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Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2.
Yaseen S, Demopulos G, Dudler T, Yabuki M, Wood CL, Cummings WJ, Tjoelker LW, Fujita T, Sacks S, Garred P, Andrew P, Sim RB, Lachmann PJ, Wallis R, Lynch N, Schwaeble WJ. Yaseen S, et al. Among authors: dudler t. FASEB J. 2017 May;31(5):2210-2219. doi: 10.1096/fj.201601306R. Epub 2017 Feb 10. FASEB J. 2017. PMID: 28188176
Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury.
Mercurio D, Pischiutta F, Seminara S, Tribuzio F, Lisi I, Pasetto L, Bonetto V, De Simoni MG, Schwaeble W, Yaseen S, Dudler T, Zanier ER, Fumagalli S. Mercurio D, et al. Among authors: dudler t. J Neuroinflammation. 2024 May 28;21(1):141. doi: 10.1186/s12974-024-03133-4. J Neuroinflammation. 2024. PMID: 38807149 Free PMC article.
Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins.
Ali YM, Ferrari M, Lynch NJ, Yaseen S, Dudler T, Gragerov S, Demopulos G, Heeney JL, Schwaeble WJ. Ali YM, et al. Among authors: dudler t. Front Immunol. 2021 Jul 5;12:714511. doi: 10.3389/fimmu.2021.714511. eCollection 2021. Front Immunol. 2021. PMID: 34290717 Free PMC article.
28 results