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48 results

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Page 1
Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator.
Althaus AL, Ackley MA, Belfort GM, Gee SM, Dai J, Nguyen DP, Kazdoba TM, Modgil A, Davies PA, Moss SJ, Salituro FG, Hoffmann E, Hammond RS, Robichaud AJ, Quirk MC, Doherty JJ. Althaus AL, et al. Among authors: doherty jj. Neuropharmacology. 2020 Dec 15;181:108333. doi: 10.1016/j.neuropharm.2020.108333. Epub 2020 Sep 22. Neuropharmacology. 2020. PMID: 32976892 Free PMC article.
Trial of SAGE-217 in Patients with Major Depressive Disorder.
Gunduz-Bruce H, Silber C, Kaul I, Rothschild AJ, Riesenberg R, Sankoh AJ, Li H, Lasser R, Zorumski CF, Rubinow DR, Paul SM, Jonas J, Doherty JJ, Kanes SJ. Gunduz-Bruce H, et al. Among authors: doherty jj. N Engl J Med. 2019 Sep 5;381(10):903-911. doi: 10.1056/NEJMoa1815981. N Engl J Med. 2019. PMID: 31483961 Clinical Trial.
SAGE-718: A First-in-Class N-Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment.
Hill MD, Blanco MJ, Salituro FG, Bai Z, Beckley JT, Ackley MA, Dai J, Doherty JJ, Harrison BL, Hoffmann EC, Kazdoba TM, Lanzetta D, Lewis M, Quirk MC, Robichaud AJ. Hill MD, et al. Among authors: doherty jj. J Med Chem. 2022 Jul 14;65(13):9063-9075. doi: 10.1021/acs.jmedchem.2c00313. Epub 2022 Jul 2. J Med Chem. 2022. PMID: 35785990
Different oxysterols have opposing actions at N-methyl-D-aspartate receptors.
Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S. Linsenbardt AJ, et al. Among authors: doherty jj. Neuropharmacology. 2014 Oct;85:232-42. doi: 10.1016/j.neuropharm.2014.05.027. Epub 2014 May 27. Neuropharmacology. 2014. PMID: 24878244 Free PMC article.
Maternal preconception PFOS exposure of Drosophila melanogaster alters reproductive capacity, development, morphology and nutrient regulation.
Kim JH, Barbagallo B, Annunziato K, Farias-Pereira R, Doherty JJ, Lee J, Zina J, Tindal C, McVey C, Aresco R, Johnstone M, Sant KE, Timme-Laragy A, Park Y, Clark JM. Kim JH, et al. Among authors: doherty jj. Food Chem Toxicol. 2021 May;151:112153. doi: 10.1016/j.fct.2021.112153. Epub 2021 Mar 25. Food Chem Toxicol. 2021. PMID: 33774094 Free PMC article.
Brexanolone as adjunctive therapy in super-refractory status epilepticus.
Rosenthal ES, Claassen J, Wainwright MS, Husain AM, Vaitkevicius H, Raines S, Hoffmann E, Colquhoun H, Doherty JJ, Kanes SJ. Rosenthal ES, et al. Among authors: doherty jj. Ann Neurol. 2017 Sep;82(3):342-352. doi: 10.1002/ana.25008. Epub 2017 Sep 11. Ann Neurol. 2017. PMID: 28779545 Free PMC article. Clinical Trial.
48 results