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Knockout of the longevity gene Klotho perturbs aging- and Alzheimer's disease-linked brain microRNAs and tRNA fragments.
Dubnov S, Yayon N, Yakov O, Bennett DA, Seshadri S, Mufson E, Tzur Y, Bennet ER, Greenberg D, Kuro-O M, Paldor I, Abraham CR, Soreq H. Dubnov S, et al. bioRxiv [Preprint]. 2023 Sep 12:2023.09.10.557032. doi: 10.1101/2023.09.10.557032. bioRxiv. 2023. Update in: Commun Biol. 2024 Jun 11;7(1):720. doi: 10.1038/s42003-024-06407-y. PMID: 37745362 Free PMC article. Updated. Preprint.
High-throughput morphometric and transcriptomic profiling uncovers composition of naïve and sensory-deprived cortical cholinergic VIP/CHAT neurons.
Yayon N, Amsalem O, Zorbaz T, Yakov O, Dubnov S, Winek K, Dudai A, Adam G, Schmidtner AK, Tessier-Lavigne M, Renier N, Habib N, Segev I, London M, Soreq H. Yayon N, et al. Among authors: dubnov s. EMBO J. 2023 Jan 4;42(1):e110565. doi: 10.15252/embj.2021110565. Epub 2022 Nov 15. EMBO J. 2023. PMID: 36377476 Free PMC article.
Sex-specific declines in cholinergic-targeting tRNA fragments in the nucleus accumbens in Alzheimer's disease.
Shulman D, Dubnov S, Zorbaz T, Madrer N, Paldor I, Bennett DA, Seshadri S, Mufson EJ, Greenberg DS, Loewenstein Y, Soreq H. Shulman D, et al. Among authors: dubnov s. bioRxiv [Preprint]. 2023 Feb 20:2023.02.08.527612. doi: 10.1101/2023.02.08.527612. bioRxiv. 2023. Update in: Alzheimers Dement. 2023 Nov;19(11):5159-5172. doi: 10.1002/alz.13095. PMID: 36798311 Free PMC article. Updated. Preprint.
Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade.
Winek K, Lobentanzer S, Nadorp B, Dubnov S, Dames C, Jagdmann S, Moshitzky G, Hotter B, Meisel C, Greenberg DS, Shifman S, Klein J, Shenhar-Tsarfaty S, Meisel A, Soreq H. Winek K, et al. Among authors: dubnov s. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32606-32616. doi: 10.1073/pnas.2013542117. Epub 2020 Dec 7. Proc Natl Acad Sci U S A. 2020. PMID: 33288717 Free PMC article.