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Expression of phosphodiesterase 4D (PDE4D) is regulated by both the cyclic AMP-dependent protein kinase and mitogen-activated protein kinase signaling pathways. A potential mechanism allowing for the coordinated regulation of PDE4D activity and expression in cells.
Liu H, Palmer D, Jimmo SL, Tilley DG, Dunkerley HA, Pang SC, Maurice DH. Liu H, et al. Among authors: dunkerley ha. J Biol Chem. 2000 Aug 25;275(34):26615-24. doi: 10.1074/jbc.M001634200. J Biol Chem. 2000. PMID: 10851231 Free article.
Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease.
Netherton SJ, Jimmo SL, Palmer D, Tilley DG, Dunkerley HA, Raymond DR, Russell JC, Absher PM, Sage EH, Vernon RB, Maurice DH. Netherton SJ, et al. Among authors: dunkerley ha. Diabetes. 2002 Apr;51(4):1194-200. doi: 10.2337/diabetes.51.4.1194. Diabetes. 2002. PMID: 11916944