Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
2000 1
2002 2
2003 1
2004 1
2005 2
2007 2
2008 3
2009 1
2010 4
2011 6
2012 9
2013 9
2014 4
2015 4
2016 2
2017 4
2018 7
2019 8
2020 8
2021 8
2022 3
2023 4
2024 4
2025 12
2026 3

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

102 results

Results by year

Filters applied: . Clear all
Page 1
Caffeine ameliorates metabolic-associated steatohepatitis by rescuing hepatic Dusp9.
Xin X, Chen C, Xu X, Lv S, Sun Q, An Z, Chen Y, Xiong Z, Hu Y, Feng Q. Xin X, et al. Redox Biol. 2025 Mar;80:103499. doi: 10.1016/j.redox.2025.103499. Epub 2025 Jan 22. Redox Biol. 2025. PMID: 39879738 Free PMC article.
Dusp9 knockdown in vivo and in vitro exacerbated glycolipid metabolism disorders and stunningly counteracted the systemic therapeutic effects of CAFF in the MASH models. In addition, CAFF inactivated the ASK1-p38/JNK, a downstream signaling pathway of Dusp9, which r …
Dusp9 knockdown in vivo and in vitro exacerbated glycolipid metabolism disorders and stunningly counteracted the systemic therapeutic …
DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell Biology and Human Diseases.
Khoubai FZ, Grosset CF. Khoubai FZ, et al. Int J Mol Sci. 2021 Oct 26;22(21):11538. doi: 10.3390/ijms222111538. Int J Mol Sci. 2021. PMID: 34768967 Free PMC article. Review.
As a consequence, DUSP9 plays a major role in human pathologies and more specifically in cardiac dysfunction, liver metabolic syndromes, diabetes, obesity and cancer including drug response and cell stemness. Here, we recapitulate the mechanism of action of DUSP9 in …
As a consequence, DUSP9 plays a major role in human pathologies and more specifically in cardiac dysfunction, liver metabolic syndrom …
DUSP9-mediated inhibition of IRS1/PI3K/AKT pathway contributes to insulin resistance and metabolic dysfunction in gestational diabetes mellitus.
Zhang X, Jin Y. Zhang X, et al. Hum Immunol. 2025 May;86(3):111263. doi: 10.1016/j.humimm.2025.111263. Epub 2025 Feb 27. Hum Immunol. 2025. PMID: 40020430

Moreover, DUSP9 knockdown in these mice promoted activation of the IRS1/PI3K/AKT signaling pathway (p < 0.01). ...The knockdown of DUSP9 ameliorates key pathological features of GDM, including insulin resistance, impaired lipid metabolism, and placental apoptosis

…

Moreover, DUSP9 knockdown in these mice promoted activation of the IRS1/PI3K/AKT signaling pathway (p < 0.01). ...The knockdown of

…
DUSP9 alleviates hepatic ischemia/reperfusion injury by restraining both mitogen-activated protein kinase and IKK in an apoptosis signal-regulating kinase 1-dependent manner.
Li Z, Huang Z, Luo Y, Yang H, Yang M. Li Z, et al. Acta Biochim Biophys Sin (Shanghai). 2022 Dec 25;54(12):1811-1821. doi: 10.3724/abbs.2022183. Acta Biochim Biophys Sin (Shanghai). 2022. PMID: 36789693 Free PMC article.
In the present study, we find that DUSP9 is reduced in mouse hepatic I/R injury. DUSP9 enrichment attenuates hepatic inflammation both in vivo and in vitro as revealed by western blot analysis and qRT-PCR. ...The present study documents a novel role of DUSP9 …
In the present study, we find that DUSP9 is reduced in mouse hepatic I/R injury. DUSP9 enrichment attenuates hepatic inflammat …
DUSP9 Suppresses Proliferation and Migration of Clear Cell Renal Cell Carcinoma via the mTOR Pathway.
Luo J, Luo X, Liu X, Fang Z, Xu J, Li L. Luo J, et al. Onco Targets Ther. 2020 Feb 13;13:1321-1330. doi: 10.2147/OTT.S239407. eCollection 2020. Onco Targets Ther. 2020. PMID: 32103999 Free PMC article.
In addition, nude mouse xenograft experiment establishes an in vivo model to detect the inhibitory effect of DUSP9 on tumor proliferation. RESULTS: DUSP9 was significantly down-regulated in both ccRCC cell lines and ccRCC tissues compared to that in non-cancer cell …
In addition, nude mouse xenograft experiment establishes an in vivo model to detect the inhibitory effect of DUSP9 on tumor prolifera …
m(6)A-mediated HDAC9 upregulation promotes particulate matter-induced airway inflammation via epigenetic control of DUSP9-MAPK axis and acts as an inhaled nanotherapeutic target.
Zeng Y, Bai X, Zhu G, Zhu M, Peng W, Song J, Cai H, Ye L, Chen C, Song Y, Jin M, Zhang XQ, Wang J. Zeng Y, et al. J Hazard Mater. 2024 Sep 15;477:135093. doi: 10.1016/j.jhazmat.2024.135093. Epub 2024 Jul 6. J Hazard Mater. 2024. PMID: 39088948
Mechanistically, HDAC9 modulated the deacetylation of histone 4 acetylation at K12 (H4K12) in the promoter region of dual specificity phosphatase 9 (DUSP9) to repress the expression of DUSP9 and resulting in the activation of MAPK signaling pathway, thereby promotin …
Mechanistically, HDAC9 modulated the deacetylation of histone 4 acetylation at K12 (H4K12) in the promoter region of dual specificity phosph …
DUSP9-mediated reduction of pERK1/2 supports cancer stem cell-like traits and promotes triple negative breast cancer.
Jimenez T, Barrios A, Tucker A, Collazo J, Arias N, Fazel S, Baker M, Halim M, Huynh T, Singh R, Pervin S. Jimenez T, et al. Am J Cancer Res. 2020 Oct 1;10(10):3487-3506. eCollection 2020. Am J Cancer Res. 2020. PMID: 33163285 Free PMC article.
Family members of DUSPs examined, showed increase in DUSP9 expression in TN xenografts. Increased DUSP9 expression in xenografts was consistently associated with upregulation of SC-specific proteins, ALDH1 and SOX2/OCT4. ...Therefore, targeting DUSP9 could be …
Family members of DUSPs examined, showed increase in DUSP9 expression in TN xenografts. Increased DUSP9 expression in xenograf …
DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells.
Choi J, Clement K, Huebner AJ, Webster J, Rose CM, Brumbaugh J, Walsh RM, Lee S, Savol A, Etchegaray JP, Gu H, Boyle P, Elling U, Mostoslavsky R, Sadreyev R, Park PJ, Gygi SP, Meissner A, Hochedlinger K. Choi J, et al. Cell Stem Cell. 2017 May 4;20(5):706-719.e7. doi: 10.1016/j.stem.2017.03.002. Epub 2017 Mar 30. Cell Stem Cell. 2017. PMID: 28366588 Free PMC article.
We show that the X-linked MAPK phosphatase DUSP9 is upregulated in female compared to male ESCs, and its heterozygous loss in female ESCs leads to male-like methylation levels. ...Collectively, our data demonstrate the epigenetic similarity of sex-matched ESCs and EGCs and …
We show that the X-linked MAPK phosphatase DUSP9 is upregulated in female compared to male ESCs, and its heterozygous loss in female …
miR-132-3p Modulates DUSP9-Dependent p38/JNK Signaling Pathways to Enhance Inflammation in the Amnion Leading to Labor.
Zhong Z, Liu Z, Zheng R, Chai J, Jiang S. Zhong Z, et al. Int J Mol Sci. 2022 Feb 7;23(3):1864. doi: 10.3390/ijms23031864. Int J Mol Sci. 2022. PMID: 35163786 Free PMC article.
DUSP9 was present in the mouse amnion epithelial cells, with a decrease in its abundance at 18.5 days post coitum (dpc) relative to 15.5 dpc. ...Additionally, intraperitoneal injection of pregnant mice with miR-132-3p agomir not only caused preterm birth, but also promoted …
DUSP9 was present in the mouse amnion epithelial cells, with a decrease in its abundance at 18.5 days post coitum (dpc) relative to 1 …
DUSP9 is Up-Regulated and Promotes Tumor Progression in Head and Neck Squamous Cell Carcinoma.
Hu Y, Li Y, Jiang C, Han W, Chen X, Wang P, Xu H. Hu Y, et al. J Cancer. 2025 Jul 24;16(11):3403-3414. doi: 10.7150/jca.110597. eCollection 2025. J Cancer. 2025. PMID: 40861803 Free PMC article.
Survival analysis revealed that high levels of DUSP9 expression contribute to poor prognosis in HNSCC patients. Knockdown of DUSP9 decreased, but overexpression of DUSP9 increased the proliferation and migration of HNSCC cells. ...Enrichment analyses of DU …
Survival analysis revealed that high levels of DUSP9 expression contribute to poor prognosis in HNSCC patients. Knockdown of DUSP9 …
102 results