 is phosphorylated by ATR and then recruited by MDC1 to the chromatin and replication fork during replication stress. ...Moreove …
A planar polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia.
Menin L, Weber J, Villa S, Martini E, Maspero E, Niño CA, Cancila V, Poli A, Maiuri P, Palamidessi A, Frittoli E, Bianchi F, Tripodo C, Walters KJ, Giavazzi F, Scita G, Polo S. Menin L, et al. Cell Rep. 2023 Aug 29;42(8):113001. doi: 10.1016/j.celrep.2023.113001. Epub 2023 Aug 16. Cell Rep. 2023. PMID: 37590133 Free PMC article.
While the upstream RAC1 regulators in individual migratory cells or leader cells during invasion or wound healing are well characterized, how RAC1 is controlled in follower cells remains unknown. Here, we identify a MYO6-DOCK7 axis essential for spatially restricting RAC1 …
While the upstream RAC1 regulators in individual migratory cells or leader cells during invasion or wound healing are well characterized, ho …
A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia.
Menin L, Weber J, Villa S, Martini E, Maspero E, Cancila V, Maiuri P, Palamidessi A, Frittoli E, Bianchi F, Tripodo C, Walters KJ, Giavazzi F, Scita G, Polo S. Menin L, et al. bioRxiv [Preprint]. 2023 Jan 23:2023.01.23.524898. doi: 10.1101/2023.01.23.524898. bioRxiv. 2023. Update in: Cell Rep. 2023 Aug 29;42(8):113001. doi: 10.1016/j.celrep.2023.113001. PMID: 36747801 Free PMC article. Updated. Preprint.
The MYO6-DOCK7 axis specifically controls the extension of cryptic lamellipodia required to drive tissue fluidification and cooperative mode motion in otherwise solid and static carcinoma cell collectives. HIGHLIGHTS: Collective motion of jammed epithelia requires myosin V …
The MYO6-DOCK7 axis specifically controls the extension of cryptic lamellipodia required to drive tissue fluidification and cooperati …
DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.
Yang YT, Wang CL, Van Aelst L. Yang YT, et al. Nat Neurosci. 2012 Sep;15(9):1201-10. doi: 10.1038/nn.3171. Epub 2012 Jul 29. Nat Neurosci. 2012. PMID: 22842144 Free PMC article.
In contrast, DOCK7 overexpression promotes RGC differentiation to basal progenitors and neurons. We further present evidence that DOCK7 influences neurogenesis by controlling apically directed interkinetic nuclear migration of RGCs. DOCK7 exerts its effects b …
In contrast, DOCK7 overexpression promotes RGC differentiation to basal progenitors and neurons. We further present evidence that …
The Interaction between the DOCK7 Protein and the E2 Protein of Classical Swine Fever Virus Is Not Involved with Viral Replication or Pathogenicity.
Vuono E, Ramirez-Medina E, Silva E, Berggren K, Rai A, Espinoza N, Borca MV, Gladue DP. Vuono E, et al. Viruses. 2023 Dec 30;16(1):70. doi: 10.3390/v16010070. Viruses. 2023. PMID: 38257770 Free PMC article.
Using the yeast two-hybrid system, we have previously shown that CSFV E2 specifically interacts with the (DOCK7) dedicator of cytokinesis, a scaffolding protein. In this report, the interaction between E2 and DOCK7 was evaluated. ...Therefore, interaction between CS …
Using the yeast two-hybrid system, we have previously shown that CSFV E2 specifically interacts with the (DOCK7) dedicator of cytokin …
Dock7: a GEF for Rho-family GTPases and a novel myosin VI-binding partner in neuronal PC12 cells.
Majewski Ł, Sobczak M, Havrylov S, Jóźwiak J, Rędowicz MJ. Majewski Ł, et al. Biochem Cell Biol. 2012 Aug;90(4):565-74. doi: 10.1139/o2012-009. Epub 2012 Apr 4. Biochem Cell Biol. 2012. PMID: 22475431
MVI-Dock7 interaction was further confirmed by co-immunoprecipitation of endogenous MVI complexed with Dock7. In addition, MVI and Dock7 colocalized in interphase and dividing cells. We conclude that in PC12 cells MVI-Dock7 complexes may function at di …
MVI-Dock7 interaction was further confirmed by co-immunoprecipitation of endogenous MVI complexed with Dock7. In addition, MVI …
Nbeal2 interacts with Dock7, Sec16a, and Vac14.
Mayer L, Jasztal M, Pardo M, Aguera de Haro S, Collins J, Bariana TK, Smethurst PA, Grassi L, Petersen R, Nurden P, Favier R, Yu L, Meacham S, Astle WJ, Choudhary J, Yue WW, Ouwehand WH, Guerrero JA. Mayer L, et al. Blood. 2018 Mar 1;131(9):1000-1011. doi: 10.1182/blood-2017-08-800359. Epub 2017 Nov 29. Blood. 2018. PMID: 29187380 Free PMC article.
We present here the interactome of Nbeal2 with additional validation by reverse immunoprecipitation of Dock7, Sec16a, and Vac14 as interactors of Nbeal2. We show that GPS-causing mutations in its BEACH domain have profound and possible effects on the interaction with Do …
We present here the interactome of Nbeal2 with additional validation by reverse immunoprecipitation of Dock7, Sec16a, and Vac14 as in …
Characteristic facial features and cortical blindness distinguish the DOCK7-related epileptic encephalopathy.
Haberlandt E, Valovka T, Janjic T, Müller T, Blatsios G, Karall D, Janecke AR. Haberlandt E, et al. Mol Genet Genomic Med. 2021 Mar;9(3):e1607. doi: 10.1002/mgg3.1607. Epub 2021 Jan 20. Mol Genet Genomic Med. 2021. PMID: 33471954 Free PMC article.
METHODS: We identified 23- and 27-year-old siblings with the clinical pattern reported for DOCK7 deficiency, and conducted genome-wide linkage analysis and WES. The consequences of a DOCK7 variant were analyzed on the transcript and protein level in patients' fibrob …
METHODS: We identified 23- and 27-year-old siblings with the clinical pattern reported for DOCK7 deficiency, and conducted genome-wid …
Homozygosity for a Novel DOCK7 Variant Due to Segmental Uniparental Isodisomy of Chromosome 1 Associated with Early Infantile Epileptic Encephalopathy (EIEE) and Cortical Visual Impairment.
Kivrak Pfiffner F, Koller S, Ménétrey A, Graf U, Bähr L, Maspoli A, Hackenberg A, Kottke R, Gerth-Kahlert C, Berger W. Kivrak Pfiffner F, et al. Int J Mol Sci. 2022 Jul 2;23(13):7382. doi: 10.3390/ijms23137382. Int J Mol Sci. 2022. PMID: 35806387 Free PMC article.
In WES data, the father was a noncarrier, and the mother was heterozygous for this DOCK7 variant. The DOCK7 gene is located in 1p31.3, a region situated in one of the four isodisomic segments of chromosome 1, explaining the homozygosity seen in the affected child. F …
In WES data, the father was a noncarrier, and the mother was heterozygous for this DOCK7 variant. The DOCK7 gene is located in …
115 results