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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1988 3
1989 2
1990 1
1991 1
1992 1
1995 1
1998 1
1999 1
2002 1
2004 1
2005 1
2008 1
2009 2
2010 1
2013 1
2014 3
2015 5
2016 3
2017 6
2018 1
2019 4
2020 3
2021 2
2022 2
2023 2
2024 1

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48 results

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Page 1
Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator.
Althaus AL, Ackley MA, Belfort GM, Gee SM, Dai J, Nguyen DP, Kazdoba TM, Modgil A, Davies PA, Moss SJ, Salituro FG, Hoffmann E, Hammond RS, Robichaud AJ, Quirk MC, Doherty JJ. Althaus AL, et al. Among authors: doherty jj. Neuropharmacology. 2020 Dec 15;181:108333. doi: 10.1016/j.neuropharm.2020.108333. Epub 2020 Sep 22. Neuropharmacology. 2020. PMID: 32976892 Free PMC article.
Trial of SAGE-217 in Patients with Major Depressive Disorder.
Gunduz-Bruce H, Silber C, Kaul I, Rothschild AJ, Riesenberg R, Sankoh AJ, Li H, Lasser R, Zorumski CF, Rubinow DR, Paul SM, Jonas J, Doherty JJ, Kanes SJ. Gunduz-Bruce H, et al. Among authors: doherty jj. N Engl J Med. 2019 Sep 5;381(10):903-911. doi: 10.1056/NEJMoa1815981. N Engl J Med. 2019. PMID: 31483961 Clinical Trial.
Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions.
Tang W, Beckley JT, Zhang J, Song R, Xu Y, Kim S, Quirk MC, Robichaud AJ, Diaz ES, Myers SJ, Doherty JJ, Ackley MA, Traynelis SF, Yuan H. Tang W, et al. Among authors: doherty jj. Cell Mol Life Sci. 2023 Jan 16;80(2):42. doi: 10.1007/s00018-022-04667-7. Cell Mol Life Sci. 2023. PMID: 36645496 Free PMC article.
The endosomal apparatus and transmembrane signalling.
Bergeron JJ, Lai WH, Kay DG, Doherty JJ 2nd, Khan MN, Posner BI. Bergeron JJ, et al. Among authors: doherty jj 2nd. Adv Exp Med Biol. 1988;234:213-24. doi: 10.1007/978-1-4757-1980-2_14. Adv Exp Med Biol. 1988. PMID: 3063087 Review. No abstract available.
SAGE-718: A First-in-Class N-Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment.
Hill MD, Blanco MJ, Salituro FG, Bai Z, Beckley JT, Ackley MA, Dai J, Doherty JJ, Harrison BL, Hoffmann EC, Kazdoba TM, Lanzetta D, Lewis M, Quirk MC, Robichaud AJ. Hill MD, et al. Among authors: doherty jj. J Med Chem. 2022 Jul 14;65(13):9063-9075. doi: 10.1021/acs.jmedchem.2c00313. Epub 2022 Jul 2. J Med Chem. 2022. PMID: 35785990
Brexanolone as adjunctive therapy in super-refractory status epilepticus.
Rosenthal ES, Claassen J, Wainwright MS, Husain AM, Vaitkevicius H, Raines S, Hoffmann E, Colquhoun H, Doherty JJ, Kanes SJ. Rosenthal ES, et al. Among authors: doherty jj. Ann Neurol. 2017 Sep;82(3):342-352. doi: 10.1002/ana.25008. Epub 2017 Sep 11. Ann Neurol. 2017. PMID: 28779545 Free PMC article. Clinical Trial.
Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.
Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S. Linsenbardt AJ, et al. Among authors: doherty jj. Neuropharmacology. 2014 Oct;85:232-42. doi: 10.1016/j.neuropharm.2014.05.027. Epub 2014 May 27. Neuropharmacology. 2014. PMID: 24878244 Free PMC article.
Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models.
Hammond RS, Althaus AL, Ackley MA, Maciag C, Martinez Botella G, Salituro FG, Robichaud AJ, Doherty JJ. Hammond RS, et al. Among authors: doherty jj. Epilepsy Res. 2017 Aug;134:16-25. doi: 10.1016/j.eplepsyres.2017.05.001. Epub 2017 May 7. Epilepsy Res. 2017. PMID: 28521115
48 results