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DOCK8 deficiency.
Su HC, Jing H, Zhang Q. Su HC, et al. Ann N Y Acad Sci. 2011 Dec;1246:26-33. doi: 10.1111/j.1749-6632.2011.06295.x. Ann N Y Acad Sci. 2011. PMID: 22236427 Review.
In this review, we relate the clinical features of this disease to studies using patients' cells and a mouse model of Dock8 deficiency, which have revealed how DOCK8 regulates T and B cell numbers and functions. The results of these studies help to explain how the a …
In this review, we relate the clinical features of this disease to studies using patients' cells and a mouse model of Dock8 deficienc …
DOCK8 regulates signal transduction events to control immunity.
Kearney CJ, Randall KL, Oliaro J. Kearney CJ, et al. Cell Mol Immunol. 2017 May;14(5):406-411. doi: 10.1038/cmi.2017.9. Epub 2017 Apr 3. Cell Mol Immunol. 2017. PMID: 28366940 Free PMC article. Review.
Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred to as DOCK8 deficiency. ...Early studies demonstrated that DOCK8 is required for lymphocyte survival, migration and immune sy …
Genetic mutations in the gene encoding DOCK8 cause an autosomal recessive form of hyper immunoglobulin E syndrome (AR-HIES), referred …
DOCK8 deficiency: Insights into pathophysiology, clinical features and management.
Biggs CM, Keles S, Chatila TA. Biggs CM, et al. Clin Immunol. 2017 Aug;181:75-82. doi: 10.1016/j.clim.2017.06.003. Epub 2017 Jun 15. Clin Immunol. 2017. PMID: 28625885 Free PMC article. Review.
DOCK8 deficiency impairs immune cell migration, function and survival, and it impacts both innate and adaptive immune responses. Clinically, DOCK8 deficiency is characterized by allergic inflammation as well as susceptibility towards infections, autoimmunity and mal …
DOCK8 deficiency impairs immune cell migration, function and survival, and it impacts both innate and adaptive immune responses. Clin …
Macabre T(H)2 skewing in DOCK8 deficiency.
Janssen E, Wilkie H, Geha RS. Janssen E, et al. J Allergy Clin Immunol. 2021 Jul;148(1):73-75. doi: 10.1016/j.jaci.2021.02.025. Epub 2021 Mar 2. J Allergy Clin Immunol. 2021. PMID: 33667480 No abstract available.
Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion.
Gutierrez-Ruiz OL, Johnson KM, Krueger EW, Nooren RE, Cruz-Reyes N, Heppelmann CJ, Hogenson TL, Fernandez-Zapico ME, McNiven MA, Razidlo GL. Gutierrez-Ruiz OL, et al. Cell Rep. 2023 Sep 26;42(9):113042. doi: 10.1016/j.celrep.2023.113042. Epub 2023 Aug 30. Cell Rep. 2023. PMID: 37651233 Free PMC article.
Using comparative proteomics, we found that oncogenic KRAS significantly enriches levels of the guanine nucleotide exchange factor (GEF) dedicator of cytokinesis 8 (DOCK8) on lysosomes. Surprisingly, DOCK8 is aberrantly expressed in a subset of PDAC, where it promot …
Using comparative proteomics, we found that oncogenic KRAS significantly enriches levels of the guanine nucleotide exchange factor (GEF) ded …
DOCK8 inhibits the immune function of neutrophils in sepsis by regulating aerobic glycolysis.
Zhu H, Xu J, Li K, Chen M, Wu Y, Zhang X, Chen H, Chen D. Zhu H, et al. Immun Inflamm Dis. 2023 Aug;11(8):e965. doi: 10.1002/iid3.965. Immun Inflamm Dis. 2023. PMID: 37647440 Free PMC article.
INTRODUCTION: This study endeavored to investigate the role of DOCK8 in modulating the immune function triggered by sepsis. METHODS: Expression of DOCK8 in the whole blood of sepsis patients and its enrichment pathways were assayed by bioinformatics. ...Bioinformati …
INTRODUCTION: This study endeavored to investigate the role of DOCK8 in modulating the immune function triggered by sepsis. METHODS: …
Wiskott-Aldrich Syndrome (WAS) and Dedicator of Cytokinesis 8- (DOCK8) Deficiency.
Albert MH, Freeman AF. Albert MH, et al. Front Pediatr. 2019 Nov 5;7:451. doi: 10.3389/fped.2019.00451. eCollection 2019. Front Pediatr. 2019. PMID: 31750279 Free PMC article. Review.
Both Wiskott-Aldrich syndrome (WAS) and dedicator of cytokinesis 8 (DOCK8) deficiency are primary immunodeficiency diseases caused by mutations in genes that result in defective organization of the cytoskeleton in hematopoietic tissues. ...In WAS it is sometimes difficult …
Both Wiskott-Aldrich syndrome (WAS) and dedicator of cytokinesis 8 (DOCK8) deficiency are primary immunodeficiency diseases caused by …
dock8 deficiency attenuates microglia colonization in early zebrafish larvae.
Wu L, Xue R, Chen J, Xu J. Wu L, et al. Cell Death Discov. 2022 Aug 17;8(1):366. doi: 10.1038/s41420-022-01155-6. Cell Death Discov. 2022. PMID: 35977943 Free PMC article.
The functions of DOCK8 in microglia development are not fully understood. Here, we generated zebrafish dock8 mutants by CRISPR/Cas9 genome editing and showed that dock8 mutations attenuate microglia colonization in the zebrafish midbrain at early larvae stage …
The functions of DOCK8 in microglia development are not fully understood. Here, we generated zebrafish dock8 mutants by CRISPR …
DOCK8 immune deficiency as a model for primary cytoskeletal dysfunction.
McGhee SA, Chatila TA. McGhee SA, et al. Dis Markers. 2010;29(3-4):151-6. doi: 10.3233/DMA-2010-0740. Dis Markers. 2010. PMID: 21178274 Free PMC article. Review.
Although little is known about the DOCK8 protein, it resembles other atypical guanine exchange factors in the DOCK family, and is known to bind to CDC42. This suggests that a likely role for DOCK8 is in modulating signals that trigger cytoskeletal reorganization. As …
Although little is known about the DOCK8 protein, it resembles other atypical guanine exchange factors in the DOCK family, and is kno …
455 results