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Page 1
Zebrafish dscaml1 Deficiency Impairs Retinal Patterning and Oculomotor Function.
Ma M, Ramirez AD, Wang T, Roberts RL, Harmon KE, Schoppik D, Sharma A, Kuang C, Goei SL, Gagnon JA, Zimmerman S, Tsai SQ, Reyon D, Joung JK, Aksay ERF, Schier AF, Pan YA. Ma M, et al. J Neurosci. 2020 Jan 2;40(1):143-158. doi: 10.1523/JNEUROSCI.1783-19.2019. Epub 2019 Nov 4. J Neurosci. 2020. PMID: 31685652 Free PMC article.
Genetic perturbation of dscaml1 resulted in deficits in retinal patterning and light adaptation, consistent with its known roles in mammals. ...Using the zebrafish model, this study shows that dscaml1 mutants have a host of oculomotor (eye movement) deficits. Notabl …
Genetic perturbation of dscaml1 resulted in deficits in retinal patterning and light adaptation, consistent with its known roles in m …
Potential involvement of DSCAML1 mutations in neurodevelopmental disorders.
Ogata S, Hashizume K, Hayase Y, Kanno Y, Hori K, Balan S, Yoshikawa T, Takahashi H, Taya S, Hoshino M. Ogata S, et al. Genes Cells. 2021 Mar;26(3):136-151. doi: 10.1111/gtc.12831. Epub 2021 Feb 18. Genes Cells. 2021. PMID: 33501714 Free article.
We then performed in silico analyses to estimate the potential damage to the mutated DSCAML1 proteins and chose three representative mutations (DSCAML1(C729R) , DSCAML1(R1685*) and DSCAML1(K2108Nfs*37) ), which lacked a cysteine residue in the seventh …
We then performed in silico analyses to estimate the potential damage to the mutated DSCAML1 proteins and chose three representative …
The rod synapse in aging wildtype and Dscaml1 mutant mice.
Clemons MR, Dimico RH, Black C, Schlussler MK, Camerino MJ, Aldinger-Gibson K, Bartle A, Reynolds N, Eisenbrandt D, Rogers A, Andrianu J, Bruce B, Elliot A, Breazeal T, Griffin H, Murphy MK, Fuerst PG. Clemons MR, et al. PLoS One. 2023 Nov 1;18(11):e0290257. doi: 10.1371/journal.pone.0290257. eCollection 2023. PLoS One. 2023. PMID: 37910517 Free PMC article.
Down Syndrome cell adhesion molecule like 1 (Dscaml1) is expressed by rods, rod bipolar cells (RBCs), and sub-populations of amacrine cells, and has been linked to a middle age onset of CSNB in humans. However, how Dscaml1 contributes to this visual deficit remains …
Down Syndrome cell adhesion molecule like 1 (Dscaml1) is expressed by rods, rod bipolar cells (RBCs), and sub-populations of amacrine …
Roles for DSCAM and DSCAML1 in central nervous system development and disease.
Montesinos ML. Montesinos ML. Adv Neurobiol. 2014;8:249-70. doi: 10.1007/978-1-4614-8090-7_11. Adv Neurobiol. 2014. PMID: 25300140 Review.
In this chapter, we will review the functions ascribed to the two paralogous proteins found in humans, DSCAM and DSCAML1 (DSCAM-like 1), based on findings in knockout mice. The signaling pathways downstream of DSCAM activation and the role of DSCAM miss-expression in disea …
In this chapter, we will review the functions ascribed to the two paralogous proteins found in humans, DSCAM and DSCAML1 (DSCAM-like …
Genetic effects of DSCAML1 identified in genome-wide association study revealing strong associations with litter size and semen quality in goat (Capra hircus).
Wang K, Kang Z, Jiang E, Yan H, Zhu H, Liu J, Qu L, Lan X, Pan C. Wang K, et al. Theriogenology. 2020 Apr 1;146:20-25. doi: 10.1016/j.theriogenology.2020.01.079. Epub 2020 Feb 1. Theriogenology. 2020. PMID: 32036056
The down syndrome cell adhesion molecule like 1 (DSCAML1), is associated with the development of the nervous system and neurologic diseases. ...In male goats, the different genotypes of P2-16bp and P14-15bp revealed a noticeable effect on the expression of DSCAML1. …
The down syndrome cell adhesion molecule like 1 (DSCAML1), is associated with the development of the nervous system and neurologic di …
Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility.
Hayase Y, Amano S, Hashizume K, Tominaga T, Miyamoto H, Kanno Y, Ueno-Inoue Y, Inoue T, Yamada M, Ogata S, Balan S, Hayashi K, Miura Y, Tokudome K, Ohno Y, Nishijo T, Momiyama T, Yanagawa Y, Takizawa A, Mashimo T, Serikawa T, Sekine A, Nakagawa E, Takeshita E, Yoshikawa T, Waga C, Inoue K, Goto YI, Nabeshima Y, Ihara N, Yamakawa K, Taya S, Hoshino M. Hayase Y, et al. Acta Neuropathol Commun. 2020 Nov 30;8(1):206. doi: 10.1186/s40478-020-01082-6. Acta Neuropathol Commun. 2020. PMID: 33256836 Free PMC article.
In this report, via linkage analysis, we identified Down syndrome cell adhesion molecule-like 1(Dscaml1) as the responsible gene for IER. A single base mutation in Dscaml1 causes abnormal splicing, leading to lack of DSCAML1. ...Our findings suggest that muta …
In this report, via linkage analysis, we identified Down syndrome cell adhesion molecule-like 1(Dscaml1) as the responsible gene for …
DSCAM and DSCAML1 regulate the radial migration and callosal projection in developing cerebral cortex.
Zhang L, Huang Y, Chen JY, Ding YQ, Song NN. Zhang L, et al. Brain Res. 2015 Jan 12;1594:61-70. doi: 10.1016/j.brainres.2014.10.060. Epub 2014 Nov 4. Brain Res. 2015. PMID: 25451118
Here we reduced the expression of DSCAM or DSCAML1 in mouse cortical neurons by RNA interference both in vitro and in vivo. We found that knockdown of DSCAM or DSCAML1 increases the complexity of proximal dendritic branching, and impedes the axon growth in cultured …
Here we reduced the expression of DSCAM or DSCAML1 in mouse cortical neurons by RNA interference both in vitro and in vivo. We found …
Deficiency in the cell-adhesion molecule dscaml1 impairs hypothalamic CRH neuron development and perturbs normal neuroendocrine stress axis function.
Ma M, Brunal AA, Clark KC, Studtmann C, Stebbins K, Higashijima SI, Pan YA. Ma M, et al. Front Cell Dev Biol. 2023 Feb 16;11:1113675. doi: 10.3389/fcell.2023.1113675. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 36875755 Free PMC article.
Physiologically, dscaml1 mutant animals had higher baseline stress hormone (cortisol) levels and attenuated responses to acute stressors. Together, these findings identify dscaml1 as an essential factor for stress axis development and suggest that HPA axis dysregula …
Physiologically, dscaml1 mutant animals had higher baseline stress hormone (cortisol) levels and attenuated responses to acute stress …
DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.
Fuerst PG, Bruce F, Tian M, Wei W, Elstrott J, Feller MB, Erskine L, Singer JH, Burgess RW. Fuerst PG, et al. Neuron. 2009 Nov 25;64(4):484-97. doi: 10.1016/j.neuron.2009.09.027. Neuron. 2009. PMID: 19945391 Free PMC article.
RGCs had fasciculated dendrites and clumped cell bodies in Dscam(-/-) mice, suggesting a role in self-avoidance. Dscaml1 was expressed in the rod circuit, and mice lacking Dscaml1 had fasciculated rod bipolar cell dendrites and clumped AII amacrine cell bodies, also …
RGCs had fasciculated dendrites and clumped cell bodies in Dscam(-/-) mice, suggesting a role in self-avoidance. Dscaml1 was expresse …
Tyrosine phosphorylation is essential for DSCAML1 to promote dendrite arborization of mouse cortical neurons.
Cui S, Lao L, Duan J, Jin G, Hou X. Cui S, et al. Neurosci Lett. 2013 Oct 25;555:193-7. doi: 10.1016/j.neulet.2013.09.052. Epub 2013 Sep 29. Neurosci Lett. 2013. PMID: 24084194
Introduction of a DSCAML1(Y1808F) mutant into the DSCAML1-knocked down neurons failed to reverse the abnormal dendritic arborization. These results suggest that DSCAML1 promotes dendritic self-avoidance in cortical neurons, and that phosphorylation at Y1808 i …
Introduction of a DSCAML1(Y1808F) mutant into the DSCAML1-knocked down neurons failed to reverse the abnormal dendritic arbori …
40 results